Bottom–up nanoparticle synthesis: a review of techniques, polyphenol-based core materials, and their properties

Pomegranate seed polyphenol-based nanosheets as an efficient inhibitor of amyloid fibril assembly and cytotoxicity of HEWL

“…While there are many reports describing the effects of polyphenol-based nanoparticles on assembly process of various peptides and proteins, 9,11,54,55 we believe that our work has characteristics that distinguish it from the others. First, to avoid the profound challenges introduced by foreign additives including metals and polymers (commonly used as core materials for preparation of polyphenolic nanoparticles), [56][57][58][59] we employed direct pyrolysis to self-polymerize PFPS. Second, the PFPS nanosheets are water-soluble nano-sized particles (without limitations such as poor water solubility and low bioavailability that greatly restrict therapeutic application of natural polyphenols), and compared to the bulk form, show considerable capacity to prevent assembly process of HEWL, as at PFPS nanosheets:HEWL molar ratios of as low as 1 : 33 the bril formation process was completely inhibited.…”

Retrospective analysis of the key molecules involved in the green synthesis of nanoparticles

“…92 Furthermore, nanotechnology can protect polyphenols’ stability, efficiency, and bioavailability from the effects of temperature and pH. 93 The metal–polyphenol network generated by the coordination interaction of polyphenols with metal ions is known to have a variety of biological functions, including antioxidant, anticancer, and antibacterial activities. 92,94,95…”

“…92 Furthermore, nanotechnology can protect polyphenols' stability, efficiency, and bioavailability from the effects of temperature and pH. 93 The metal-polyphenol network generated by the coordination interaction of polyphenols with metal ions is known to have a variety of biological functions, including antioxidant, anticancer, and antibacterial activities. 92,94,95 Rattanata et al 96 synthesized spherical AuNPs using gallic acid, one of the naturally occurring polyphenols, and these NPs showed antibacterial activity against Plesiomonas shigelloides and Shigella flexneri B. NPs such as AgNPs and SeNPs synthesized using gallic acid also had a spherical form and showed high antibacterial action against E. coli and B. subtilis.…”

Green synthesis of ZrO2 nanoparticles and nanocomposites for biomedical and environmental applications: a review

“…This means that it needs the participation of enormous mechanical energy sources such as milling, and ionic sputtering (Shrimal et al 2020 ). As a result, top-down strategy brings many inevitable drawbacks of causing secondary impressions or intermediates, altering the physicochemical property and surface chemistry of as-synthesized nanoparticles (Indiarto et al 2021 ). More importantly, nano-sized particles are mostly unattainable by top-down approach.…”