Borneol-Shellac Nanofiber Membranes Fabricated Using a Modified Coaxial Electrospinning

Yu, Deng Guang; Xu, Ying; Liu, Song; Wang, Yu Hai; Duan, Xiao Feng; Wang, Xia

doi:10.4028/www.scientific.net/amr.1058.78

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…At the same time, the shellac nanofibers transformed into nanoparticles and finally dissolved completely . Interestingly, Yu et al . prepared borneol-loaded shellac nanofibers through coaxial electrospinning using pure ethanol as the sheath fluid and a borneol-shellac ethanol solution as the core fluid.…”

Section: Shellac-based Delivery Systemsmentioning

confidence: 99%

“…At the same time, the shellac nanofibers transformed into nanoparticles and finally dissolved completely. 14 Interestingly, Yu et al 214 prepared borneolloaded shellac nanofibers through coaxial electrospinning using pure ethanol as the sheath fluid and a borneol-shellac ethanol solution as the core fluid. Borneol exists in an amorphous state in the shellac matrix, which improves its physical stability owing to the hydrogen bonding between borneol and shellac.…”

Section: Shellac-based Delivery Systemsmentioning

confidence: 99%

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Multiscale Shellac-Based Delivery Systems: From Macro- to Nanoscale

Yuan

Dong

et al. 2021

ACS Nano

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Delivery systems play a crucial role in enhancing the activity of active substances; however, they require complex processing techniques and raw material design to achieve the desired properties. In this regard, raw materials that can be easily processed for different delivery systems are garnering attention. Among these raw materials, shellac, which is the only pharmaceutically used resin of animal origin, has been widely used in the development of various delivery systems owing to its pH responsiveness, biocompatibility, and degradability. Notably, shellac performs better on encapsulating hydrophobic active substances than other natural polymers, such as polysaccharides and proteins. In addition, specially designed shellac-based delivery systems can also be used for the codelivery of hydrophilic and hydrophobic active substances. Shellac is most widely used for oral administration, as shellac-based delivery systems can form a compact structure through hydrophobic interaction, protecting transported active substances from the harsh environment of the stomach to achieve targeted delivery in the small intestine or colon. In this review, the advantages of shellac in delivery systems are discussed in detail. Multiscale shellac-based delivery systems from the macroscale to nanoscale are comprehensively introduced, including matrix tablets, films, enteric coatings, hydrogels, microcapsules, microparticles (beads/spheres), nanoparticles, and nanofibers. Furthermore, the hotspots, deficiencies, and future perspectives of shellac-based delivery system development are also analyzed. We hoped this review will increase the understanding of shellac-based delivery systems and inspire their further development.

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Section: Shellac-based Delivery Systemsmentioning

confidence: 99%

Section: Shellac-based Delivery Systemsmentioning

confidence: 99%

Multiscale Shellac-Based Delivery Systems: From Macro- to Nanoscale

Yuan

Dong

et al. 2021

ACS Nano

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“…Borneol and polyvinylpyrrolidone (PVP) and shellac nanocomposites were electrospun to enhance drug dissolution rates and improve drug physical stability. 9,10 There are carbanyl groups along the CAB main chain that can bond with borneol to decrease its sublimation. Therefore, in this paper, PLLA/CAB composite nano-fibrous composite membranes were developed as borneol carriers.…”

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confidence: 99%

Controlled release of borneol from nano-fibrous poly(L-lactic acid)/ cellulose acetate butyrate membrane

Luo

Leung

et al. 2015

Textile Research Journal

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Borneol, one of the commonly used Chinese medicines, can be used to treat many diseases. The main ingredient of natural borneol is d-borneol extracted from the volatile oil of dipterocarp trees. Numerous studies have proved the effectiveness of borneol. It has been widely used in relieving symptoms of anxiety, fatigue and insomnia; inducing anaesthesia and analgesia to alleviate abdominal pain, wounds and burns; relieving rheumatic pain, hemorrhoids, skin diseases and ulcerations of the mouth, ears, eyes or nose; treating sore throats and skin infections; and is mainly used to treat cardiovascular and cerebrovascular diseases. Although borneol has a significant therapeutic effect, its easy sublimation and low water absorbability make it difficult to control the efficiency of delivery and decrease its function in connecting to various applications in the needs of modern society. Electrospun nanofiber has been commonly used as a delivery vehicle for various medicines for biomedical applications. Poly(L-lactic acid) and cellulose acetate butyrate (CAB) nano-fibrous nonwoven membranes were electrospun and used as drug carriers for borneol. To load borneol into a PLLA/CAB composite membrane, borneol/acetone solution was sprayed on PLLA/CAB fibers. While part of the CAB was dissolved by acetone, borneol was combined with CAB by hydrogen bonds between hydroxyl and carbanyl groups. PLLA still kept a porous morphology of the whole drug-loaded membrane since it does dissolve in acetone. This structure provided a high quality and stable drug delivery system. With adjustable drug release properties, PLLA/CAB nano-fibrous composite nonwoven membranes can be alternative candidates for developing novel external medical textiles.Keywords borneol, drug release, electrospinning, poly(L-lactic acid), cellulose acetate butyrate Borneol, a monoterpenoid alcohol, is the main component derived from Dryobalanops aromatica (a species of plant belonging to the teak family). The main ingredient of natural borneol is d-borneol, which is extracted from the volatile oil of dipterocarp trees. Numerous studies have proved the effectiveness of borneol. 1 It has been widely used in relieving symptoms of anxiety, fatigue and insomnia; inducing anesthesia and analgesia to alleviate abdominal pain, wounds and burns; relieving rheumatic pain, hemorrhoids, skin diseases and ulcerations of the mouth, ears, eyes or nose;, to treat sore throats and skin infections, and is mainly used to treat cardiovascular and cerebrovascular diseases. It can promote drugs' percutaneous absorption, and affects drug pharmacokinetics. Studies also show that borneol can improve the biocompatibility of drugs, improve drug absorption, accelerate the opening of the blood-brain barrier, maintain a steady drug concentration, extend the effect in plasma, and enhance the distribution of drugs in brain tissue. Borneol has a significant therapeutic effect on sciatica and postherpetic neuralgia: both the area of pain and the degree of

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Borneol-Shellac Nanofiber Membranes Fabricated Using a Modified Coaxial Electrospinning

Cited by 2 publications

References 8 publications

Multiscale Shellac-Based Delivery Systems: From Macro- to Nanoscale

Multiscale Shellac-Based Delivery Systems: From Macro- to Nanoscale

Controlled release of borneol from nano-fibrous poly(L-lactic acid)/ cellulose acetate butyrate membrane

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