2020
DOI: 10.1155/2020/2182735
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Circulating Irisin Level and Thyroid Dysfunction: A Systematic Review and Meta-Analysis

Abstract: Both thyroid hormones and irisin have profound influences on the metabolism of the human body. Based on their similarities, several studies have been conducted to explore changes in irisin levels in patients with hypothyroidism and hyperthyroidism. This study was conducted in accordance with the PRISMA statement and the MOOSE reporting guideline. Based on a preregistered protocol (PROSPERO—CRD42019138430), a comprehensive search of eight databases was performed from inception to April 2020. Studies with origin… Show more

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Cited by 4 publications
(2 citation statements)
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“…We discovered that irisin levels were significantly reduced in the severe hypothyroidism group than in controls. Consistent with results shown in the current trial, a recent meta-analysis revealed that the levels of irisin are lower in hypothyroidism patients [ 30 ]. In contrast, a case-control research showed that circulating irisin concentrations were elevated in hypothyroidism [ 27 ].…”
Section: Discussionsupporting
confidence: 91%
“…We discovered that irisin levels were significantly reduced in the severe hypothyroidism group than in controls. Consistent with results shown in the current trial, a recent meta-analysis revealed that the levels of irisin are lower in hypothyroidism patients [ 30 ]. In contrast, a case-control research showed that circulating irisin concentrations were elevated in hypothyroidism [ 27 ].…”
Section: Discussionsupporting
confidence: 91%
“…Moreover, to the best of our knowledge, no previous study has evaluated the relationship between the irisin level and thyroid autoantibodies. 19 Therefore, we performed a cross-sectional study to evaluate serum irisin and CK levels among patients with isolated SH, isolated TAA positivity, TAA positivity plus SH, and healthy controls.…”
Section: Introductionmentioning
confidence: 99%