Borrelia burgdorferi-associated lymphocytoma cutis simulating a primary cutaneous large B-cell lymphoma

Grange, Florent; Wechsler, Janine; Guillaume, J; Tortel, J.; Tortel, M.-C.; Audhuy, B; Jaulhac, B.; Cerroni, Lorenzo

doi:10.1067/mjd.2002.120475

Cited by 84 publications

(39 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Medical literature includes some cases where patients with pseudolymphoma progressed, after some years, to a malignant lymphoma and death. 15 In a German study with children who presented lymphocytoma cutis and positive serology for Lyme disease, it was noticed that the ECM may precede the appearance of Borrelia lymphocytoma in the majority of the cases, but there are some reports of occurrence of both at the same time. 12 When serial serology was done in our patient, the ELISA and WB patterns changed, as the disease got better.…”

Section: Discussionmentioning

confidence: 99%

Lyme Disease Like Syndrome Associated Lymphocytoma: First Case Report in Brazil

Yoshinari

Spolidorio

Bonoldi

et al. 2007

Clinics

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Lyme Disease Like Syndrome Associated Lymphocytoma: First Case Report in Brazil

Yoshinari

Spolidorio

Bonoldi

et al. 2007

Clinics

View full text Add to dashboard Cite

“…[19][20][21][22][23][24] Furthermore, several independent studies show that Borrelia burgdorferi associated cutaneous marginal B cell lymphoma completely regress following antibiotic treatment. 20,[23][24][25][26] The disappearance of the microorganism following antibiotic treatment is accompanied by a marked decline in the number of plasma cells and CD3 + T cells, strong indicators of active immune responses. 26 These findings support a pathogenic role for Borrelia burgdorferi in sustaining the antigen-driven growth of cutaneous marginal zone B-cell lymphoma, similar to H. pylori infection in gastric MALT lymphoma.…”

Section: Borrelia Burgdorferi and Cutaneous Marginal B Cell Lymphomamentioning

confidence: 99%

MALT Lymphoma : Recent Advances in Aetiology and Molecular Genetics

2007

J Clin Exp Hematopathol

126

View full text Add to dashboard Cite

Mucosa-associated lymphoid tissue (MALT) lymphoma is a common low grade B-cell lymphoma arising from a background of chronic inflammatory disease at a number of mucosal sites. Those originating in the stomach are causatively linked to Helicobacter pylori infection and eradication of the bacterium with antibiotics leads to long-term complete regression of the lymphoma in ∼ 70% of cases. Now, there is further evidence of linking Campylobacter jejuni, Borrelia burgdorferi and Chlamydia psittaci infection with immunoproliferative small intestine disease, MALT lymphoma of the skin and ocular adnexa respectively. t(11;18)/API2-MALT1, t(1;14)/IGH-BCL10, t(14;18)/IGH-MALT1 and t(3;14)/IGH-FOXP1 occur at considerably variable incidences in MALT lymphomas of different sites. The first three chromosome translocations are specifically associated with the MALT lymphoma entity and the oncogenic products of these translocations have been shown to target a common molecular pathway, i.e. the nuclear factor-kB pathway. Here, I review the recent advances in our understanding of the association of microbial pathogens with MALT lymphoma of various sites and the molecular genetics underlying the lymphoma development. 〔J Clin Exp Hematopathol 47(2) : 31-42, 2007〕

show abstract

“…84,91,92 Histologically, borrelial lymphocytoma can be difficult to distinguish from PCBCL, and has led to the improper term of "Borrelia-associated pseudolymphoma." 93 Having in mind the H pylori model of gastric MALT lymphomagenesis, the cutaneous manifestations of Lyme borreliosis could be viewed as a multistep progression from lymphocytoma to "pseudolymphoma" eventually leading to PCBCL. 90,93 Evidence of B-cell monoclonality may help distinguish between the different stages of the disease, 90,93 although it does not constitute a definitive proof of malignancy.…”

