Both Prevalence and Severity of Pruritus are Associated with Age in Chinese Patients with Skin Diseases

Wang, Xiaohua; Lai, Qingsong; Zheng, Boyang; Li, Ye; Wen, Shusheng; Yan, Yi; Yang, Bin; Man, Mao‐Qiang

doi:10.2147/ccid.s300458

Cited by 9 publications

(12 citation statements)

References 26 publications

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“…This method can also detect a single mutation in the virus and provide detection results in about one hour. This evidence shows that this method can be a breakthrough in virus detection tools, especially the SARS-CoV-2 virus (Lotfi and Rezaei, 2020;Wang et al, 2021).…”

Section: Research Evidence Of Sherlock As a New Methods For Detecting...mentioning

confidence: 88%

Amplification genetic engineering strategy by Crispr-Cas13 Enzymes for detection and treatment COVID-19 mediated with gold nanoparticle (AUNP)

Rafidah

Rahmanto²,

Pratiska³

2022

Qanun Medika

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WHO declared the disease outbreak due to the COVID-19 coronavirus a global pandemic. Indonesian government's efforts to eradicate the pandemic through mass screening have not been effective due to the limitations of the three main modalities used to detect COVID-19, including Rapid Test Diagnostic (RTD) antibodies, RTD antigens, and Reverse Transcriptase-Polymerase Chain Reaction (RT-RTD PCR), In addition, other detection tools are sometimes used, such as Enzyme-Linked Immunosorbent Assay (ELISA) and rapid molecular tests. To eradicate this pandemic, the government needs COVID-19 detection tools that are effective, cheap, fast, and accessible. To determine the application of the genetic engineering strategy of amplification by the CRISPR-cas13 enzyme for detecting and treating COVID-19 mediated by gold nanoparticles (AuNP). This research uses a qualitative literature study with content analysis, observation development, and literature study; an alternative solution to this problem is CRISPR-Cas13, achieved by the SHERLOCK method. This method designs and screens a targeted group of CRISPR RNAs based on the identification of functional crRNAs of SARS-CoV-2. Amplification of CRISPR-Cas13 by SHERLOCK and PAC-MAN enzymes has the potential to be the latest detection and treatment method for gold nanoparticle-mediated COVID-19 (AuNP) in Indonesia.

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Section: Research Evidence Of Sherlock As a New Methods For Detecting...mentioning

confidence: 88%

Amplification genetic engineering strategy by Crispr-Cas13 Enzymes for detection and treatment COVID-19 mediated with gold nanoparticle (AUNP)

Rafidah

Rahmanto²,

Pratiska³

2022

Qanun Medika

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“…4 Sebuah studi di Cina menunjukkan bahwa prevalensi dan intensitas pruritus ditemukan lebih tinggi pada pasien dengan dermatitis eksim atau urtikaria dibandingkan dengan penyakit kulit lainnya. 5 Studi lain yang dilakukan di Amerika Serikat selama 11 tahun menunjukkan bahwa terdapat 11 juta kunjungan untuk keluhan gatal dengan rerata 7 juta kunjungan setiap tahunnya. Keluhan gatal ini muncul kurang lebih pada 1% dari keseluruhan kunjungan ke dokter.…”

