Botanical, Traditional Use, Phytochemical, and Toxicological of Arisaematis rhizoma

Qi, Chun-Yan; Jing, Wang; Wu, Xu; He, Surong; Zhang, Qiao; Ju, Wu; Zhao, Chongbo

doi:10.1155/2021/9055574

Cited by 9 publications

(7 citation statements)

References 13 publications

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“…Ziyin Pingchan Decoction includes seven herbs and worms, namely, Rehmanniae radix praeparata (Shudihuang) 15 g, Lycii fructus (Gouqizi) 12 g, Taxilli herba (Sangjisheng) 15 g, Gastrodiae rhizoma (Tianma) 9 g, Paeoniae radix alba (Baishao) 15 g, Bombyx batryiticatus (Jiangcan) 9 g, and Scorpio (Quanxie) 3 g. Jiedu Pingchan Decoction is the Ziyin Pingchan Decoction with two additional herbs, namely, Arisaematis rhizoma preparatum (Zhitiannanxing) 15 g and Curcumae rhizoma (Ezhu) 9 g. Fuzheng Pingchan Decoction consists of Ziyin Pingchan Decoction and two extra herbs, namely, Astragali radix (Huangqi) 30 g and Cistanches herba (Roucongrong) 30 g. The doses of each herb and worm were determined according to The Chinese Pharmacopoeia (Ch. P) 2020 edition and fixed by clinical experience within a safe dose [ 26 , 27 ].…”

Section: Methodsmentioning

confidence: 99%

Traditional Chinese medicine syndrome differentiation and treatment by stages of Parkinson’s disease: study protocol for a multicentre, randomized, double-blind, placebo-controlled clinical trial

Yuan

et al. 2022

Chin Med

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Background Parkinson’s disease (PD) is a progressive neurodegenerative disease common in aged populations. Classified by Hoehn & Yahr stages, patients are often divided into mild/early stage, moderate/middle stage, and advanced/late stage. With disease progression, PD shows high heterogeneity in each stage. Based on traditional Chinese medicine (TCM) syndrome differentiation theory and our previous works, we found that during the early stage, the main syndrome is Yin deficiency of the liver and kidney; during the moderate stage, the main syndromes are phlegm heat and wind stirring and blood stasis and wind stirring; and during the late stage, the dominant syndromes are deficiency of Yin and Yang and deficiency of Qi and blood. Hence, we proposed a new model of TCM treatment by the stage of PD. Based on Shudi Pingchan formula, an experimental formula of our team, we developed Ziyin Pingchan formula, Jiedu Pingchan formula, and Fuzheng Pingchan formula to treat each stage. This study is designed to evaluate the therapeutic effect of treating Parkinson’s disease by stages using traditional Chinese medicine and to provide an evidence base for forming a standardized scheme of diagnosis and treatment. Methods This study is designed as a multicentre, randomized, double-blind, placebo-controlled clinical trial. Patients will be stratified into 3 subgroups according to Hoehn & Yahr stage; 172, 168, and 72 participants will be required to be in the mild PD, moderate PD, and advanced PD subgroups, respectively, and will be randomized into the treatment or control group at a 1:1 ratio. The mild PD subgroup will receive a 48-week intervention, and the other 2 groups will receive a 24-week intervention. All groups will have a follow-up visit 12 weeks after starting the intervention. The intervention group will receive the Ziyin Pingchan formula, Jiedu Pingchan formula, or Fuzheng Pingchan formula, and the control group will receive the corresponding placebo. The primary outcomes will be the first addition of levodopa for the mild PD subgroup, the duration of the “OFF” period for the moderate PD subgroup, and the Parkinson's Disease Questionnaire (PDQ-39) for the advanced PD subgroup. The secondary outcomes will also be verified by subgroups, including the Unified Parkinson’s Disease Rating Scale (UPDRS), Parkinson’s Disease Sleep Scale-2 (PDSS-2), scales for Outcomes in Parkinson’s Disease—Autonomic (SCOPA-AUT), and the nonmotor symptom scale (NMSS). Expected outcomes To our knowledge, this is the first trial to combine TCM syndrome differentiation with PD clinical stages and put it into clinical practice. The results of this trial will provide clinical evidence for the therapeutic effect of TCM formulas on PD patients of all stages and help build a new TCM treatment by stage model of PD. Trial registration: This trial is registered at the Chinese Clinical Trial Registry (http://www.chictr.org.cn/). Registration number: ChiCTR2200056373, Date: 2022–02-04, version 1.

