Bovine Serum Albumin Coated Upconversion Nanoparticles for Near Infrared Fluorescence Imaging in Mouse Model

Chen, Dan; Zhang, Feng; Lv, Liwei; Han, Zhihao; Wang, Yuheng; Gu, Yueqing; Chen, Haiyan

doi:10.1166/jnn.2017.12625

Cited by 7 publications

(2 citation statements)

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“…8 Therefore, NIR fluorescence imaging possesses great importance in medicinal applications. Considering this, various research groups have developed the NIR- based fluorescence nanoparticles for cancer photodynamic therapy, 9,10 cell labeling, 11 bio-imaging, 12,13 tumor-targeted imaging, 14,15 and biosensing 16 applications. Numerous reports demonstrated the bio-imaging applications of chemically synthesized nanoparticles.…”

Section: ■ Introductionmentioning

confidence: 99%

Biosynthesized Gold Nanoparticles: In Vivo Study of Near-Infrared Fluorescence (NIR)-Based Bio-imaging and Cell Labeling Applications

Kotcherlakota

Nimushakavi

Roy

et al. 2019

ACS Biomater. Sci. Eng.

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Near infrared (NIR) fluorescence imaging is a striking imaging modality for biomedical and clinical applications due to its deep tissue penetration and low phototoxicity. The major issue with NIR dyes is their non-specific distribution and requirement of tagging with biomolecules for specific tissue localization. Till now, there have been no imaging agents available that can distribute into a specific organ without the need for targeted ligands, which remains as an unmet clinical need. In the present study, we demonstrate that the Zinnia elegans plant extract (abbreviated as ZE) assisted synthesis of highly biocompatible gold nanoparticles (AuZE), leading to their non-invasive bio-imaging applications in the NIR region (red at 820 nm emission: NIR region). AuZE and ZE both exhibited green fluorescence at 350 nm excitation and red fluorescence in the NIR region (710 nm). We verified the source of this fluorescence, which originates from the fluorescent molecules present in the ZE extract. After intraperitoneal administration in C57BL6 mice, very interestingly, AuZE is distributed into the brain of C57BL6 mice without the need for any targeted ligand and exhibited bright red fluorescence in the NIR region (710 nm excitation, 820 nm emission) as evidenced by non-invasive imaging as well as ICPOES techniques. We further explored the activity of ZE and AuZE as cell labeling agents (B16F10 cells were pre-incubated with AuZE and implanted into mice, and the fluorescence was monitored), which could be applicable for graft transplantation biology. To the best of our knowledge, this is the first report that demonstrates the versatile applications of green synthesized gold nanoparticles using a ZE extract. Considering these exciting results and fruitful outcomes, the ZE and AuZE NPs would stand as an alternative imaging agent to commercially available NIR dyes and change the conventional fluorescence-based bioimaging strategies. Therefore, the biosynthesized AuNPs open new directions for future research to explore these latest observations in the field of disease diagnosis and therapy.

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Section: ■ Introductionmentioning

confidence: 99%

Biosynthesized Gold Nanoparticles: In Vivo Study of Near-Infrared Fluorescence (NIR)-Based Bio-imaging and Cell Labeling Applications

Kotcherlakota

Nimushakavi

Roy

et al. 2019

ACS Biomater. Sci. Eng.

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show abstract

“…It is expected that ZnO nanocrystals doped with lanthanide ions will form a photoluminescent material in the near infrared region of 800–1400 nm (NIR) [ 14 , 15 ]. In particular, ZnO nanocrystals doped with neodymium ions, which have several important luminescent bands in the NIR region, including the transitions 4 F 3/2 → 4 I 9/2 (at ∼ 900 nm), 4 F 3/2 → 4 I 11/2 (1060 nm) and 4 F 3/2 → 4 I 13/2 (1340 nm) [ 16 ], are of interest for applications as luminescent biomarkers, as maximal light transmission of biological tissues is reported to be in the 850–1100 nm region [ 17 ]. Among the other applications, Nd-doped ZnO NPs have shown promising photocatalytic properties for water purification [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Photoluminescent neodymium-doped ZnO nanocrystals prepared by laser ablation in solution for NIR-II fluorescence bioimaging

Tarasenka¹,

Kornev

Ramanenka

et al. 2022

Heliyon

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New advances in pre-clinical diagnostic imaging perspectives of functionalized upconversion nanoparticle-based nanomedicine

Ansari

Parchur

Thorat

et al. 2021

Coordination Chemistry Reviews

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Bovine Serum Albumin Coated Upconversion Nanoparticles for Near Infrared Fluorescence Imaging in Mouse Model

Cited by 7 publications

References 0 publications

Biosynthesized Gold Nanoparticles: In Vivo Study of Near-Infrared Fluorescence (NIR)-Based Bio-imaging and Cell Labeling Applications

Biosynthesized Gold Nanoparticles: In Vivo Study of Near-Infrared Fluorescence (NIR)-Based Bio-imaging and Cell Labeling Applications

Photoluminescent neodymium-doped ZnO nanocrystals prepared by laser ablation in solution for NIR-II fluorescence bioimaging

New advances in pre-clinical diagnostic imaging perspectives of functionalized upconversion nanoparticle-based nanomedicine

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