Section: Epidemiologiunclassified

Pruritus dan modalitas terapi terkini: Sebuah tinjauan pustaka

Novena¹,

Ariani²

2021

Intisari Sains Medis

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Pruritus or itching is an unpleasant feeling that causes the urge to scratch, the most common symptom found in skin diseases. Histamine and several other mediators such as opioid peptides and 5-hydroxytryptamine (5-HT) also influence the occurrence of pruritus. The prevalence of pruritus in the general population varies from 8% to 38% worldwide. Pruritus is categorized into 4 types, neuropathic, psychogenic, neurogenic, and pruriroceptive pruritus. When physically examining the skin, primary skin lesions must be distinguished from secondary lesions due to chronic scratching. Dermatological signs of chronic scratching include excoriation, lichenification, prurigo nodularis or a combination of these. Management of pruritus depends on the underlying etiology. Therapy should be focused on the underlying etiology. There are pharmacological and non-pharmacological therapies, where non-pharmacological therapies focus on avoiding precipitating factors and phototherapy. Pharmacological therapy can be in the form of topical and oral therapy. Some examples of topical therapies used in daily practice are emollients, corticosteroids, immunomodulators, capsaicin, antihistamines and topical anesthetics. Oral drugs that are currently the main choice for treating pruritus are antihistamines, but there are several other options being considered, namely anticonvulsants, opioid modulators, and antidepressants. A comprehensive history and physical examination are needed to determine the triggering factors for the onset of pruritus. The management of pruritus depends on the underlying etiology and the success of therapy is also influenced by the patient's adherence to treatment. Treatment of pruritus can be in the form of non-pharmacological therapy and pharmacological therapy. Pharmacological therapy can be both topical and systemic. Commonly used topical therapies are emollients, corticosteroids and topical anesthetics. Antihistamines remain the mainstay of systemic therapy used for pruritus. The purpose of writing this article is to discuss more deeply about the treatment modalities of pruritus which are summarized from various journals and research in order to provide consideration when choosing the right therapy in daily practice. Pruritus atau rasa gatal adalah perasaan tidak menyenangkan yang menyebabkan keinginan untuk menggaruk merupakan gejala yang paling umum ditemukan pada penyakit kulit. Histamin dan beberapa mediator lainnya seperti peptida opiod dan 5-hidroksitriptamin (5-HT) juga memengaruhi terjadinya pruritus. Prevalensi pruritus pada populasi umum bervariasi mulai dari 8% sampai dengan 38% di seluruh dunia. Pruritus dikategorikan menjadi 4 tipe, yaitu pruritus neuropatik, psikogenik, neurogenik, dan pruriroseptif. Saat memeriksa kulit secara fisik, lesi kulit primer harus dibedakan dari lesi sekunder akibat garukan kronis. Tanda-tanda dermatologis dari garukan kronis termasuk ekskoriasi, likenifikasi, prurigo nodularis atau kombinasi dari semuanya. Penatalaksanaan pruritus bergantung pada etiologi yang mendasari. Terapi yang diberikan harus difokuskan pada etiologi yang mendasari. Terdapat terapi farmakologi dan non-farmakologi, dimana terapi non farmakologi fokus terhadap menghindari faktor pencetus serta fototerapi. Terapi farmakologi dapat berupa terapi topikal dan oral. Beberapa contoh terapi topikal yang digunakan dalam praktik sehari-hari adalah emolien, kortikosteroid, imunomodulator, capsaisin, antihistamin dan anestesi topikal. Obat oral yang hingga saat ini menjadi pilihan utama terapi pruritus adalah antihistamin, namun terdapat beberapa pilihan lain yang dipertimbangkan yaitu antikonvulsan, modulator opioid, antidepresan. Anamnesis dan pemeriksaan fisik yang komprehensif sangat diperlukan untuk mengetahui faktor pencetus timbulnya pruritus. Penatalaksanaan pruritus bergantung pada etiologi yang mendasari dan keberhasilan terapi juga dipengaruhi oleh ketaatan pasien dalam berobat. Terapi pruritus dapat berupa terapi non-farmakologis dan terapi farmakologis. Terapi farmakologis dapat berupa topikal dan sistemik. Terapi topikal yang umum digunakan adalah emolien, kortikosteroid dan anestesi topikal. Antihistamin tetap menjadi pilihan utama terapi sistemik yang digunakan untuk pruritus. Penulisan artikel ini bertujuan untuk membahas lebih dalam tentang modalitas terapi pruritus yang dirangkum dari berbagai jurnal serta penelitian agar dapat memberikan pertimbangan saat memilih terapi yang tepat dalam praktik sehari-hari.

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“…Both allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD) have been reported 6 , 7 . The incidence of PPD related ACD, an occupational-related, positive patch test reaction to PPD, is about 4.80% in outpatients with occupational exposure to PPD such as hairdressers, barbers 8 . PPD may also cause damage to the lungs.…”

Section: Introductionmentioning

confidence: 99%

“…In order to evaluate skin discomfort and correlate it with the effects on the individual, there is also a need for methods to determine the clinical severity of people. Compared with patch-test to PPD allergy in previous research, the Visual analogue scale (VAS) could evaluate the skin discomfort without an obvious allergic reaction 8 , 17 . Whether these adverse effects (pulmonary dysfunction and pruritus) of PPD lead to a decline in their life quality, and then interfere with their activities of daily living and work is noteworthy.…”

Section: Introductionmentioning

confidence: 99%

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Association of p-phenylenediamine exposure with alterations of pulmonary function, pruritus and health-related quality of life in hair dye factory workers: a cross-sectional study

Zhang¹,

Zhang

Zeng

et al. 2023

Sci Rep

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P-Phenylenediamine (PPD) is a common component of hair dye, which can cause skin contact allergy and asthma with impaired pulmonary function. However, the adverse effects of occupational exposure to different dose PPD was rarely mentioned. We recruited 124 workers from a hair dye factory to explore the association of occupational PPD exposure on pulmonary function, pruritus and health related quality of life (HRQL). We categorized exposure to PPD into 3 levels: lower exposure group (< 0.00001 mg/m3); middle exposure group (0.00001–0.00033 mg/m3); higher exposure group (0.00033–0.047 mg/m3). The HRQL and subjective pruritus of the workers were assessed by the short form 36 health survey (SF-36) and Visual analogue scale (VAS) of pruritus, respectively. In the high PPD-exposed group, the percentage of FEV1 (FEV1%) was lower in higher exposure group compared with lower exposure group. The FEV1/FVC was also lower in comparison to the higher exposure and middle exposure groups (p < 0.05). PPD levels were negatively correlated with vitality and mental health (p < 0.01). The structural equation model showed the positive effects of PPD on VAS level (β = 0.213, p < 0.001), and indicated partly negtive effects of PPD on total score of SF-36 (β = − 0.465, p = 0.002), respectively. Our results indicate that occupational exposure to PPD might be associated with pulmonary function impairment, poor HRQL, and subjective pruritus of the workers.

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Both Prevalence and Severity of Pruritus are Associated with Age in Chinese Patients with Skin Diseases

Cited by 9 publications

References 26 publications

Amplification genetic engineering strategy by Crispr-Cas13 Enzymes for detection and treatment COVID-19 mediated with gold nanoparticle (AUNP)

Amplification genetic engineering strategy by Crispr-Cas13 Enzymes for detection and treatment COVID-19 mediated with gold nanoparticle (AUNP)

Pruritus dan modalitas terapi terkini: Sebuah tinjauan pustaka

Association of p-phenylenediamine exposure with alterations of pulmonary function, pruritus and health-related quality of life in hair dye factory workers: a cross-sectional study

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