Borophene-based biomedical applications: Status and future challenges

Duo, Yanhong; Xie, Zhongjian; Wang, Lude; Abbasi, Nasir M.; Yang, Tingqiang; Li, Zihuang; Hu, Guoxin; Zhang, Han

doi:10.1016/j.ccr.2020.213549

Cited by 65 publications

(38 citation statements)

References 94 publications

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“…Unfortunately, the optical transparent of borophenes offers a relatively low absorption with an extinction coefficient of ≈2.5 L g −1 cm −1 , which is considered as a potential limitation for further development of a pristine borophene as PTT agent. [91] Nevertheless, various possibilities of borophenes' surface modification with drug molecules, for instance doxorubicin, [90,91] offer great possibilities in designing new anticancer modalities. In this regard, the application of MBenes can enable new synergistic effects and further utilization of boron-based compounds in theranostic applications, involving imaging-guided radio-, magneto-, chemo-therapy systems combined with immunotherapy and gene delivery.…”

Section: Potential Impact Of Mbenes In Modern Biotechnologymentioning

confidence: 99%

“…[ 89 ] The unique biological properties and potential biocompatibility of borophenes have been thoroughly investigated in recent years. [ 90 ] It is accepted that the presence of boron enables the development of novel anticancer nanomedicines with multimodal imaging‐guided drug delivery features. Recently, PEGylated 2D borophene showed a lack of cytotoxicity in both in‐vitro and in‐vivo cancer models together with a PTT performance.…”

Section: Potential Impact Of Mbenes In Modern Biotechnologymentioning

confidence: 99%

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Novel 2D MBenes—Synthesis, Structure, and Biotechnological Potential

Jakubczak

Szuplewska

Rozmysłowska-Wojciechowska

et al. 2021

Adv Funct Materials

102

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2D transition metal borides (MBenes) have emerged as promising post-MXene materials with potential application in various biotechnological fields. Although they possess prospective bioactive properties due to boron in their structure, the experience gained from MXenes shows that an in-depth understanding of their biological recognition and response as well as the exploration of their biological applications are highly challenging. This makes the identification of the most promising 2D MBenes for future biological research and final industrial applications rather complicated. Herein, MBenes are differentiated from MXenes and further untangled for their bioactivity-generating features. It is expected that MBenes' positive or negative biological impact on living organisms and different types of cells connect with their morphological, structural and physicochemical features in the context of relevant environments. Necessary toxicological data are also highlighted, which are key aspects to enable MBenes' safe application in biotechnology and nanomedicine. Furthermore, a perspective for the rational development and design of novel biotechnological solutions based on MBenes is provided, which will meet the legal safety requirements for nanomaterials. In this regard, this work is an unprecedented contribution toward strategies for regulatory development for MBene/MXene-type nanomaterials. It provides an inspiration for future biotechnological and nanotoxicological approaches using MBenes.

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Section: Potential Impact Of Mbenes In Modern Biotechnologymentioning

confidence: 99%

Section: Potential Impact Of Mbenes In Modern Biotechnologymentioning

confidence: 99%

Novel 2D MBenes—Synthesis, Structure, and Biotechnological Potential

Jakubczak

Szuplewska

Rozmysłowska-Wojciechowska

et al. 2021

Adv Funct Materials

102

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“…Threats: Other types of materials with good luminescent properties are being developed in parallel and/or in competition with AIE polymers, such as quantum dots, graphene, borophene, phosphorene, transition metal dichalcogenides, perovskites, rare-earth-doped luminescent materials, among others (see references [ 142 , 143 ] and references therein). The great expectations placed on graphene have resulted in a disappointing eternal promise and borophene emerges as an alternative to overcome graphene [ 144 ]. The potential of both materials is very great, but also the disadvantages of processability and technology needed to reach the levels of polymers.…”

Section: Strength Weakness Opportunities and Threats In Aie Polymentioning

confidence: 99%

Aggregation-Induced Emission Properties in Fully π-Conjugated Polymers, Dendrimers, and Oligomers

et al. 2021

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Aggregation-Induced Emission (AIE) in organic molecules has recently attracted the attention of the scientific community because of their potential applications in different fields. Compared to small molecules, little attention has been paid to polymers and oligomers that exhibit AIE, despite having excellent properties such as high emission efficiency in aggregate and solid states, signal amplification effect, good processability and the availability of multiple functionalization sites. In addition to these features, if the molecular structure is fully conjugated, intramolecular electronic interactions between the composing chromophores may appear, thus giving rise to a wealth of new photophysical properties. In this review, we focus on selected fully conjugated oligomers, dendrimers and polymers, and briefly summarize their synthetic routes, fluorescence properties and potential applications. An exhaustive comparison between spectroscopic results in solution and aggregates or in solid state has been collected in almost all examples, and an opinion on the future direction of the field is briefly stated.

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“…(iii) Compared with other 2D materials, it has highly delocalized bonds due to electron deciency. 28 Consequently, the B-B bond is neither entirely covalent nor metallic, endowing borophene with intriguing electronic, optical, thermal, and chemical properties. 10,12,[29][30][31][32][33][34][35] The bottom-up synthesis of single layer borophene typically requires ultra-high vacuum.…”

Section: Introductionmentioning

confidence: 99%

“…2), and therefore this work has a different focus than the available reviews. [10][11][12][13]15,16,[18][19][20]22,28,30,[40][41][42] Herein the term "functionalization" is dened as the introduction of heterostructures that affects the physical and chemical properties of the boron nanosheets. Specically, the functionalization includes chemical groups, dopants, and strongly interacted composites (Fig.…”

Section: Introductionmentioning

confidence: 99%