Globe artichoke (Cynara scolymus L.) is an herbaceous, edible plant and is cultivated for its immature head (bud) part. In 2016 and 2017, significant damages due to rots on the heads of globe artichoke plants were observed in the farmer fields in the Western Mediterranean Region of Turkey. To determine the cause of the rots, samples were taken from necrotic tissues. Fungal isolates were obtained by the agar-plate method and examined in detail. Based on the morphological and ITS region of the rDNA of the isolates, the causal agent of the disease was determined as Botrytis cinerea Pers. that was previously reported in the USA and Argentina. To our knowledge, this is the first publication that reports the occurrence and prevalence of B. cinerea that causes head rots and economic losses in globe artichoke production in the Western Mediterranean Region of Turkey. Although B. cinerea is a common plant pathogenic fungus with a wide range of hosts and little is known Botrytis rot of globe artichoke in Turkey. With this study, the causal agent of the disease was identified, and the status of the disease in globe artichoke growing areas and the influence of the disease on the production were investigated. Surveys were conducted in seven locations (Muratpaşa, Kepez, Aksu, Serik, Manavgat, Gazipaşa, and Kumluca) in the Western Mediterranean Region in 2016 and 2017. A simple random sampling method was used in the surveys and a total of 95 samples were selected from 79 fields in both years.Mean disease incidence and prevalence were 14.7 and 37.0% in 2016, and while they were 17.5 and 51.1% in 2017, respectively. This study revealed that B. cinerea has a significant impact on globe artichoke production by inducing head rots and accordingly 16.1% annual yield loss in pre-harvest period.