Bovine serum albumin binding and drug delivery studies with PVA-ferrofluid

Nayar, Suprabha; Mir, Aparna; Ashok, Aarti; Guha, Avijit; Sharma, Vikas

doi:10.1016/s1672-6529(09)60188-8

Cited by 18 publications

(9 citation statements)

References 19 publications

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“…The peak at 3439 cm -1 was the characteristic of stretching vibration of OH. It can be deduced that Fe(OH) 2 , Fe(OH) 3 and FeOOH formed resulting from hydrolyzation on the surface of Fe 3 O 4 . While the peak at 1633 cm -1 also shows existence of Fe-O.…”

Section: Structure Of Crystalmentioning

confidence: 99%

“…The electrons can hop between Fe 2+ and Fe 3+ ions in the octahedral sites at room temperature, rendering magnetite an important part of half-metallic materials. The development of uniform spinel ferrite nanocrystals has been intensively pursued in the applications of ferrofluids [3], catalysis [4], biomedical applications such as magnetic resonance imaging (MRI) [5], drug targeting [6][7] and hyperthermia [8], data storage [9], microwave absorption [10] and magnetorheological fluids [11,12]. Many reports proved that the property of spinel ferrites can be improved by doping metal elements in MFe 2 O 4 owing to their enhanced crystal anisotropy [13].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of M–Nd doped Fe3O4 nanoparticles (M = Co, Ce, Cr, Ni) with tunable magnetic properties

Yousefi¹,

Alimard²

2012

Bull. Chem. Soc. Eth.

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ABSTRACT. Magnetic nanoparticles were prepared by the aqueous co-precipitation method. The magnetic nanoparticles obtained were characterized systematically through the use of an X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDS), scanning electron microscope (SEM), transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR) and a vibrating sampling magnetometer (VSM). The results revealed that the magnetic nanoparticles were spherical shaped with inverse spinel structure. The size of Fe3O4 and Nd-Co doped Fe3O4 magnetic nanoparticles were approximately 15 nm. Magnetic measurement revealed that the nanoparticles were super paramagnetic at room temperature. It was found that the magnetic response of the Fe3O4 increased when it was doped with Nd 3+ and Co 2+ . However, the magnetic response of the Fe3O4 decreased when it was doped with Nd 3+ or Ce 3+ or Cr 3+ or Ni 2+ .

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Section: Structure Of Crystalmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis of M–Nd doped Fe3O4 nanoparticles (M = Co, Ce, Cr, Ni) with tunable magnetic properties

Yousefi¹,

Alimard²

2012

Bull. Chem. Soc. Eth.

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“…It is worth mentioning here that BSA-based nano-biomaterials have been well-studied in the drug delivery field owing to their specificity of being able to get into an infected site. [40] In addition, albumin can easily be taken up by the virus-infected cells since a cytokine storm follows glycocalyx damage in elderly and severely affected COVID-19 patients [28][29][30][31]. In this context, we believed that BSA-coated Zein-NIC NPs would be highly preferred as an ideal injectable formulation for treating COVID-19 patients.…”

Section: Introductionmentioning

confidence: 99%

Bovine Serum Albumin-Coated Niclosamide-Zein Nanoparticles as Potential Injectable Medicine against COVID-19

