New advances in pre-clinical diagnostic imaging perspectives of functionalized upconversion nanoparticle-based nanomedicine

Ansari, Anees A.; Parchur, Abdul K.; Thorat, Nanasaheb D.; Chen, Guanying

doi:10.1016/j.ccr.2021.213971

Cited by 69 publications

(44 citation statements)

References 288 publications

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“…We also assessed the effect of the addition amount of capture probe on the fluorescence intensity of the immunoassay. Various amounts (5,10,15,20,25,30,35, and 40 µL) of the capture probe (2.5 mg mL −1 ) were incubated for 1 h with 25 µL of signal probe (2.5 mg mL −1 ), respectively. Then immune complex was separated by a magnet and washed three times with PBS buffer, and the fluorescence intensity was recorded by the fluorescence spectrophotometer.…”

Section: Optimization Of Conditionsmentioning

confidence: 99%

“…Compared with traditional down-conversion fluorescence materials, upconversion nanoparticles (UCNPs) have attracted enormous scientific interest owing to their excellent features, including large anti-Stokes shifts, biocompatibility, low autofluorescence background [ 24 ]. In recent years, UCNPs have been widely used in biological imaging, labeling, photodynamic therapy, and anti-counterfeit [ 25 , 26 , 27 , 28 ]. Therefore, an attempt has been made to establish a fluorescence immunoassay by combining the signal amplification effect of UCNPs and the rapid separation ability of magnetic nanoparticles (MNPs) to achieve rapid and sensitive detection of IQ in heat processed meat.…”

Section: Introductionmentioning

confidence: 99%

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Upconversion Nanoparticles-Based Fluorescence Immunoassay for the Sensitive Detection of 2-Amino-3-methylimidazo [4,5-f] Quinoline (IQ) in Heat Processed Meat

Huang

Sheng

Chen

et al. 2021

Sensors

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A competitive fluorescence immunoassay for the quantitative detection of 2-amino-3-methylimidazo [4, 5-f] quinoline (IQ) in pan-fried meat patties was developed, using magnetic nanoparticles coupled with coating antigen as the capture probe and anti-IQ antibody coupled with NaYF4: Yb, Er upconversion nanoparticles as the signal probe. Under optimal conditionals, the wide detection range for IQ in phosphate buffer saline is from 0.01 to 100 μg·L−1 (R2 = 0.991) with a detection limit of 0.007 μg·L−1. This proposed method has been applied to detect IQ in two different types of pan-fried meat patties at varying frying times, and the IQ content in chicken patties and fish patties are 2.11–3.47 μg·kg−1 and 1.35–2.85 μg·kg−1, respectively. These results are consistent with that of the ultraperformance liquid chromatography-tandem mass spectrometry. In summary, this method can serve as a sensitive and specific test tool for the determination of IQ in processed meat.

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Section: Optimization Of Conditionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Upconversion Nanoparticles-Based Fluorescence Immunoassay for the Sensitive Detection of 2-Amino-3-methylimidazo [4,5-f] Quinoline (IQ) in Heat Processed Meat

Huang

Sheng

Chen

et al. 2021

Sensors

View full text Add to dashboard Cite

show abstract

“…Many researchers have recently advocated that this system be employed in biological imaging since it provides considerable benefits in the treatment against major illnesses such as cancer. However, the typical challenge is that it has insufficient light intensity and is poisonous to biological cells; therefore, its structure and surface must be modified [2]. Many scholars have proposed doping Mo 3+ , Cu 2+ [3,4], and other metal ions in the NaYF 4 :Yb 3+ /Er 3+ unit cell to increase the luminous intensity [5,6], but the effect is not significant.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Therapy and Multi-Modality Imaging of Up-Conversion Nanomaterial Doped with AuNPs

Zhang

Zang

et al. 2022

IJMS

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Two key concerns exist in contemporary cancer chemotherapy in clinic: limited therapeutic efficiency and substantial side effects in patients. In recent years, researchers have been investigating a revolutionary cancer treatment technique, and photodynamic therapy (PDT) has been proposed by many scholars. A drug for photodynamic cancer treatment was synthesized using the hydrothermal method, which has a high efficiency to release reactive oxygen species (ROS). It may also be utilized as a clear multi-modality bioimaging platform for photoacoustic imaging (PAI) due to its photothermal effect, computed tomography (CT), and magnetic resonance imaging (MRI). When compared to single-modality imaging, multi-modality imaging delivers far more thorough and precise details for cancer diagnosis. Furthermore, Au-doped up-conversion nanoparticles (UCNPs) have an exceptionally high luminous intensity. The Au-doped UCNPs, in particular, are non-toxic to tissues without laser at an 808 nm wavelength, endowing the as-prepared medications with outstanding therapeutic efficacy but exceptionally low side effects. These findings may encourage fresh effective imaging-guided approaches to meet the goal of photodynamic cancer therapy to be created.

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“…In particular, because of the high atomic numbers of both Ba and Gd, improved contrast of computed tomography (CT) could be obtained. 44–48 Therefore, we proposed that the homing efficiency of stem cells could be assessed by labelling cells with BaGdF 5 nanoparticles and monitoring with imaging techniques. To verify this hypothesis, we synthesized and modified uniform BaGdF 5 :Yb,Tm nanoparticles, evaluated their possibility of labelling stem cells, and used micro-CT to visualize whether the cells can migrate to the injury site.…”

Section: Introductionmentioning

confidence: 99%

Labelling stem cells with a nanoprobe for evaluating the homing behaviour in facial nerve injury repair

et al. 2022

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New advances in pre-clinical diagnostic imaging perspectives of functionalized upconversion nanoparticle-based nanomedicine

Cited by 69 publications

References 288 publications

Upconversion Nanoparticles-Based Fluorescence Immunoassay for the Sensitive Detection of 2-Amino-3-methylimidazo [4,5-f] Quinoline (IQ) in Heat Processed Meat

Upconversion Nanoparticles-Based Fluorescence Immunoassay for the Sensitive Detection of 2-Amino-3-methylimidazo [4,5-f] Quinoline (IQ) in Heat Processed Meat

Photodynamic Therapy and Multi-Modality Imaging of Up-Conversion Nanomaterial Doped with AuNPs

Labelling stem cells with a nanoprobe for evaluating the homing behaviour in facial nerve injury repair

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