In this note, we define p‐adic mixed Lebesgue space and mixed λ‐central Morrey‐type spaces and characterize p‐adic mixed λ‐central bounded mean oscillation space via the boundedness of commutators of p‐adic Hardy‐type operators on p‐adic mixed Lebesgue space. Moreover, we also furnish boundedness of commutators of p‐adic Hardy‐type operators generated with p‐adic mixed λ‐central bounded mean oscillation on mixed λ‐central Morrey space.