Borrelia burgdorferi—associated primary cutaneous B cell lymphoma: complete clearing of skin lesions after antibiotic pulse therapy or intralesional injection of interferon alfa-2a

Kütting, Birgitta; Bonsmann, Gisela; Metze, Dieter; Luger, Thomas A.; Cerroni, Lorenzo

doi:10.1016/s0190-9622(97)80405-7

Cited by 173 publications

(99 citation statements)

References 12 publications

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“…Examples include gastric MALT and Helicobacter pylori, 61 splenic MZL and hepatitis C, 62 ocular adnexal MZL and Chlamydophilia psittaci, 63 and cutaneous MZL and Borrelia. 64 Eradication of the implicated microorganism leads to lymphoma regression in many cases, supporting antigenic dependence. 65 The occurrence of secondary genetic lesions, in particular t(11;18), has been associated with poor responses to eradication therapy for gastric MALT lymphoma, presumably due to the development of independence from the microenvironment for growth and survival.…”

Section: Marginal Zone Lymphomamentioning

confidence: 98%

Role of the tumor microenvironment in mature B-cell lymphoid malignancies

Fowler

Cheah

Gascoyne³

et al. 2016

Haematologica

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Section: Marginal Zone Lymphomamentioning

confidence: 98%

Role of the tumor microenvironment in mature B-cell lymphoid malignancies

Fowler

Cheah

Gascoyne³

et al. 2016

Haematologica

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“…Borrelia infection has been documented serologically, and Borrelia-specific DNA has been detected by PCR and Southern blot analysis. [4][5][6][7] In addition, antibiotic therapy has been effective in some cases that were positive for B. burgdorferi. 6,7 Interestingly, this association has been reported mainly from Europe, but rarely from the United States.…”

Section: Primary Cutaneous Marginal Zone B-cell Lymphoma H Takino Et Almentioning

confidence: 99%

“…[4][5][6][7] In addition, antibiotic therapy has been effective in some cases that were positive for B. burgdorferi. 6,7 Interestingly, this association has been reported mainly from Europe, but rarely from the United States. 8,30 We previously reported that such an association is also rare in Asian cases.…”

Section: Primary Cutaneous Marginal Zone B-cell Lymphoma H Takino Et Almentioning

confidence: 99%

“…Evidence suggesting a link between this lymphoma and Borrelia burgdorferi infection has been reported from many European countries including Germany, and penicillin therapy may cure B. burgdorferiassociated cases. [4][5][6][7] However, this association has not been evident in the United States or Asia. 8,9 API2-MALT1 fusion, resulting from t(11;18) (q21;q21) is specific to MALT lymphoma, and has been found in 10-20% of gastric cases and in up to 50% of pulmonary cases, but is rare in autoimmuneassociated cases.…”

mentioning

confidence: 99%

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Primary cutaneous marginal zone B-cell lymphoma: a molecular and clinicopathological study of cases from Asia, Germany, and the United States

Takino

et al. 2008

Modern Pathology

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Primary cutaneous marginal zone B-cell lymphoma is considered the cutaneous counterpart of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Although its molecular pathogenesis is currently unknown, an etiological link with Borrelia burgdorferi infection has been identified in European, but not in American or Asian cases. To better understand the pathogenesis and the geographical differences of cutaneous marginal zone B-cell lymphoma, 60 cases from the East Asia, Germany, and the United States at their initial presentation were subjected to the following analyses; (1) clinicopathological comparison between the geographical regions, (2) detection of B. burgdorferi DNA, (3) detection of the API2-MALT1 fusion transcript, a gene alteration specific to mucosa-associated lymphoid tissue lymphoma, and (4) inactivation of tumor suppressor genes (death-associated protein kinase (DAPK), p16 INK4a , p14 ARF , MGMT, TIMP3, CDH1, and RARB) by hypermethylation of the CpG islands. Cases from the three geographical regions showed similar clinicopathological features. However, moderate/marked tissue eosinophilia was found in 9/25 Asian cases, but only 1/23 German cases (P ¼ 0.011) and 0/12 American cases (P ¼ 0.015). All 60 cases were negative for either Borrelia DNA or API2-MALT1 fusion. Tumors from the three regions were highly methylated for DAPK (38-50% of the cases, mean 43%) and p16 INK4a (42-70%, mean 49%), and the positivities were significantly higher than those of nonneoplastic skin (8%, P ¼ 0.0010 and 14%, P ¼ 0.0032, respectively). Methylation of these genes had no significant association with progressive features of the tumor. Primary cutaneous marginal zone B-cell lymphomas from the three geographical regions have common clinicopathological features, however, moderate/marked tissue eosinophilia is a feature found almost exclusively in Asian cases. Borrelia infection and API2-MALT1 fusion are not significant in this tumor. Methylation of DAPK and p16 INK4a genes is a frequent event in this lymphoma at its initial presentation, but may not be associated with tumor progression.