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Section: Methodsmentioning

confidence: 99%

Traditional Chinese medicine syndrome differentiation and treatment by stages of Parkinson’s disease: study protocol for a multicentre, randomized, double-blind, placebo-controlled clinical trial

Yuan

et al. 2022

Chin Med

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“…A família possui diversos usos na medicina popular, como é o exemplo do Rhizoma Arisaematis (RA, o rizoma de Pinellia pedatisecta Schott), que possui grande importância na medicina tradicional chinesa. E por esta razão, nos últimos anos, muitos especialistas estão constantemente desenvolvendo pesquisas com o grupo e fizeram grandes contribuições em muitos aspectos; como medicina tradicional chinesa, a RA contém glicosídeos, açúcares, flavonóides, alcalóides, saponinas e outros componentes químicos com efeitos expectorantes, anti-inflamatórios, anticonvulsivantes, antitumorais e outros efeitos farmacológicos (QI et al, 2021). O autor afirma, ainda, que no processo de pesquisa contínua existem novos problemas e desafios que precisam de mais pesquisas e estudos.…”

Section: Descritoresunclassified

Mapeamento científico e tecnológico de Araceae Juss.: Uma projeção para as atividades biológicas

Val¹,

Costa

Souza

et al. 2022

RSD

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Araceae Juss é uma família com grande potencial químico e biológico devido aos seus usos etnofarmacológicos e propriedades químicas. Este estudo, portanto, trata-se de uma prospecção científica e tecnológica em bases internacionais de dados de artigos e patentes sobre a atividade biológica de Araceae. A Índia é o país com maior número de pesquisas científicas com 28 registros, com maior número na Scopus (23), A China e os Estados Unidos estão em segunda e terceira posição, respectivamente, enquanto o Brasil encontra-se em quarta posição. As áreas com maior número de trabalhos indexados foram Farmácia, Toxicologia e Farmacêutica (23,6 %) seguida de Ciências Ambientais (22, 1%) e Agricultura e Ciências Biológicas (11, 6%). Os pedidos de depósitos de patentes tiveram início em 1949 (n=1), atingindo limiar em 2020 (n=153), tendo como base a EPO. A China é o país com maior número de produção tecnológica envolvendo as atividades biológicas do táxon com 713 indexações, seguida de Estados Unidos da América (n=378) e Japão (n=150), enquanto o Brasil apresentou apenas 13 patentes publicadas. Em relação a CIP 252 patentes compreendem a subclasse C12N15. Conclui-se que as atividades biológicas da família estão sendo fonte para diversas pesquisas, porém, o Brasil como sendo um país com grande diversidade da família, se apresenta bem abaixo no número de publicações, o que se deve ao fato de pouca colaboração entre empresas e instituições e também pela demora no registro de patentes no país.

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“…Similarly, Cinnamon has been proven to have great antibacterial capacity Rhizoma A. has extensive pharmacological activities, which include antitumor, anti-inflammation, anticonvulsant, and antibacterial activities . Also, Cortex A., Piper L., and Angelica D. have outstanding anti-inflammatory activity and are often used as therapeutic candidates for inhibiting inflammation-mediated diseases. − …”

Section: Introductionmentioning

confidence: 99%

Novel Hydrogel Adjuvant of Chinese Medicine External Preparations for Accelerated Healing of Deep Soft Tissue Injuries

Wang,

Xia,

et al. 2024

ACS Biomater. Sci. Eng.

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Traditional Chinese medicine external prescriptions have displayed excellent clinical effects for treating deep soft tissue injuries. However, the effects cannot be fully utilized due to the limitations of their dosage forms and usage methods. It is still a challenge to develop a satisfactory adjuvant of traditional Chinese medicine external prescriptions. Herein, a hydrogel adjuvant was prepared based on gallic acid coupled ε-poly-L-lysine and partially oxidized hyaluronic acid. The resulting adjuvant shows great physicochemical properties, low hemolysis rate (still much less than 5% at 5 mg/mL), excellent antibacterial ability (about 95% at 2 mg/mL), strong antioxidant ability (1.687 ± 0.085 mmol FeSO 4 /(g hydrogel) at 1 mg/mL), as well as outstanding biocompatibility. A clinically used Chinese medicine external preparation was selected as an example to investigate the effectiveness of the adjuvant in treating deep soft tissue injuries. The results show that the prescription can be evenly dispersed in the adjuvant. Moreover, the introduction of the prescription has not significantly changed these advanced properties of the adjuvant. Importantly, the hydrogel adjuvant significantly improves the effectiveness of the prescription in treating deep soft tissue injuries. This work offers an alternative approach to the development of a new-type adjuvant of Chinese medicine external preparations and also provides a new strategy for the combination of traditional Chinese medicine and hydrogel to treat clinical diseases.

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Botanical, Traditional Use, Phytochemical, and Toxicological of Arisaematis rhizoma

Cited by 9 publications

References 13 publications

Traditional Chinese medicine syndrome differentiation and treatment by stages of Parkinson’s disease: study protocol for a multicentre, randomized, double-blind, placebo-controlled clinical trial

Traditional Chinese medicine syndrome differentiation and treatment by stages of Parkinson’s disease: study protocol for a multicentre, randomized, double-blind, placebo-controlled clinical trial

Mapeamento científico e tecnológico de Araceae Juss.: Uma projeção para as atividades biológicas

Novel Hydrogel Adjuvant of Chinese Medicine External Preparations for Accelerated Healing of Deep Soft Tissue Injuries

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