Choi

Piao

2021

Materials

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(1) Background: COVID-19 has affected millions of people worldwide, but countries with high experimental anti-SARS-CoV-2 vaccination rates among the general population respectively show progress in achieving general herd immunity in the population (a combination of natural and vaccine-induced acquired immunity), resulting in a significant reduction in both newly detected infections and mortality rates. However, the longevity of the vaccines’ ability to provide protection against the ongoing pandemic is still unclear. Therefore, it is of utmost importance to have new medications to fight against the pandemic at the earliest point possible. Recently, it has been found that repurposing already existing drugs could, in fact, be an ideal strategy to formulate effective medication for COVID-19. Though there are many FDA-approved drugs, it has been found that niclosamide (NIC), an anthelmintic drug, has significantly high potential against the SARS-CoV-2 virus. (2) Methods: Here we deployed a simple self-assembling technique through which Zein nanoparticles were successfully used to encapsulate NIC, which was then coated with bovine serum albumin (BSA) in order to improve the drugs’ stability, injectablity, and selectivity towards the virus-infected cells. (3) Results: The particle size for the BSA-stabilized Zein-NIC nanohybrid was found to be less than 200 nm, with excellent colloidal stability and sustained drug release properties. In addition, the nanohybrid showed enhanced drug release behavior under serum conditions, indicating that such a hybrid drug delivery system could be highly beneficial for treating COVID-19 patients suffering from high endothelial glycocalyx damage followed by a cytokine storm related to the severe inflammations.

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“…S3). The outcomes of this binding analysis suggest that the serum proteins could assist the transport of the compounds via blood to the sites of action throughout the body 39 .…”

Section: Resultsmentioning

confidence: 98%

4,5-Disubstituted 1,2,3-triazoles: Effective Inhibition of Indoleamine 2,3-Dioxygenase 1 Enzyme Regulates T cell Activity and Mitigates Tumor Growth

Panda

Pradhan

Chatterjee

et al. 2019

Sci Rep

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The improvement of body’s own immune system is considered one of the safest approaches to fight against cancer and several other diseases. Excessive catabolism of the essential amino acid, L-tryptophan (L-Trp) assists the cancer cells to escape normal immune obliteration. The formation of disproportionate kynurenine and other downstream metabolites suppress the T cell functions. Blocking of this immunosuppressive mechanism is considered as a promising approach against cancer, neurological disorders, autoimmunity, and other immune-mediated diseases. Overexpression of indoleamine 2,3-dioxygenase 1 (IDO1) enzyme is directly related to the induction of immunosuppressive mechanisms and represents an important therapeutic target. Several classes of small molecule-based IDO1 inhibitors have been already reported, but only few compounds are currently being evaluated in various stages of clinical trials as adjuvants or in combination with chemo- and radiotherapies. In the quest for novel structural class(s) of IDO1 inhibitors, we developed a series of 4,5-disubstituted 1,2,3-triazole derivatives. The optimization of 4,5-disubstituted 1,2,3-triazole scaffold and comprehensive biochemical and biophysical studies led to the identification of compounds, 3i, 4i, and 4k as potent and selective inhibitors of IDO1 enzyme with IC50 values at a low nanomolar level. These potent compounds also showed strong IDO1 inhibitory activities in MDA-MB-231 cells with no/negligible level of cytotoxicity. The T cell activity studies revealed that controlled regulation of IDO1 enzyme activity in the presence of these potent compounds could induce immune response against breast cancer cells. The compounds also showed excellent in vivo antitumor efficacy (of tumor growth inhibition = 79–96%) in the female Swiss albino mice. As a consequence, this study describes the first example of 4,5-disubstituted 1,2,3-triazole based IDO1 inhibitors with potential applications for immunotherapeutic studies.

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Bovine serum albumin binding and drug delivery studies with PVA-ferrofluid

Cited by 18 publications

References 19 publications

Synthesis of M–Nd doped Fe<sub>3</sub>O<sub>4</sub> nanoparticles (M = Co, Ce, Cr, Ni) with tunable magnetic properties

Synthesis of M–Nd doped Fe<sub>3</sub>O<sub>4</sub> nanoparticles (M = Co, Ce, Cr, Ni) with tunable magnetic properties

Bovine Serum Albumin-Coated Niclosamide-Zein Nanoparticles as Potential Injectable Medicine against COVID-19

4,5-Disubstituted 1,2,3-triazoles: Effective Inhibition of Indoleamine 2,3-Dioxygenase 1 Enzyme Regulates T cell Activity and Mitigates Tumor Growth

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