Both hypothyroidism and hyperthyroidism increase plasma irisin levels in rats

Atıcı, Emine; Moğulkoç, Rasim; Baltacı, Abdülkerim Kasım; Menevşe, Esma

doi:10.1515/hmbci-2017-0054

Cited by 14 publications

(17 citation statements)

References 26 publications

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“…Atici et al. 27,28 found that irisin levels were increased in rats with hypothyroidism and hyperthyroidism. Short-term iatrogenic hypothyroidism was induced by daily intraperitoneal administration of 6-N-propyl-2-thiouracil (10 mg/kg/day) for 3 weeks.…”

Section: Discussionmentioning

confidence: 99%

Role of irisin in Chinese patients with hypothyroidism: an interventional study

et al. 2019

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Objective Irisin is a myokine that greatly affects energy expenditure and systemic metabolism. While thyroid hormone is likely associated with irisin, a direct relationship remains to be fully elucidated. This study aimed to investigate plasma irisin levels in Chinese patients with hypothyroidism. Methods A total of 155 subjects were divided into the hypothyroidism group or the control group. Fifty-seven patients in the hypothyroidism group received levothyroxine treatment. Baseline irisin levels were measured in the two groups and post-treatment levels were measured in the hypothyroidism group. Results Irisin levels were significantly lower in the hypothyroidism group than in the control group. In the hypothyroidism group, irisin levels were positively associated with free triiodothyronine and free thyroxine levels, and negatively associated with thyrotropin levels. In the hypothyroidism group, irisin levels were significantly increased after levothyroxine treatment. Multiple linear regression models showed that total cholesterol and free thyroxine levels were the only significant predictors of serum irisin levels. Conclusions Irisin levels are decreased in patients with hypothyroidism. Our results suggest that decreased irisin levels are directly associated with reduced thyroid hormone levels. These values may be restored after levothyroxine treatment in Chinese patients with hypothyroidism.

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Section: Discussionmentioning

confidence: 99%

Role of irisin in Chinese patients with hypothyroidism: an interventional study

et al. 2019

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“…A meta-analysis of 55,287 participants indicated that SCH is associated with an increased risk of coronary heart disease (CHD) and mortality in those with higher TSH levels, in particular in those with TSH levels at 10 mIU/L or greater [25]. Some studies have shown that some adipokines or hepatokines, such as Irisin and FGF21 levels, are altered in thyroid dysfunction [14, 26, 27]. Because the associations between Angptl and SCH or CH are not clear, we sought to understand the potential role of Angptl3, 4, and 8 on these diseases.…”

Section: Discussionmentioning

confidence: 99%

Circulating Angptl3 and Angptl8 Are Increased in Patients with Hypothyroidism

Yang

Yin

Wang

et al. 2019

BioMed Research International

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Purpose. Angiopoietin-like proteins (Angptls) play critical roles in biological processes, primarily in lipid metabolism. The functional state of the thyroid has a profound influence on metabolism in the human body. Therefore, the aim of this study was to investigate possible changes in serum Angptl3, 4, and 8 levels in hypothyroid patients. Methods. The study included 29 patients with clinical hypothyroidism, 30 patients with subclinical hypothyroidism, and 29 healthy subjects. Baseline clinical indices, including serum thyroid function tests, were recorded and serum Angptl3, 4, and 8 levels were measured across the three groups. Results. Serum Angptl3 and 8 levels were significantly higher in the hypothyroid groups compared to the control group (p < 0.05). There were no differences in Angptl4 levels among the three groups (p > 0.05). Positive correlations were identified between Angptl3 and high-density lipoprotein cholesterol (r = 0.431, p < 0.001), and there was a negative correlation between Angptl3 and total tri-iodothyronine (TT3) (r = -0.220, p = 0.047) and free tri-iodothyronine (r = - 0.279, p = 0.013) levels. Angptl8 was positively correlated with triglyceride (r = 0.267, p = 0.012) and cholesterol levels (r= 0.235, p = 0.028) but was negatively correlated with tri-iodothyronine (r = -0.24, p = 0.031). Furthermore, we used receiver operating characteristic curve analysis to evaluate the diagnostic performance of Angptl3 and 8 in discriminating thyroid dysfunction. The area under curve for detecting thyroid dysfunction based on Angptl3 and Angptl8 was 0.763. Conclusions. Our data show that serum Angptl3 and 8 levels are increased in clinical and subclinical hypothyroid patients and that Angptl3 and 8 may serve as possible biomarkers of hypothyroid disease.

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“…However, based on a recently published research that used human subcutaneous white adipocytes, irisin and T3 might have different influences on adiponectin, PPAR-γ, and FNDC5 levels [16]. Animal studies have shown that the hypothalamic-pituitary-thyroid (HPT) axis function may be directly or indirectly related to irisin modulation, or vice versa [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Circulating Irisin Level and Thyroid Dysfunction: A Systematic Review and Meta-Analysis

Shan

Zou

Liu

et al. 2020

BioMed Research International

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Both thyroid hormones and irisin have profound influences on the metabolism of the human body. Based on their similarities, several studies have been conducted to explore changes in irisin levels in patients with hypothyroidism and hyperthyroidism. This study was conducted in accordance with the PRISMA statement and the MOOSE reporting guideline. Based on a preregistered protocol (PROSPERO—CRD42019138430), a comprehensive search of eight databases was performed from inception to April 2020. Studies with original data collected from patients with thyroid dysfunction were included. Subgroup analysis was performed based on the different types of clinical manifestations and patient characteristics. The quality of each study and the presence of publication bias were assessed by the Newcastle-Ottawa score (NOS) and funnel plot with Egger’s test, respectively. A total of 11 studies with 1210 participants were included. Ten studies were identified as high-quality studies. Pooled analysis indicated decreased irisin levels in patients with hypothyroidism (MD -10.37, 95% CI -17.81 to -2.93). Subgroup analysis revealed an even lower level of irisin in patients with clinical-type hypothyroidism (MD -17.03, 95% CI -30.58 to -3.49) and hypothyroidism caused by autoimmune disease (MD -19.38, 95% CI -36.50 to -2.26). No differences were found after achieving euthyroid status from levothyroxine treatment in patients with hypothyroidism compared with controls. No differences were found between patients with hyperthyroidism and controls. Correlation analyses revealed a possible negative correlation between irisin and TSH and positive correlations between irisin and both fT3 and fT4. Irisin was correlated with TSH receptor antibodies.

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Both hypothyroidism and hyperthyroidism increase plasma irisin levels in rats

Cited by 14 publications

References 26 publications

Role of irisin in Chinese patients with hypothyroidism: an interventional study

Role of irisin in Chinese patients with hypothyroidism: an interventional study

Circulating Angptl3 and Angptl8 Are Increased in Patients with Hypothyroidism

Circulating Irisin Level and Thyroid Dysfunction: A Systematic Review and Meta-Analysis

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