Abstract. In the paper we find the leading term of the asymptotics at infinity for some fundamental system of solutions to a class of linear differential equations of arbitrary order = , where is a fixed complex number. At that we consider a special class of ShinZettl type and is a quasi-differential expression generated by the matrix in this class. The conditions we assume for the primitives of the coefficients of the quasi-differential expression , that is, for the entries of the corresponding matrix, are not related with their smoothness but just ensures a certain power growth of these primitives at infinity. Thus, the coefficients of the expression can also oscillate. In particular, this includes a wide class of differential equations of arbitrary even or odd order with distribution coefficients of finite order. Employing the known definition of two quasi-differential expressions with nonsmooth coefficients, in the work we propose a method for obtaining asymptotic formulae for the fundamental system of solutions to the considered equation in the case when the left hand side of this equations is represented as a product of two quasi-differential expressions.The obtained results are applied for the spectral analysis of the corresponding singular differential operators. In particular, assuming that the quasi-differential expression is symmetric, by the known scheme we define the minimal closed symmetric operator generated by this expression in the space of Lebesgue square-integrable on [1, +∞) functions (in the Hilbert space ℒ 2 [1, +∞)) and we calculate the deficiency indices for this operator.Keywords: Quasi-derivative, quasi-differential expression, the main term of asymptotic of the fundamental system of solutions, minimal closed symmetric differential operator, deficiency numbers.