Bovine abortion associated with <i>Bacillus licheniformis</i>

Mitchell, Gabriel; Barton, MG

doi:10.1111/j.1751-0813.1986.tb02957.x

Cited by 10 publications

(9 citation statements)

References 6 publications

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“…Pathogenesis is unclear but despite the fact that B. licheniformis cannot, as yet, be confirmed as the primary aetiological agent, its association with distinct placental and fetal lesions is highly suggestive of such a role (Mitchell and Barton, 1986).…”

Section: Veterinary Infectionsmentioning

confidence: 99%

Bacillus species of medical and veterinary importance

Logan

1988

Journal of Medical Microbiology

100

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Section: Veterinary Infectionsmentioning

confidence: 99%

Bacillus species of medical and veterinary importance

Logan

1988

Journal of Medical Microbiology

100

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“…Whilst opportunistic infections with B. lichenlformis are rare in man, bovine infections are fairly common (2,8,9). Most bovine infections have been reported in pregnant cows developing placentitis with subsequent abortion (2,7,10,12). The pathogenesis of the bovine placental infections has not been established.…”

mentioning

confidence: 99%

A preliminary study on the pathogenicity of Bacillus licheniformis bacteria in immunodepressed mice

Agerholm¹,

Jensen²,

Giese³

et al. 1997

APMIS

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preliminary study on the pathogenicity of Bucillus licheniformis bacteria in immunodepressed mice. APMIS 105: [48][49][50][51][52][53][54] 1997.The pathogenicity of 13 strains of Bacillus licheniformis was studied in immunodepressed mice. The strains had been isolated from cases of bovine abortions (n=5), bovine feedstuffs (n=3), soil (n= l), and grain products (n=2). The origin of two strains was unknown. Groups of 10 mice were inoculated intravenously with B. licheniformis bacteria at doses from < lo6 to 10" colony-forming units. Following 7 days of infection, the animals were euthanized and examined bacteriologically, histologically, and immunohistochemically using a PAP technique based on primary polyclonal rabbit anti-B. licheniformis antibodies. B. lichen[formis bacteria were reisolated from the liver, spleen, or kidneys of mice in all groups. Inflammatory lesions were present in mice of all immunodepressed groups, but only brain and pulmonic lesions were definitely attributed to B. licheniformis infection, as strong immunostaining was found within these lesions. It is concluded that all strains of B. licheniformis examined were pathogenic for immunodepressed mice, and that spontaneous infections may be established by bacterial strains to which susceptible individuals are accidentally exposed.

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“…have been reported with incidence of 1-10%, with the highest incidence reported from Europe. 3,4,6,7,12,15 In some studies B. licheniformis has been reported in association with bovine abortion, 3,4,7,13,15,21,24 but in several surveys the species have not been stated.…”

mentioning

confidence: 99%

“…3,4,6,[14][15][16][17][18][19]21,24,25,31 In diagnostic surveys on abortion in cattle, abortions associated with Bacillus spp. have been reported with incidence of 1-10%, with the highest incidence reported from Europe.…”

mentioning

confidence: 99%

Experimental Infection of Pregnant Cows with Bacillus licheniformis Bacteria

Agerholm¹,

Jensen²,

Dantzer³

et al. 1999

Vet Pathol

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Abstract. To study the abortifacient potential and fetoplacental tropism of Bacillus licheniformis bacteria, eight cows in the sixth to eighth month of gestation were inoculated intravenously either once (n ϭ 4) or on four successive days (n ϭ 4) with B. licheniformis at doses ranging from 10 9 to 10 12 colony-forming units. Cows were euthanatized and necropsied prior to abortion (n ϭ 2), at the time of abortion (n ϭ 2), or at calving (n ϭ 4). Live-born calves (n ϭ 5) were euthanatized immediately after delivery and necropsied. B. licheniformis was reisolated from placentomes/endometrium in six of eight (75%) cows and from one fetus aborted 43 days after inoculation. Lesions associated with B. licheniformis were restricted to the pregnant uterus, with the exception of one cow, which developed pneumonia. Necrosis in the fetal compartment of the placenta were present in three of four (75%) cows of both inoculation groups. Lesions were mainly restricted to fetal membranes and especially to the fetal side of the placentomes. Necrosis and diffuse neutrophil infiltrations of both villi and intervillous areas occurred in the fetal part of the placenta, and the placentomal interface was distended by bacteria, neutrophils, erythrocytes, and debris. Within trophoblasts, bacteria were located both free in the cytoplasm and in cytoplasmatic vesicles. Inflammation was present in three of eight (38%) calves. Placental and fetal lesions were similar to those found in cases of spontaneous abortions associated with B. licheniformis. The abortifacient potential of B. licheniformis and the tropism for the bovine placenta is demonstrated here for the first time.

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Bovine abortion associated with Bacillus licheniformis

Cited by 10 publications

References 6 publications

Bacillus species of medical and veterinary importance

Bacillus species of medical and veterinary importance

A preliminary study on the pathogenicity of Bacillus licheniformis bacteria in immunodepressed mice

Experimental Infection of Pregnant Cows with Bacillus licheniformis Bacteria

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