Botanical Therapeutics for Parkinson’s Disease

Li, Wen-Wei

doi:10.1007/s11655-020-3096-5

Cited by 4 publications

(4 citation statements)

References 71 publications

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“…[40] Li et al and Ramig et al reported that with the individuals with PD who undergo intensive speech treatment, the VHI score was reduced by 35.23%, irregular phonation, breathy voice, weak phonation, tense dysphonia were improved, the discomfort of the larynx was reduced, and the patient could communicate naturally in daily life with benign emotional reactions, and social participation capacity was gradually increased. [44,45]…”

Section: Relevant Evidence For Efficacy Of Intensive Speech Treatmentmentioning

confidence: 99%

“…This finding suggests that PD patients have reduced voice frequency range, which also provides a basis for explaining their monotonous intonation and reduced prosody. A study by Li et al [44] investigated the effect of intensive speech treatment on Mandarin speakers with PD. They found that voice loudness in monologue and reading was significantly increased in the treatment group, which increased the output of speech and promoted the effective communication in daily life.…”

Section: Relevant Evidence For Efficacy Of Intensive Speech Treatmentmentioning

confidence: 99%

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Effects of intensive speech treatment on Mandarin speakers with Parkinson’s Disease: A review

Chen

Wan

et al. 2023

Medicine

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Background: Benefits of intensive speech treatment have been documented for a range of speech signs in English speakers with Parkinson’s Disease (PD). However, the answer to a critical question that whether the same treatment benefits speech variables including intelligibility in Mandarin speakers is still unclear. In order to develop a targeted speech treatment for Mandarin speakers with PD, we reviewed the efficacy of intensive speech treatment to improve vocal loudness and functional communication and discuss possible explanations for efficacy on Mandarin speakers with PD. Methods: Literatures about intensive speech treatment for Mandarin speakers with PD were retrieved from PubMed, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), Wanfang and Weipu Database for Chinese Technical Periodicals (VIP) Database. Search strategy was (voice therapy OR speech therapy OR voice treatment OR speech treatment OR voice training OR speech training OR voice rehabilitation OR speech rehabilitation OR Lee Silverman voice treatment OR intensive speech treatment) and (Parkinson’s disease) and (Mandarin speakers OR Chinese OR Chinese people). Results: Five randomized controlled trials were selected and possible explanations for efficacy on individuals with PD are discussed. Further research directions are suggested. Conclusion: The existing evidence from treatment efficacy studies of intensive speech treatment provides support for improving vocal loudness, speech intelligibility, pitch and rate in Mandarin speakers with PD. Our future research will continue to work to conduct a large sample multicenter randomized controlled trial to provide high quality evidence and understand the basic mechanisms accompanying treatment-related change.

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Section: Relevant Evidence For Efficacy Of Intensive Speech Treatmentmentioning

confidence: 99%

Section: Relevant Evidence For Efficacy Of Intensive Speech Treatmentmentioning

confidence: 99%

Effects of intensive speech treatment on Mandarin speakers with Parkinson’s Disease: A review

Chen

Wan

et al. 2023

Medicine

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“…After two weeks of adaptive feeding, the mice were held in the rotarod test instrument to remove the individuals with movement problems. Then, seven experimental groups of mice (n = 10) were studied: (1) Control group: saline injection plus saline oral administration; (2) MPTP group: MPTP injection plus saline; (3) Gp-low dosage group (Gp-L): MPTP injection plus Garlic powder 13mg/kg/day; (4) Gp-middle dosage group (Gp-M): MPTP injection plus Gp 26mg/kg/day; (5) Gp-high dosage group (Gp-H): MPTP injection plus Gp 52mg/kg/day; (6) Positive Control group: MPTP injection plus Madopar 1.0mg/kg/day; (7) Control group with Gp: saline injection plus Gp 52mg/kg/day. In the rst seven days, The Control group was intraperitoneally injected with saline while the experimental group was injected with MPTP (20 mg/kg).…”

Section: Animals and Treatmentsmentioning

confidence: 99%

“…In the current clinical treatment, levodopa is usually used to improve to increase dopamine, but signi cant long-term side effects cannot be ruled out for synthetic drugs [6] . Natural products and herbs have shown signi cant effects in alleviating neurodegenerative diseases [7] . Garlic is an edible plant from onion species, which is widely used in cooking all over the world.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of Garlic Powder on MPTP-induced dopaminergic neurodegeneration by activation of Nrf2-HO1 and mitochondrial dynamics

Shi

Yuan

et al. 2023

Preprint

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Parkinson's disease (PD) is implicated for dopaminergic neurodegeneration. Previously, research shows garlic has been shown to have potent neuroprotective effect, especially antioxidant activity on several disease models. To investigate the protective effect of Garlic powder against 1-methyl-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD model, 2 months old C57BL/6 mice received intraperitoneal injection of MPTP (20 mg/kg) during the first 7 days of treatment. Garlic powder were given, respectively, by 13mg/kg, 26mg/kg, 52mg/kg (oral formulation) for 30 days continuously. Our data showed that Garlic powder decreased MPTP-induced behavioral impairments, alleviating dopaminergic neuron loss and mitochondrial damage as well as oxidative stress. Further, in vitro study, Garlic powder effectively decreased MPP+ (2mM)-induced oxidative stress in N2a cells. Moreover, treatment of Nrf2 inhibitor ML-385 (5µM) inhibited Garlic powder induced protective effect on cell under stress. These results indicated that Garlic powder can rescue the mitochondrial damage and oxidative stress in the substantia nigra in PD mouse model and N2a cells by Nrf2-HO1 signaling pathway and mitochondrial dynamics. Garlic powder shows neuroprotective effects in PD treatment.

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Acupuncture Therapy on Dysphagia in Patients with Parkinson’s Disease: A Randomized Controlled Study

Zeng,

Zhao,

Luo

et al. 2024

Chin. J. Integr. Med.

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Botanical Therapeutics for Parkinson’s Disease

Cited by 4 publications

References 71 publications

Effects of intensive speech treatment on Mandarin speakers with Parkinson’s Disease: A review

Effects of intensive speech treatment on Mandarin speakers with Parkinson’s Disease: A review

Inhibitory effect of Garlic Powder on MPTP-induced dopaminergic neurodegeneration by activation of Nrf2-HO1 and mitochondrial dynamics

Acupuncture Therapy on Dysphagia in Patients with Parkinson’s Disease: A Randomized Controlled Study

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