Boswellia serrata oleo-gum-resin and β-boswellic acid inhibits HSV-1 infection in vitro through modulation of NF-кB and p38 MAP kinase signaling

Goswami, Debkalpa; Mahapatra, Ananya Das; Banerjee, Subhadip; Kar, Amit; Ojha, Durbadal; Mukherjee, Pulok K.; Chattopadhyay, Debprasad

doi:10.1016/j.phymed.2018.10.016

Cited by 40 publications

(27 citation statements)

References 26 publications

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“…We proceeded to explore the molecular mechanism by which immediate early genes were inhibited by MD. It has been reported that efficient replication of HSV-1 relies on the activation of the NF-κB pathway in the host cell [30–32]. We further tested whether MD suppressed the expression of viral genes by disturbing the NF-κB pathway.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, MD had no effect on the NF-κB signalling pathway. Moreover, the MAPK signalling pathway has also been reported to be involved in the regulation of cytokine production and viral replication [32–34], so we also investigated whether this pathway was affected by MD. We found that MD showed no effect on the activation of ERK and AKT, which are critical components of the MAPK pathway (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The efficient replication of HSV-1 relies on the activation of the NF-κB pathway in host cells. Moreover, it has been reported that the MAPK signalling pathway is also involved in the regulation of cytokine production and viral replication [32]. Therefore, we focused on whether MD inhibits HSV-1 replication by blocking the NF-κB and MAPK pathways.…”

Section: Discussionmentioning

confidence: 99%

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Antiviral activity of mitoxantrone dihydrochloride against human herpes simplex virus mediated by suppression of the viral immediate early genes

et al. 2019

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BackgroundHSV-1 is a common pathogen that infects 50–90% of the human population worldwide. HSV-1 causes numerous infection-related diseases, some of which are severely life-threatening. There are antiviral medications with activity against HSV-1. However, with the emergence of drug-resistant mutant strains of HSV-1, there is an urgent need to develop new effective anti-HSV-1 agents.MethodsTherefore, we screened a chemical library of approximately 1500 compounds to identify inhibitors of HSV-1-induced toxicity for further drug development. Moreover, we performed several experiments, including western blot analysis, Q-PCR analysis and luciferase activity assay, to explore the antiviral mechanism of the candidates.ResultsHere, we identified a small molecule, mitoxantrone dihydrochloride, with potency against HSV-1-induced toxicity. Furthermore, the viral titers and expression levels of HSV-1 viral proteins were potently reduced by the presence of MD in many cell lines. Using Q-PCR analysis, we found that MD efficiently reduced the transcription of viral genes that are essential for DNA synthesis, namely, UL5, UL9, UL29, UL30, UL42 and UL52. Notably, MD also significantly inhibited the transcription of the immediate early genes ICP0, ICP22, ICP27 and ICP47, all of which are required for the expression of early and late viral gene products. Using immunofluorescence and western blot analysis, we found that the antiviral effect of MD was independent of the activation of the NF-κB and MAPK pathways. Furthermore, we found that the reduction in the transcription of viral immediate early genes was not related to the promoter activities of ICP0.ConclusionsTherefore, the identification of compound MD as an inhibitor of toxicity induced by HSV-1 highlights its potential use in the development of novel anti-HSV-1 drugs.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Antiviral activity of mitoxantrone dihydrochloride against human herpes simplex virus mediated by suppression of the viral immediate early genes

et al. 2019

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“…Furthermore, vesicular stomatitis virus vector particles and viral infections were also reduced, thereby demonstrating its broad antiviral activity [143]. An in vitro study was performed to explore the ethnomedicinal use of BSE, and it was proved that BSE, as well as BA, efficiently inhibited wild-type and a clinical isolate of HSV-1 via alteration of NF-κB and p38 MAPK pathways [157]. Furthermore, in another study on a mouse model of LPS-induced neuroinflammation, AKBA played a significant role in counteracting the symptoms via modulation of miRNA-155 [161].…”

Section: Potential Role Of Bas In the Treatment Of Chronic Diseasesmentioning

confidence: 99%

An Update on Pharmacological Potential of Boswellic Acids against Chronic Diseases

Roy

Dey

Banik

et al. 2019

IJMS

164

117

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Natural compounds, in recent years, have attracted significant attention for their use in the prevention and treatment of diverse chronic diseases as they are devoid of major toxicities. Boswellic acid (BA), a series of pentacyclic triterpene molecules, is isolated from the gum resin of Boswellia serrata and Boswellia carteri. It proved to be one such agent that has exhibited efficacy against various chronic diseases like arthritis, diabetes, asthma, cancer, inflammatory bowel disease, Parkinson’s disease, Alzheimer’s, etc. The molecular targets attributed to its wide range of biological activities include transcription factors, kinases, enzymes, receptors, growth factors, etc. The present review is an attempt to demonstrate the diverse pharmacological uses of BA, along with its underlying molecular mechanism of action against different ailments. Further, this review also discusses the roadblocks associated with the pharmacokinetics and bioavailability of this promising compound and strategies to overcome those limitations for developing it as an effective drug for the clinical management of chronic diseases.

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“…These sores usually occur either around the mouth and nose, or on the genitals and buttocks. Several extracts were described with antiviral activity [43] including licorice extract [44] and Boswellia serrata oleo gum [45]. However clinical studies using these plant products are still missing.…”

Section: Herpes Simplexmentioning

confidence: 99%

New Herbal Biomedicines for the Topical Treatment of Dermatological Disorders

et al. 2020

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Herbal extracts and isolated plant compounds play an increasing role in the treatment of skin disorders and wounds. Several new herbal drugs, medicinal products and cosmetic products for the treatment of various skin conditions have been developed in recent years. In this nonsystematic review, we focus on herbal drugs that were tested in controlled clinical studies or in scientifically sound preclinical studies. The herbal biomedicines are intended to treat atopic dermatitis (St. John’s wort, licorice, tormentil, bitter substances, evening primrose), psoriasis (araroba tree, lace flower, barberry bark, indigo, turmeric, olibanum, St. John’s wort), actinic keratosis (birch bark, petty spurge), herpes simplex (lemon balm, sage and rhubarb), rosacea (green tea, licorice, tormentil) and acne vulgaris (tea tree oil, green tea, hop), or to improve photo protection (green tea, Dyer’s weed, cocoa tree, carotinoids, licorice), aesthetic dermatology (licorice, pine bark, gotu kola) and wound healing (birch bark, onion).

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Boswellia serrata oleo-gum-resin and β-boswellic acid inhibits HSV-1 infection in vitro through modulation of NF-кB and p38 MAP kinase signaling

Cited by 40 publications

References 26 publications

Antiviral activity of mitoxantrone dihydrochloride against human herpes simplex virus mediated by suppression of the viral immediate early genes

Antiviral activity of mitoxantrone dihydrochloride against human herpes simplex virus mediated by suppression of the viral immediate early genes

An Update on Pharmacological Potential of Boswellic Acids against Chronic Diseases

New Herbal Biomedicines for the Topical Treatment of Dermatological Disorders

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