Botulinum Neurotoxin A Decreases Infiltrating Cutaneous Lymphocytes and Improves Acanthosis in the KC-Tie2 Mouse Model

Ward, Nicole L.; Kavlick, Kevin D.; Diaconu, Doina; Dawes, Sean M.; Michaels, Kellie A.; Gilbert, Erin W.

doi:10.1038/jid.2012.60

Cited by 44 publications

(50 citation statements)

References 16 publications

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“…Therefore, the clinical observation that psoriasis undergoes remission following loss of innervation, nerve function or nervous system injury, supports this hypothesis [69] . BoNT-A inhibits nerve-derived release of CGRP and SP, and this probably explains the subjective clinical observation of disease improvement in inverse psoriasis following BoNT-A administration by Zanchi et al [70] .…”

Section: Psoriasissupporting

confidence: 53%

“…BoNT-A inhibits nerve-derived release of CGRP and SP, and this probably explains the subjective clinical observation of disease improvement in inverse psoriasis following BoNT-A administration by Zanchi et al [70] . Ward et al [69] demonstrated, using adult KC-Tie2 mouse (a murine model of psoriasiform dermatitis) that the intradermal injections of BoNT-A lead to a significant improvement versus placebo in acanthosis and a reduction of cutaneous lymphocyte infiltration. However, clinical reports and observational study published are few and not placebo-controlled.…”

Section: Psoriasismentioning

confidence: 99%

See 1 more Smart Citation

Botulinum Toxin Off-Label Use in Dermatology: A Review

Campanati

Martina

Giuliodori

et al. 2017

Skin Appendage Disord

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focal hyperhidrosis, aesthetic medicine and neurological conditions with a strong efficacy and safety profile [1][2][3][4][5][6][7] . The enormous therapeutic potential of this drug contributed to a number of broad applications, especially in dermatological diseases. A large number of these indications are still lacking shared, approved protocols for dilution, doses, and timing of follow-up and retreatment. Also the injection techniques are still debated, depending on the operator's experience, angle of injection and depth. We have previously published a novel injection approach consisting in a needle adaptor that ensures a uniform administration of the toxin [3] . The aim of this review was to collect and analyze the published data concerning the most relevant off-label indications of BoNT-A. MethodsA PubMed search from 1950 to July 2016 was performed to identify any reports on the use of botulinum toxin in off-label indications concerning dermatology. We detected these articles using the terms "botulinum toxin dermatology," "botulinum toxin treatment," "botulinum toxin off-label," and meshed with a secondary search of studies pertaining to each indication. Only studies in English were reviewed. All studies that met the criteria were included and summarized in this review. KeywordsBotulinum toxin · Off-label therapy · Keloids · Hidradenitis suppurativa · Folds dermatitis Abstract Background: Botulinum toxin is a neurotoxin produced by the bacterium Clostridium botulinum which causes a flaccid muscle paralysis. It is currently used for aesthetic treatments and in the focal hyperhidrosis. Recently, botulinum toxin has also been used experimentally in many other dermatological conditions with good results. Objective: To review and analyze the possible botulinum toxin off-label applications published. Methods: A retrospective review of the published data was conducted. Conclusions: this potent drug can lead to several off-label indications of interest for dermatologists. Further clinical trials are still needed to better understand the real efficacy and safety of these applications and to standardize injection and dose protocols.

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Section: Psoriasissupporting

confidence: 53%

Section: Psoriasismentioning

confidence: 99%

Botulinum Toxin Off-Label Use in Dermatology: A Review

Campanati

Martina

Giuliodori

et al. 2017

Skin Appendage Disord

View full text Add to dashboard Cite

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“…Alternatively, cutaneous nerves are known to secrete cytokines such as Calcitonin gene-related peptide as well as Substance P, which can serve functional roles during epidermal development and pathology (Lumpkin et al, 2010). Indeed, neural changes are often observed in patients with psoriasis and atopic eczema, and nerve removal inhibits the epidermal hyperplasia observed in experimental models of these diseases (Ostrowski et al, 2011; Ward et al, 2012). …”

Section: Discussionmentioning

confidence: 99%

Basal Cell Carcinoma Preferentially Arises from Stem Cells within Hair Follicle and Mechanosensory Niches

et al. 2015

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SUMMARY Basal cell carcinoma (BCC) is characterized by frequent loss of PTCH1, leading to constitutive activation of the Hedgehog pathway. Although the requirement for Hedgehog in BCC is well-established, the identity of disease-initiating cells and the compartments in which they reside remain controversial. By using several inducible Cre drivers to delete Ptch1 in different cell compartments in mice, we show here that multiple hair follicle stem cell populations readily develop BCC-like tumors. In contrast, stem cells within the interfollicular epidermis do not efficiently form tumors. Notably, we observed that innervated Gli1-expressing progenitors within mechanosensory touch dome epithelia are highly tumorigenic. Sensory nerves activate Hedgehog signaling in normal touch domes, while denervation attenuates touch dome-derived tumors. Together, our studies identify varying tumor susceptibilities among different stem cell populations in the skin, highlight touch dome epithelia as “hot spots” for tumor formation, and implicate cutaneous nerves as mediators of tumorigenesis.

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“…In addition to Na V 1.8 + , TRPA1 was identified as a key molecule in immune cell – chemosensory neuron interactions in the airways, driving asthmatic airway inflammation in the murine ovalbumin model of asthma (Caceres et al, 2009). Neuro-immune communication and a specific role for TRPA1 and cutaneous sensory nerve release of CGRP and SP have been implicated in exacerbating inflammation in dermatitis (Liu et al, 2013; Ward et al, 2012). …”

Section: Reflexes In Neuro-immune Communicationmentioning

confidence: 99%

Mechanisms and Therapeutic Relevance of Neuro-immune Communication

2017

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Active research at the frontiers of immunology and neuroscience has identified multiple points of interaction and communication between the immune system and the nervous system. Immune cell activation stimulates neuronal circuits that regulate innate and adaptive immunity. Molecular mechanistic insights into the inflammatory reflex and other neuro-immune interactions have greatly advanced understanding immunity, and identified new therapeutic possibilities in inflammatory and autoimmune diseases. Recent successful clinical trials using bioelectronic devices that modulate the inflammatory reflex to significantly ameliorate rheumatoid arthritis and inflammatory bowel disease provide a path for using electrons as a therapeutic modality to target molecular mechanisms of immunity. Here we review mechanisms of peripheral sensory neuronal function modulation in response to immune challenges and neural regulation of immunity and inflammation, and discuss the therapeutic implications of this mechanistic insight.

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Botulinum Neurotoxin A Decreases Infiltrating Cutaneous Lymphocytes and Improves Acanthosis in the KC-Tie2 Mouse Model

Cited by 44 publications

References 16 publications

Botulinum Toxin Off-Label Use in Dermatology: A Review

Botulinum Toxin Off-Label Use in Dermatology: A Review

Basal Cell Carcinoma Preferentially Arises from Stem Cells within Hair Follicle and Mechanosensory Niches

Mechanisms and Therapeutic Relevance of Neuro-immune Communication

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