Bovine lactoferrin supplementation for prevention of necrotizing enterocolitis in very-low-birth-weight neonates: a randomized clinical trial

Manzoni, Paolo; Meyer, Michael; Stolfi, Ilaria; Rinaldi, Matteo; Cattani, Silvia; Pugni, Lorenza; Romeo, Mario Giovanni; Messner, Hubert; Decembrino, Lidia; Laforgia, Nicola; Vagnarelli, Federica; Memo, Luigi; Bordignon, Linda; Maule, Milena; Gallo, Eugenia; Mostert, M.; Quercia, Michele; Bollani, Lina; Pedicino, Roberto; Renzullo, Livia; Betta, Pasqua; Ferrari, Fabrizio; Alexander, Tanith; Magaldi, Rosario; Farina, Daniele; Mosca, Fabio; Stronati, Mauro

doi:10.1016/s0378-3782(14)70020-9

Cited by 174 publications

(133 citation statements)

References 13 publications

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“…Among the different strategies employed to reduce the incidence and/or severity of NEC and prevent LOS in preterm infants, the use of human breast milk (HM) and/or supplementation with pro-and/or-prebiotics have rendered effective results (48)(49)(50). In the following paragraphs, we will expand on these strategies.…”

Section: Potential Tools To Modulate Preterm Microbiomementioning

confidence: 99%

Factors influencing gastrointestinal tract and microbiota immune interaction in preterm infants

et al. 2015

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Section: Potential Tools To Modulate Preterm Microbiomementioning

confidence: 99%

Factors influencing gastrointestinal tract and microbiota immune interaction in preterm infants

et al. 2015

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“…Several randomized control trials have reported a reduction in NEC incidence following administration of antenatal glucocorticoids; however the long-term outcomes must still be investigated (31). Lactoferrin has also been shown to reduce inflammatory injury in small studies using animal models (35). Other options include erythropoietin (EPO) and epidermal growth factor (EGF), which are components found in human milk and amniotic fluid that could have protective effects against NEC (36).…”

Section: Other Methods Of Preventionmentioning

confidence: 99%

Necrotizing Enterocolitis: A Narrative Review of Updated Therapeutic and Preventive Interventions

Reid¹,

Thompson-Branch²

2016

J Pediatr Rev

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Context: Necrotizing enterocolitis (NEC) remains one of the most common causes of morbidity and mortality for premature infants in the neonatal intensive care unit (NICU). Many theories concerning its pathophysiology and inciting factors have been suggested but progression in preventing the onset of NEC has been minimal. While this article highlights the pathophysiology, management, and outcomes of NEC, it mainly serves as a narrative review to discuss the emerging methods of treatment and prevention.Evidence Acquisition: A literature search was done using Medline/Pub Med, Cochrane Database of Systematic Reviews via Ovid, and CINAHL Complete with focus on articles published between 2000 and 2016. Searched terms included the following: necrotizing enterocolitis, pathogenesis, prevention, management, breast milk, formula, probiotics, prebiotics, and treatment. Results:Intestinal barrier dysfunction, hypoxic ischemic injury, receipt of packed red blood cells, immature intestinal immunity and alterations of the gut microbiome of the premature infant were reviewed factors that have been studied related to the pathophysiology of NEC. The presentation, staging and management remain relatively unchanged in the last few decades, though there have been a few studies evaluating different surgical options, various antibacterial regimen, and recently use of moderate hypothermia and amniotic fluid stem cells to treat NEC. Use of breast milk, use of pre-, pro-and postbiotics show promise in the prevention of NEC.Conclusions: NEC is a likely multifactorial illness of the gastrointestinal tract affecting mostly premature infants. Recent studies have focused on preventative strategies, with promise in pre-, pro-and postbiotics; however continued research is imperative.

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“…In a recent randomized controlled trial, bovine lactoferrin produced a 65% decrease in any-cause Late-Onset Sep-sis (LOS), and a significant decrease in both surgical and low-stages NEC. (10) As no adverse effects or intolerances to treatment have been reported to date, the role of lactoferrin in the management of infections and NEC in NICU looks very promising and worthy of future, larger-sized trials to confirm these findings.…”

Section: Prevention-current Strategiesmentioning

confidence: 97%

Invasive Candida infections in the nursery: state of the art

Manzoni

Castagnola

Jacqz-Aigrain

et al. 2014

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Bovine lactoferrin supplementation for prevention of necrotizing enterocolitis in very-low-birth-weight neonates: a randomized clinical trial

Cited by 174 publications

References 13 publications

Factors influencing gastrointestinal tract and microbiota immune interaction in preterm infants

Factors influencing gastrointestinal tract and microbiota immune interaction in preterm infants

Necrotizing Enterocolitis: A Narrative Review of Updated Therapeutic and Preventive Interventions

Invasive Candida infections in the nursery: state of the art

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