Bottom-up synthesis of carbon nanoparticles with higher doxorubicin efficacy

Bayda, Samer; Hadla, Mohamad; Palazzolo, Stefano; Kumar, Vinit; Caligiuri, Isabella; Ambrosi, Emmanuele; Pontoglio, Enrico; Agostini, Marco; Tuccinardi, Tiziano; Benedetti, Alvise; Riello, Pietro; Canzonieri, Vincenzo; Corona, Giuseppe; Toffoli, Giuseppe; Rizzolio, Flavio

doi:10.1016/j.jconrel.2017.01.022

Cited by 59 publications

(50 citation statements)

References 81 publications

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“…The mean body weight ( Figure 6B) and blood cells (Figure 6C) of the HCS-injected Balb/c mice were similar to those of the control mice (Balb/c mice without HCS administration). This result was in accordance with the results reported by Bayda et al 37 …”

Section: Ex Vivo and In Vivo Toxicity Assayssupporting

confidence: 94%

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Delivery of a chemotherapeutic drug using novel hollow carbon spheres for esophageal cancer treatment

Zhang¹,

Yao²,

Wei³

et al. 2017

IJN

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Low toxicity and high efficacy are the key factors influencing the real-world clinical applications of nanomaterial-assisted drug delivery. In this study, novel hollow carbon spheres (HCSs) with narrow size distribution were developed. In addition to demonstrating their ease of synthesis for large-scale production, we also demonstrated in vitro that the HCSs possessed high drug-loading capacity, lower cell toxicity, and optimal drug release profile at low pH, similar to the pH in the tumor microenvironment. The HCSs also displayed excellent immunocompatibility and could rapidly distribute themselves in the cytoplasm to escape lysosomal clearance. More importantly, the HCSs could efficiently deliver doxorubicin (a representative chemotherapeutic drug) to tumor sites, which resulted in significant inhibition of tumor growth in an esophageal xenograft cancer model. This also prolonged the circulation time and altered the biodistribution of the drug. In conclusion, this study revealed a novel drug delivery system for targeted tumor therapy.

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Section: Ex Vivo and In Vivo Toxicity Assayssupporting

confidence: 94%

“…The results revealed that Dox release was comparatively slower at alkaline pH (pH 7.4) as shown in Figure 7C (*p,0.05; **p,0.01). This observation was consistent with the observations reported by Bayda et al 37 and Qiu et al 42 Dox is a weak amphipathic base. The protonated form of Dox is ~10-fold that of free base.…”

supporting

confidence: 93%

Delivery of a chemotherapeutic drug using novel hollow carbon spheres for esophageal cancer treatment

Zhang¹,

Yao²,

Wei³

et al. 2017

IJN

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“…Organoids were phenotypically characterized by histological and immunohistochemical (IHC) staining for the most common liver markers ( Figure 2). In accordance with cyto-morphological evidence reported in the literature [19], microscopic examination of haematoxylin and eosin (H&E) staining showed that liver organoids had the typical features of hepatic progenitors and mature hepatocytes. Liver organoids retained their stemness and proliferative potential, confirmed respectively by the strong immunopositivity for CD133 and octamer-binding transcription factor 4 (OCT4) stem cell markers and Ki67 proliferation marker.…”

Section: Liver Organoid Toxicitysupporting

confidence: 86%

An Effective Multi-Stage Liposomal DNA Origami Nanosystem for In Vivo Cancer Therapy

Palazzolo

Hadla

Spena

et al. 2019

Cancers

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DNA origami systems could be important candidates for clinical applications. Unfortunately, their intrinsic properties such as the activation of non-specific immune system responses leading to inflammation, instability in physiological solutions, and a short in vivo lifetime are the major challenges for real world applications. A compact short tube DNA origami (STDO) of 30 nm in length and 10 nm in width was designed to fit inside the core of a stealth liposome (LSTDO) of about 150 nm to remote load doxorubicin. Biocompatibility was tested in three-dimensional (3D) organoid cultures and in vivo. Efficacy was evaluated in different cell lines and in a xenograft breast cancer mouse model. As described in a previous work, LSTDO is highly stable and biocompatible, escaping the recognition of the immune system. Here we show that LSTDO have an increased toleration in mouse liver organoids used as an ex vivo model that recapitulate the tissue of origin. This innovative drug delivery system (DDS) improves the antitumoral efficacy and biodistribution of doxorubicin in tumor-bearing mice and decreases bone marrow toxicity. Our application is an attractive system for the remote loading of other drugs able to interact with DNA for the preparation of liposomal formulations.

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“…DOX can also directly loaded on the surface of CDs for localized cancer therapy by simply mixing these CDs and DOX [127,128]. DOX can be released in the tumor acid microenvironment [129,130]. Chemotherapeutic DNA-modifying cisplatin and topoisomerase II-inhibiting DOX were conjugated on the full-color emissive CDs via a pH sensitive hydrazone bond [131].…”

Section: Fluorescent Cds Conjugated With Chemical Therapeutic Agentsmentioning

confidence: 99%

Recent advance of carbon dots in bio-related applications

Wang

Bao

et al. 2020

J. Phys. Mater.

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Carbon dots (CDs) is a kind of carbon nanoparticles with a plentiful of surface functional groups and tunable emission with different excitation wavelength. Broadly speaking, CDs include carbon nanodots, carbon quantum dots, graphene quantum dots, carbonized polymer dots. Due to the unique nature, they are explored for various applications in the bio-related fields such as bioimaging, sensor for ion and (bio)molecules, catalyst, LED and other fields. They are viewed as great alternative tracers to the current fluorescent biomarkers in personalized nanomedicine and surgery operation monitoring. In this review, we summarized the recent progress in the development of CDs, including improvement in fluorescence properties, two-photon fluorescence, and integration with other modalities as theragnostic agents. Specifically, we discussed the preparation of dual-modal imaging agents to improve the accuracy of diagnosis, the combination of imaging and targeting functionality for the effective accumulation of biomarkers, and the integration of imaging and therapeutic agents to effectively monitor the localization and concentration of therapeutic agents. Finally, the theragnostic agents composed of three functionalities (e.g. targeting, imaging, and therapy) were summarized to provide readers with future perspectives in this field.

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Bottom-up synthesis of carbon nanoparticles with higher doxorubicin efficacy

Cited by 59 publications

References 81 publications

Delivery of a chemotherapeutic drug using novel hollow carbon spheres for esophageal cancer treatment

Delivery of a chemotherapeutic drug using novel hollow carbon spheres for esophageal cancer treatment

An Effective Multi-Stage Liposomal DNA Origami Nanosystem for In Vivo Cancer Therapy

Recent advance of carbon dots in bio-related applications

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