Section: Malt Lymphomasmentioning

confidence: 99%

“…93 Having in mind the H pylori model of gastric MALT lymphomagenesis, the cutaneous manifestations of Lyme borreliosis could be viewed as a multistep progression from lymphocytoma to "pseudolymphoma" eventually leading to PCBCL. 90,93 Evidence of B-cell monoclonality may help distinguish between the different stages of the disease, 90,93 although it does not constitute a definitive proof of malignancy.Recently, Chlamydia psittaci infection has also been associated with ocular adnexal MALT lymphomas. 94,95 Adnexal MALT lymphomas have been described in the context of chronic conjunctivitis, and particularly "inclusion conjunctivitis," which can be associated with Chlamydia infection.…”

mentioning

confidence: 99%

Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferation

Suarez

2006

Blood

399

296

View full text Add to dashboard Cite

IntroductionThe geographic heterogeneity in the incidence of B-cell nonHodgkin lymphomas (NHLs) suggests that environmental factors such as infections might have a role in lymphomagenesis. 1,2 Because of the inherent genetic instability of lymphocytes, lymphoid proliferation increases the risk of transformation, and sustained activation of the lymphoid system, which can be observed during chronic infection, immunodeficiency, and autoimmunity, constitutes a risk factor for lymphomas. [3][4][5] Congenital and acquired immunodeficiencies associated with HIV infection and solid organ or hematopoietic transplantation increase the risk of developing B-cell NHLs. 6,7 Similarly, Sjögren syndrome and other autoimmune conditions are also associated with an increased risk of lymphomas. 8,9 Certain types of lymphomas are associated with specific microbial infections, and infection-associated lymphomas currently fall in diverse histopathologic categories (Table 1). 10 Infections may contribute to lymphomagenesis by promoting favorable conditions for lymphocyte transformation, such a increased proliferation or decreased apoptosis of lymphoid cells. 11 Direct lymphocyte transformation by a given microbial agent is the simplest scenario accounting for infection-associated lymphomas. Lymphotropic transforming viruses such as Epstein-Barr virus (EBV), human herpesvirus 8 (HHV8), and human Tlymphotropic virus 1 (HTLV-1) directly infect a subset of lymphoid cells in which they express viral oncogenes. [12][13][14] An alternative scenario to direct transformation of lymphocytes has more recently emerged for microbial species associated with lymphomas but that do not directly infect or transform lymphoid cells. They have in common the ability to persist chronically in host tissues and trigger a sustained lymphoid proliferation, giving a selective advantage to lymphoid clones that still remain dependent upon antigen stimulation. 15,16 According to this model, the microbial pathogen is neither intrinsically transforming nor oncogenic, but can be viewed as a chronic source of antigens increasing the proliferative rate of lymphoid effectors, hence fueling the transformation process. This model has emerged with the description of several lymphomas developing in the context of chronic antigen-dependent immune stimulation, among which H pylori-associated gastric mucosa-associated lymphoid tissue (MALT) lymphoma is the best characterized 15,17,18 (Figure 1). Precise elucidation of the mechanisms underlying this "indirect" lymphomagenesis as well as completion of the inventory of the microbial species driving these antigen-dependent lymphoproliferations may provide important clues for their early diagnosis and the rationalization of the therapeutic interventions for this subtype of lymphomas.This group of lymphomas often involves extranodal sitesnormally devoid of organized lymphoid tissue-and manifests initially as indolent low-grade proliferations, reminiscent of the normal lymphoid hyperplasia driven by a physiologic antigenic stimulation....

show abstract

Borrelia burgdorferi-associated lymphocytoma cutis simulating a primary cutaneous large B-cell lymphoma

Cited by 84 publications

References 17 publications

Lyme Disease Like Syndrome Associated Lymphocytoma: First Case Report in Brazil

Lyme Disease Like Syndrome Associated Lymphocytoma: First Case Report in Brazil

MALT Lymphoma : Recent Advances in Aetiology and Molecular Genetics

Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferation

Contact Info

Product

Resources

About