The study of shape effects in nanofluids plays a vital role in the fluid flow as well as heat propagation. Hence, the different shape factors of molybdenum disulfide MoS2 on a stretchable disc with rotation under the effect of the magnetic field, chemical response, and activation energy are examined. The set of partial differential equations is converted into ordinary differential equations (ODEs) by using von Karman's transformations, and the obtained ODEs are solved by using Runge‐Kutta‐Fehlberg 45 and shooting techniques. The numerical computations are made by utilizing well‐known maple 17 software. The different physical parameter effects on velocity, temperature, and concentration curves, as well as skin friction and Sherwood numbers, are analyzed through graphs. It is noted that the larger values of solid volume fraction enhances the drag coefficient and reduces the rate of heat transfer. It is further observed that the curve of a viscous fluid is always lesser than curve of a nanofluid.