Botulinum toxin treatment in upper limb spasticity: Treatment consistency

Papavasiliou, Antigone; Nikaina, Irene; Bouros, Panagiotis; Rizou, Ioanna; Filiopoulos, Constantine

doi:10.1016/j.ejpn.2011.07.013

Cited by 9 publications

(16 citation statements)

References 42 publications

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“…Taking this suggestion into account, the participants in the studies reviewed were advantageous in terms of age. The only study in this review to evaluate which age group was more advantageous for BoNT‐A was by Papavasiliou et al We are therefore unable to generalize that repeat BoNT‐A treatment could be more beneficial for younger children with CP.…”

Section: Discussionmentioning

confidence: 88%

“…The sample size was not justified and co‐intervention was not avoided in a few of the articles. Most of the studies included in this review did not provide information about contamination …”

Section: Resultsmentioning

confidence: 99%

“…The majority of the studies used the Modified Ashworth scale to assess spasticity . Only Olesch et al and Papavasiliou et al used the Tardieu scale or the Modified Tardieu scale.…”

Section: Resultsmentioning

confidence: 99%

“…Papavasiliou et al and Valevski et al did not evaluate ROM in long term, but reported important improvements in the short term (1mo after the injection). Linder et al found ROM to increase 1 month after the first injection but to regress to the initial value in 12 months.…”

Section: Resultsmentioning

confidence: 99%

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Should botulinum toxin A injections be repeated in children with cerebral palsy? A systematic review

Kahraman

Seyhan

Değer

et al. 2016

Develop Med Child Neuro

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ICFInternational Classification of Function, Disability and Health ICF-CY International Classification of Function, Disability and Health -Children and Youth Version ROM Range of motion AIM The aim of this study was to determine the effects of repeat botulinum toxin A (BoNT-A)injections in children with spastic cerebral palsy (CP) on the basis of a best evidence synthesis.METHOD This study included 13 original articles after searching the literature to retrieve information. We used the critical review form produced by McMaster University to determine the methodological quality of the studies, and then confirmed the levels of evidence from Sackett. The studies were also evaluated using the International Classification of Function, Disability and Health -Children and Youth Version (ICF-CY).RESULTS A total of 893 children with spastic CP who had been administered repeat BoNT-A injections were evaluated. The evidence level was II in four of the thirteen studies, III in four studies, and IV in five studies. The McMaster review form score was 14 in two studies, 13 in four studies, and 12 in seven studies. The results showed that repeat BoNT-A may be a safe and an effective approach. The first two injections/one repeat especially relieve spasticity and improve fine and gross motor activities.INTERPRETATION Future studies to investigate the effectiveness of repeat BoNT-A in children with spastic CP may be planned within the framework of the ICF-CY to include well-designed randomized controlled trials and those conducted on larger homogenous groups.Cerebral palsy (CP) is a neuromuscular pathology that is caused by an injury to the immature brain, and that limits activity by affecting the development of body function and posture. 1,2 CP is the most common childhood disability, and about 70% to 80% is of the spastic type.

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Section: Discussionmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 99%

“…The majority of the studies used the Modified Ashworth scale to assess spasticity . Only Olesch et al and Papavasiliou et al used the Tardieu scale or the Modified Tardieu scale.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Should botulinum toxin A injections be repeated in children with cerebral palsy? A systematic review

Kahraman

Seyhan

Değer

et al. 2016

Develop Med Child Neuro

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“…В 2012 г. были представлены результаты [20] применения диспорта для лечения спастичности верхних конечностей у пациентов с ДЦП с проведе-нием повторных инъекций. Средняя общая доза со-ставила 7,3 Ед/кг массы тела, при этом максималь-ная общая доза диспорта достигала до 34,7 Ед/кг массы тела.…”

Section: Discussionunclassified

Selection of a dose of the botulinum toxin A in spastic forms of cerebral palsy

Куренков

Клочкова

Каримова

et al. 2015

Z. nevrol. psikhiatr. im. S.S. Korsakova

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A consensus statement on the use of botulinum toxin in pediatric patients

Vova

Green

Brandenburg

et al. 2021

PM&R

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Botulinum toxin has been used in medicine for the past 30 years. However, there continues to be controversy about the appropriate uses and dosing, especially in the pediatric population. A panel of nine pediatric physiatrists from different regions and previous training programs in the United States were nominated based on institutional reputation and botulinum toxin (BoNT) experience. Based on a review of the current literature, the goal was to provide the rationale for recommendations on the administration of BoNT in the pediatric population. The goal was not only to review safety, dosing, and injection techniques but also to develop a consensus on the appropriate uses in the pediatric population. In addition to upper and lower limb spasticity, the consensus also provides recommendations for congenital muscular torticollis, cervical dystonia, sialorrhea, and brachial plexus palsies.

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Botulinum toxin treatment in upper limb spasticity: Treatment consistency

Cited by 9 publications

References 42 publications

Should botulinum toxin A injections be repeated in children with cerebral palsy? A systematic review

Should botulinum toxin A injections be repeated in children with cerebral palsy? A systematic review

Selection of a dose of the botulinum toxin A in spastic forms of cerebral palsy

A consensus statement on the use of botulinum toxin in pediatric patients

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