Borrelia Burgdorferi Sensu Lato Infection-induced Autoimmunity – A Decennary Literature Review

Abstract

Borrelia burgdorferi sensu lato is a Gram-negative spirochete that causes Lyme disease (Lyme borreliosis). The signs and symptoms of Lyme disease are a consequence of the immune response to spirochete in soft tissues, and it is debated if said immune response can become an autoimmune disease of the body over time due to bacterial and HLA/MHC molecular mimicry. Continual Lyme Disease (CDL) also known as Post-Treatment Lyme Disease Syndrome (PTLDS) is a broad group of rapidly appearing flu-rash symptoms and cognitive difficulties combined with chronic fatigue that is observed after at least six months after completing treatment. This review contains scientific collections throughout the last 10 years of studies related to alleged post-infection auto-immunogenicity.