Boronate affinity Metal–Organic frameworks for highly efficient cis-diol molecules in-situ enrichment and surface-assisted laser desorption/ionization mass spectrometric detection

Nanostructured Substrates as Matrices for Surface Assisted Laser Desorption/Ionization Mass Spectrometry: A Progress Report from Material Research to Biomedical Applications

“…Among these MOF matrices, MIL-100(Fe) performed the best due to the coordinatively unsaturated metal sites Fe II /Fe III , which could form a more stable complex with the tested polycyclic aromatic hydrocarbon (PAH) molecules through Lewis acid-base interaction and π back donation. Besides pristine 2D MOF nanosheets [81,82] or 3D MOFs, [83][84][85] well-designed MOF through prefunctionalization approach [86] and functional MOFs through post-synthetic modification (PSM) strategy [87][88][89] were also developed as novel matrices in SALDI-MS analysis. Zou et al designed and synthesized new MOFs through post-synthetic exchange and solvothermal approach by choosing 2,5-pyridinedicarboxylic acid and 2,5-dihydroxyterephthalic acid as organic ligands.…”

“…Similar strategy was also used to prepare boronate affinity MOFs for cis-diol molecule analysis. [89] MOF substrates usually have high ionization efficiency, salt tolerance, and good reproducibility. The unique porosity endows them with inherent enrichment ability for a range of analytes such as PAHs, saccharides, peptides with simultaneous size-exclusion of large molecules.…”

Nanocomposite‐Based Matrices in Laser Desorption/Ionization Mass Spectrometry for Small‐Molecule Analysis

“…Besides metal oxides, noble metals are also utilized to form the MOF based composites. Bie et al [54] synthesized a boronate affinity MIL-101@AuNP nanocomposite as the sorbent and LDI matrix for selective enrichment and detection of small cis-diol molecules in human serum, urine, and tea drinks, due to their excellent selectivity, tolerance to interference, and fast binding equilibria. Covalent organic frameworks (COFs), an emerging matrix material, possess high thermal stability, permanent porosity, adjustable pore sizes, high surface areas, and charge-carrier transfer.…”

Emerging Extraction Strategies in Analytical Chemistry

“…In this work, the MOFs were used for dispersive solid-phase extraction of drugs, phenols, polycyclic aromatic hydrocarbons, and personal care products from environmental waters. In another example related to selectivity, the cis-diol compounds adrenaline, riboflavin, and dopamine were extracted from urine based on a boronate affinity MOF, and this was combined with surface-assisted laser desorption/ionization mass spectrometric detection . The selectivity of the MOF relied on the reversible covalent reaction between boronic acid ligands and the cis-diol-containing analytes.…”