Negativity is an entanglement monotone frequently used to quantify entanglement in bipartite states. Because negativity is a non-analytic function of a density matrix, existing methods used in the physics literature are insufficient to compute its derivatives. To this end we develop techniques in the calculus of complex, patterned matrices and use them to conduct a perturbative analysis of negativity in terms of arbitrary variations of the density operator. The result is an easy-to-implement expansion that can be carried out to all orders. On the way we provide convenient representations of the partial transposition map appearing in the definition of negativity. Our methods are well-suited to study the growth and decay of entanglement in a wide range of physical systems, including the generic linear growth of entanglement in many-body systems, and have broad relevance to many functions of quantum states and observables.1 By most definitions, entanglement measures ought to reduce to the entanglement entropy [17,24] in the pure state case; negativity does not. Nevertheless, we alternate between calling it a monotone and measure depending on the subsystem dimensions.arXiv:1809.07772v2 [quant-ph]