Bovine serum albumin nanoparticles as controlled release carrier for local drug delivery to the inner ear

Abstract

Nanoparticles have attracted increasing attention for local drug delivery to the inner ear recently. Bovine serum albumin (BSA) nanoparticles were prepared by desolvation method followed by glutaraldehyde fixation or heat denaturation. The nanoparticles were spherical in shape with an average diameter of 492 nm. The heat-denatured nanoparticles had good cytocompatibility. The nanoparticles could adhere on and penetrate through the round window membrane of guinea pigs. The nanoparticles were analyzed as drug carriers to investigate the loading capacity and release behaviors. Rhodamine B was used as a model drug in this paper. Rhodamine B-loaded nanoparticles showed a controlled release profile and could be deposited on the osseous spiral lamina. We considered that the bovine serum albumin nanoparticles may have potential applications in the field of local drug delivery in the treatment of inner ear disorders.

Efficient approach to enhance drug solubility by particle engineering of bovine serum albumin

“…Bovine serum albumin (BSA) is chemically similar to human albumin and is widely used in pharmaceutical industry owing to its abundance, low cost, ease of purification, biocompatibility and biodegradability (Yu et al, 2014).…”

Silk Fibroin Nanoparticles for Drug Delivery: Effect of Bovine Serum Albumin and Magnetic Nanoparticles Addition on Drug Encapsulation and Release

“…Silk fibroin-bovine serum albumin nanoparticles were prepared since bovine serum albumin has been found to be biocompatible, biodegradable, non-toxic, and non-immunogenic and has interesting results in drug encapsulation and release [16]. Finally, magnetic silk fibroin nanoparticles were also prepared and examined to identify the contribution of magnetic nanoparticles to the encapsulation efficiency and in vitro drug release of the model drugs.…”

Development of biocompatible and VEGF-targeted paclitaxel nanodrugs on albumin and graphene oxide dual-carrier for photothermal-triggered drug delivery in vitro and in vivo

“…35 Apart from GO, other organic materials such as liposomes, hydrogels, and serum albumin can also be used as drug carriers. [36][37][38][39] Compared with these carriers, serum albumin as an endogenous protein with good biocompatibility, non-toxicity, and non-immunogenicity has become one of the most exciting carriers to deliver insoluble anticancer drugs. [40][41][42] Moreover, the presence of functional carboxylic and amino groups on the surface facilitates surface functionalization for albumin nanoparticles such as conjugation of targeting moieties.…”