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“…An association between infectious agents and lymphoma development has been demonstrated for mucosaassociated lymphoid tissue (MALT) lymphomas of the stomach caused by Heliobacter pylori infection and persistent initial primary cutaneous B-cell lymphomas triggered by the Borrelia burgdorferi infection (6,7). Besides bacteria, viruses of the retrovirus and herpes families are possible aetiological agents of human leukaemias and lymphomas, so is Ebstein-Barr virus associated with Burkitt's lymphoma and Hodgkin's lymphoma and a viral cause has been postulated to increase the risk of NHLs in general (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

SV40 and p53 as team players in childhood lymphoproliferative disorders

Heinsohn

Scholz²,

Kabisch³

2011

Int J Oncol

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Abstract. Simian virus 40 (SV40) is known to be potently oncogenic and can induce several types of tumours, such as lymphoma. p53 was discovered as a cellular partner of the SV40 large T-antigen, the oncoprotein of this virus. There have not been many studies on SV40 and p53 in lymphomas and the ones that exist, are controversial. A comparison of these two components in lymphoma has not been reported previously. We exam ined 91 lymphomas [60 B-cell non-Hodgkin's lymphomas (B-NHLs), 19 B-cell acute lymphoblastic leukemias (B-ALLs), 7 B-cell precursor acute lymphoblastic leukemias and 5 T-cell acute lymphoblastic leukemias] for the presence of SV40. Overall, 40 samples from 12 B-NHL/19 B-ALL patients were additionally investigated for p53 mutation in the hot-spot exons 5 to 8. Overall, we found 62/91 lymphomas to be SV40-positive, among them 16/19 B-ALLs and 38/60 B-NHLs. SV40 was absent in 147 of the 149 blood control samples. We found 11 p53 mutations in 19 B-ALL patients: 5 in exon 5 (codons 132, 141, 143, 155 and 181), 4 in exon 7 (codons 236, 238 and 248), 2 in exon 8 (codon 273). In B-NHL patients we found p53-mutations in 9/12 samples: 6 of these in 3 lymph nodes (LNs). One LN harboured 3 different p53 mutations: Exon 5 (codon 132), exon 6 (codon 213) and exon 8 (codon 288). Another LN showed 2 different p53 mutations: Exon 6 (codon 213) and exon 8 (codon 285). Except for 1 nonsense mutation in an LN of a B-NHL patient, all 20 mutations were missense mutations, 2 were homozygous, both found in B-NHLsamples, and one of these (codon 175) is known to cause the global denaturation of p53. All occur in the DNA-binding domain of p53. All specimens showing a p53 mutation, were SV40-positive. p53 mutaions found in LNs of B-NHL patients harbour high SV40 copy numbers. Our data strongly support an important role for SV40, as well as a strong association of SV40 and p53 in childhood lympho-proliferative disorders.

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Borrelia burgdorferi—associated primary cutaneous B cell lymphoma: complete clearing of skin lesions after antibiotic pulse therapy or intralesional injection of interferon alfa-2a

Cited by 173 publications

References 12 publications

Role of the tumor microenvironment in mature B-cell lymphoid malignancies

Role of the tumor microenvironment in mature B-cell lymphoid malignancies

Primary cutaneous marginal zone B-cell lymphoma: a molecular and clinicopathological study of cases from Asia, Germany, and the United States

SV40 and p53 as team players in childhood lymphoproliferative disorders

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