Boundary-enhancement in propagation-based x-ray phase-contrast tomosynthesis improves depth position characterization

Guan, Huifeng; Xu, Qiaofeng; Garson, A.; Anastasio, Mark A.

doi:10.1088/0031-9155/60/8/n151

Cited by 7 publications

(6 citation statements)

References 46 publications

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“…Specifically, optimized data-acquisition strategies need to be coupled with advanced image reconstruction algorithms in order to overcome the long data-acquisition times and relatively high radiation doses currently required for small animal imaging. Recent results in these areas provide enthusiasm for this possibility 19, 20 .…”

Section: Discussionmentioning

confidence: 99%

X-ray Phase Contrast Allows Three Dimensional, Quantitative Imaging of Hydrogel Implants

et al. 2015

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Three dimensional imaging techniques are needed for the evaluation and assessment of biomaterials used for tissue engineering and drug delivery applications. Hydrogels are a particularly popular class of materials for medical applications but are difficult to image in tissue using most available imaging modalities. Imaging techniques based on X-ray Phase Contrast (XPC) have shown promise for tissue engineering applications due to their ability to provide image contrast based on multiple X-ray properties. In this manuscript, we investigate the use of XPC for imaging a model hydrogel and soft tissue structure. Porous fibrin loaded poly(ethylene glycol) hydrogels were synthesized and implanted in a rodent subcutaneous model. Samples were explanted and imaged with an analyzer-based XPC technique and processed and stained for histology for comparison. Both hydrogel and soft tissues structures could be identified in XPC images. Structure in skeletal muscle adjacent could be visualized and invading fibrovascular tissue could be quantified. There were no differences between invading tissue measurements from XPC and the gold-standard histology. These results provide evidence of the significant potential of techniques based on XPC for 3D imaging of hydrogel structure and local tissue response.

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Section: Discussionmentioning

confidence: 99%

X-ray Phase Contrast Allows Three Dimensional, Quantitative Imaging of Hydrogel Implants

et al. 2015

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“…The flexibility with regard to the measurement geometry and ability to mitigate data incompleteness makes iterative reconstruction algorithms more suited to the tomosynthesis problem. 51 …”

Section: Xpc Imagingmentioning

confidence: 99%

Imaging of Hydrogel Microsphere Structure and Foreign Body Response Based on Endogenous X-Ray Phase Contrast

Appel

Ibarra

Somo

et al. 2016

Tissue Engineering Part C: Methods

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Transplantation of functional islets encapsulated in stable biomaterials has the potential to cure Type I diabetes. However, the success of these materials requires the ability to quantitatively evaluate their stability. Imaging techniques that enable monitoring of biomaterial performance are critical to further development in the field. Xray phase-contrast (XPC) imaging is an emerging class of X-ray techniques that have shown significant promise for imaging biomaterial and soft tissue structures. In this study, XPC imaging techniques are shown to enable three dimensional (3D) imaging and evaluation of islet volume, alginate hydrogel structure, and local soft tissue features ex vivo. Rat islets were encapsulated in sterile ultrapurified alginate systems produced using a highthroughput microfluidic system. The encapsulated islets were implanted in omentum pouches created in a rodent model of type 1 diabetes. Microbeads were imaged with XPC imaging before implantation and as whole tissue samples after explantation from the animals. XPC microcomputed tomography (mCT) was performed with systems using tube-based and synchrotron X-ray sources. Islets could be identified within alginate beads and the islet volume was quantified in the synchrotron-based mCT volumes. Omental adipose tissue could be distinguished from inflammatory regions resulting from implanted beads in harvested samples with both XPC imaging techniques. Individual beads and the local encapsulation response were observed and quantified using quantitative measurements, which showed good agreement with histology. The 3D structure of the microbeads could be characterized with XPC imaging and failed beads could also be identified. These results point to the substantial potential of XPC imaging as a tool for imaging biomaterials in small animal models and deliver a critical step toward in vivo imaging.

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“…Nevertheless, the technological developments have encouraged the design of new inline PCI set-ups which have permitted to extend the range of applications towards higher x-ray energies [25–27]. Numerous studies have implemented the in-line phase contrast tomosynthesis with micro-focus x-ray sources in preclinical studies with breast tissue samples, fish bone, mouse and rabbit lungs [28–30]. …”

Section: Introductionmentioning

confidence: 99%

Characterization of continuous and pulsed emission modes of a hybrid micro focus x-ray source for medical imaging applications

Ghani

Wong

Ren

et al. 2017

Nuclear Instruments and Methods in Physics Research Section A:

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The aim of this study was to quantitatively characterize a micro focus x-ray tube that can operate in both continuous and pulsed emission modes. The micro focus x-ray source (Model L9181-06, Hamamatsu Photonics, Japan) has a varying focal spot size ranging from 16–50 μm as the source output power changes from 10–39 W. We measured the source output, beam quality, focal spot sizes, kV accuracy, spectra shapes and spatial resolution. Source output was measured using an ionization chamber for various tube voltages (kVs) with varying current (μA) and distances. The beam quality was measured in terms of half value layer (HVL), kV accuracy was measured with a non-invasive kV meter, and the spectra was measured using a compact integrated spectrometer system. The focal spot sizes were measured using a slit method with a CCD detector with a pixel pitch of 22 μm. The spatial resolution was quantitatively measured using the slit method with a CMOS flat panel detector with a 50 μm pixel pitch, and compared to the qualitative results obtained by imaging a contrast bar pattern. The focal spot sizes in the vertical direction were smaller than that of the horizontal direction, the impact of which was visible when comparing the spatial resolution values. Our analyses revealed that both emission modes yield comparable imaging performances in terms of beam quality, spectra shape and spatial resolution effects. There were no significantly large differences, thus providing the motivation for future studies to design and develop stable and robust cone beam imaging systems for various diagnostic applications.

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Boundary-enhancement in propagation-based x-ray phase-contrast tomosynthesis improves depth position characterization

Cited by 7 publications

References 46 publications

X-ray Phase Contrast Allows Three Dimensional, Quantitative Imaging of Hydrogel Implants

X-ray Phase Contrast Allows Three Dimensional, Quantitative Imaging of Hydrogel Implants

Imaging of Hydrogel Microsphere Structure and Foreign Body Response Based on Endogenous X-Ray Phase Contrast

Characterization of continuous and pulsed emission modes of a hybrid micro focus x-ray source for medical imaging applications

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