Boron nitride nanosheets functionalized channel scaffold favors microenvironment rebalance cocktail therapy for piezocatalytic neuronal repair

Qian, Yun; Xu, Yang; Yan, Zhiwen; Jin, Y.; Chen, Xuan; Yuan, Weien; Fan, Cunyi

doi:10.1016/j.nanoen.2021.105779

Cited by 72 publications

(44 citation statements)

References 54 publications

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“…Which also facilitated the recruitment of chemokine receptors (e.g., CXCR4 and CXCR2) from surrounding tissue through the NP‐NGC, and thus improved the migration of microvascular endothelial cells into the defect nerves. [ 56–58 ] The improved neovascularization can provide enough nutritional supply for neural functional reconstruction.…”

Section: Resultsmentioning

confidence: 99%

Physiologically Self‐Regulated, Fully Implantable, Battery‐Free System for Peripheral Nerve Restoration

Jin

Yuan

et al. 2021

Advanced Materials

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The long‐segment peripheral nerve injury (PNI) represents a global medical challenge, leading to incomplete nerve tissue recovery and unsatisfactory functional reconstruction. However, the current electrical stimulation (ES) apparatuses fail perfect nerve repair due to their inability of the variable synchronous self‐regulated function with physiological states. It is urgent to develop an implantable ES platform with physiologically adaptive function to provide instantaneous and nerve‐preferred ES. Here, a physiologically self‐regulated electrical signal is generated by integrating a novel tribo/piezoelectric hybrid nanogenerator with a nanoporous nerve guide conduit to construct a fully implantable neural electrical stimulation (FI‐NES) system. The optimal neural ES parameters completely originate from the body itself and are highly self‐responsive to different physiological states. The morphological evaluation, representative protein expression level, and functional reconstruction of the regenerated nerves are conducted to assess the PNI recovery process. Evidence shows that the recovery effect of 15 mm length nerve defects under the guidance of the FI‐NES system is significantly close to the autograft. The designed FI‐NES system provides an effective method for long‐term accelerating the recovery of PNI in vivo and is also appropriate for other tissue injury or neurodegenerative diseases.

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Section: Resultsmentioning

confidence: 99%

Physiologically Self‐Regulated, Fully Implantable, Battery‐Free System for Peripheral Nerve Restoration

Jin

Yuan

et al. 2021

Advanced Materials

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“…Peripheral nerve regeneration relies on the recovery of neural structure and remodeling of imbalanced neuronal microenvironment ( Jiang et al, 2020 ; Qian et al, 2021a , c ; Yao et al, 2021a ). The inhibition of excessive immune responses is of vital importance to restoring the balance in microenvironment after PNIs ( Qian et al, 2019b , 2020a , b ).…”

Section: Discussionmentioning

confidence: 99%

Tacrolimus-Induced Neurotrophic Differentiation of Adipose-Derived Stem Cells as Novel Therapeutic Method for Peripheral Nerve Injury

Yao

Yan²,

Li³

et al. 2021

Front. Cell. Neurosci.

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Peripheral nerve injuries (PNIs) are frequent traumatic injuries across the globe. Severe PNIs result in irreversible loss of axons and myelin sheaths and disability of motor and sensory function. Schwann cells can secrete neurotrophic factors and myelinate the injured axons to repair PNIs. However, Schwann cells are hard to harvest and expand in vitro, which limit their clinical use. Adipose-derived stem cells (ADSCs) are easily accessible and have the potential to acquire neurotrophic phenotype under the induction of an established protocol. It has been noticed that Tacrolimus/FK506 promotes peripheral nerve regeneration, despite the mechanism of its pro-neurogenic capacity remains undefined. Herein, we investigated the neurotrophic capacity of ADSCs under the stimulation of tacrolimus. ADSCs were cultured in the induction medium for 18 days to differentiate along the glial lineage and were subjected to FK506 stimulation for the last 3 days. We discovered that FK506 greatly enhanced the neurotrophic phenotype of ADSCs which potentiated the nerve regeneration in a crush injury model. This work explored the novel application of FK506 synergized with ADSCs and thus shed promising light on the treatment of severe PNIs.

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“…Given that laser technologies and nanomaterials are being increasingly applied in a variety of medicinal contexts, we believe that this novel strategy to modulate the neural activities is an ideal approach that could be further modified to treat brain diseases and repair nerve injuries. [31][32][33][34][35][36][37] Nevertheless, ongoing efforts are still needed before this technique can be widely adopted by the neuroscience community. For example, the selectivity of this approach could be further improved via nanomaterials' modifications, which has been recently reported to enable high-avidity binding between neurons and nanomaterials; [16] in vivo neural inhibition using photothermal nanomaterials attracts lots of attention, and is yet to be demonstrated while several reports had tested the nanomaterial-based neural inhibition in cultured cells and characterized by patch clamping and MEAs' recording; [38,39] BP-PEG-NSs could also be functionalized to increase the blood-brain barrier permeability for high-efficiency intravenous injection and thus avoid the stereotactic operation and craniotomy; [40][41][42] compatibility with brain imaging techniques, e.g., magnetic resonance imaging, is also an essential issue to be addressed before specific envisioned applications in human healthcare.…”

Section: Discussionmentioning

confidence: 99%

Injectable Black Phosphorus Nanosheets for Wireless Nongenetic Neural Stimulation

Tang

Yang

Liu

et al. 2021

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Neurons can be modified to express light‐sensitive proteins for enabling stimulation with a high spatial and temporal resolution, but such techniques require gene transfection and systematical implantation. Here, a black phosphorus nanosheet‐based injectable strategy is described for wireless neural stimulation both in vitro and in vivo without cell modifications. These nanosheets, with minimal invasiveness, high biocompatibility, and biodegradability, are anchored on cell membranes as miniature near‐infrared (NIR) light transducers to create local heating for neural activity excitation. Based on cultured multielectrode‐array recording, in vivo electrophysiology analysis, and open field behavioral tests, it is demonstrated that remotely applied NIR illumination can reliably trigger spiking activity in cultured neurons and rat brains. Excitingly, reliable regulation of brain function to control animal behaviors is also described. Moreover, this approach has shown its potential for future clinical use by successful high‐frequency stimulation in cells and animals in this proof‐of‐concept study. It is believed that this new method will offer a powerful alternative to other neural stimulation solutions and potentially be of independent value to the healthcare system.

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Boron nitride nanosheets functionalized channel scaffold favors microenvironment rebalance cocktail therapy for piezocatalytic neuronal repair

Cited by 72 publications

References 54 publications

Physiologically Self‐Regulated, Fully Implantable, Battery‐Free System for Peripheral Nerve Restoration

Physiologically Self‐Regulated, Fully Implantable, Battery‐Free System for Peripheral Nerve Restoration

Tacrolimus-Induced Neurotrophic Differentiation of Adipose-Derived Stem Cells as Novel Therapeutic Method for Peripheral Nerve Injury

Injectable Black Phosphorus Nanosheets for Wireless Nongenetic Neural Stimulation

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