1999
DOI: 10.1242/jeb.202.12.1649
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Boron is required for zebrafish embryogenesis

Abstract: Boron is the only element known to be essential for plants, but only circumstantial evidence for essentiality exists in animals. We report here that boron is essential for the embryonic development of zebrafish (Danio rerio). Zebrafish were maintained in water with a boron concentration of 0.1 micromol l-1 or supplemented to a concentration of 45 micromol l-1 using ultrapure boric acid. Both groups were fed boron-depleted brine shrimp. This procedure depleted the boron content of the blastulas from low-boron p… Show more

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Cited by 129 publications
(11 citation statements)
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“…In higher plants, boron is essential as a component of the cell wall matrix, and its deficiency affects the growth and expansion of plant organs (Blevins & Lukaszewski, 1998 ; Tanaka & Fujiwara, 2008 ). Boron deficiency impairs embryogenesis in aquatic vertebrate animals such as Xenopus laevis (Fort et al, 2002 ) and zebrafish (Rowe & Eckhert, 1999 ). In mammals, boron provides many beneficial health effects and is considered nutritionally important (Nielsen, 2014 ; Uluisik et al, 2018 ).…”
Section: Introductionmentioning
confidence: 99%
“…In higher plants, boron is essential as a component of the cell wall matrix, and its deficiency affects the growth and expansion of plant organs (Blevins & Lukaszewski, 1998 ; Tanaka & Fujiwara, 2008 ). Boron deficiency impairs embryogenesis in aquatic vertebrate animals such as Xenopus laevis (Fort et al, 2002 ) and zebrafish (Rowe & Eckhert, 1999 ). In mammals, boron provides many beneficial health effects and is considered nutritionally important (Nielsen, 2014 ; Uluisik et al, 2018 ).…”
Section: Introductionmentioning
confidence: 99%
“…At this developmental stage, cell death is not observed, but it appears an abnormal cell division resembling tumour behaviour [ 109 ], indicating an early failure of development and suggesting that B deficiency is not necessarily associated with cell death. Furthermore, low-B results in abnormal embryonic development in animals [ 19 ], also leading to a tumour-like amorphous structure when B deprivation occurs at the early cleavage stage [ 22 ]. Interestingly, boric acid can inhibit cell proliferation in different cancer cell lines [ 146 , 147 ].…”
Section: One Hundred Years Of Boron Researchmentioning
confidence: 99%
“…Even more, its essentiality for plant growth has been questioned with the exciting hypothesis that B is certainly toxic for plants, and plants increase tolerance via phenolic sequestering [ 17 ]. However, the fact that organisms that do not synthesize phenolics, including animals, also suffer malformations under B-starvation [ 18 , 19 , 20 , 21 ], in many cases shared with those occurring in plants [ 22 ], still supports its role as an essential element.…”
Section: Introductionmentioning
confidence: 99%
“…B has not been classified as an essential micronutrient for humans and animals because its biological role has not been clearly identified [ 13 , 14 , 15 ]. However, B has beneficial effects on the biological functions of humans and animals, such as reproduction, growth, calcium metabolism, bone formation, energy metabolism, immunity, brain function, and steroid hormones, including vitamin D and estrogen [ 12 , 16 , 17 , 18 ].…”
Section: Introductionmentioning
confidence: 99%