Bovine viral diarrhoea virus (BVDV) diversity and vaccination. A review

Kalaycioglu, Atila T.

doi:10.1080/01652176.2007.9695228

Cited by 37 publications

(20 citation statements)

References 77 publications

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“…A variety of viruses are capable of crossing the placenta causing a variety of effects after foetal infection. The most important consequence of a NCP BVDV infection during pregnancy is the birth of persistently infected immunotolerant calves shedding large amounts of virus, thereby constituting a key element in viral spread (Kalaycioglu, 2007). Whether the North‐Western European BTV‐8 strain is able to induce a similar effect has been the topic of constant debate and the devastating effects of BTV reported by Luedke et al.…”

Section: Discussionmentioning

confidence: 99%

Transplacental Infection and Apparently Immunotolerance Induced by a Wild-type Bluetongue Virus Serotype 8 Natural Infection

Clercq

Leeuw

Verheyden

et al. 2008

Transboundary and Emerging Diseases

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Until recently, bluetongue (BT) virus (BTV) serotypes reportedly causing transplacental infections were all ascribed to the use of modified live virus strains. During the 2007 BT epidemic in Belgium, a significant increase in the incidence of abortions was reported. A study including 1348 foetuses, newborns and young animals with or without suspicion of BTV infection, was conducted to investigate the occurrence of natural transplacental infection caused by wild-type BTV-8 and to check the immunocompetence of newborns. BTV RNA was present in 41% and 18.5% of aborted foetuses from dams with or without suspected BTV involvement during pregnancy, respectively. The results of dam/calf pairs sampled before colostrum uptake provide evidence of almost 10% transplacental BTV infection in newborns. Apparently immunotolerant calves were found at a level of 2.4%. The current study concludes that the combined serological and real-time PCR (RT-qPCR) result of pregnant dams gives no indication of the infection status of the offspring except in the case of a double negative result. In a group of 109 calves with clinical suspicion of BT, born during the vector-free period, 11% were found to be RT-qPCR positive. The true prevalence was estimated to be 2.3%, indicating the extent of transplacental infection in a group of 733 calves of one to 4 months of age without BT suspicion. Moreover, virus isolation was successful for two newborn calves, emphasizing the need for restricting trade to BT-free regions of pregnant dams possibly infected during gestation, even if they are BTV RT-qPCR negative.

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Section: Discussionmentioning

confidence: 99%

Transplacental Infection and Apparently Immunotolerance Induced by a Wild-type Bluetongue Virus Serotype 8 Natural Infection

Clercq

Leeuw

Verheyden

et al. 2008

Transboundary and Emerging Diseases

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“…Both diseases are important from a clinical and economical point of view (Kalaycioglu 2007;Laureyns et al 2010). Reproductive diseases are the main disorders responsible for economic losses (Grooms 2004).…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence and risk factors associated with bovine viral diarrhea virus (BVDV) infection in non-vaccinated dairy and dual purpose cattle herds in Ecuador

Saa

Perea

García‐Bocanegra

et al. 2011

Trop Anim Health Prod

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A cross-sectional study was carried out to determine the seroprevalence and risk factors associated with Bovine viral diarrhea virus (BVDV) infection in non-vaccinated dairy and dual-purpose cattle herds from Ecuador. A total of 2,367 serum samples from 346 herds were collected from June 2008 through February 2009. A questionnaire, which included variables related to cattle, health, management measures, and the environment, was filled out in each herd. A commercial indirect enzyme-linked immunosorbent assay test was used to determine the seropositivity. A logistic regression model was used to determine risk factors at herd level. The individual seroprevalence for BVDV in non-vaccinated herds in Ecuador was 36.2% (857/2,367; CI(95%), 34.3-38.1%). The herd prevalence was 74% (256/346; CI(95%), 69.4-78.6%) and the intra-herd prevalence ranged between 11.1% and 100% (mean = 51.6%). The logistic regression model showed that the density of cattle farms in the area (more than 70%; OR, 1.94; CI(95%), 1.21-3.2) and the altitude (higher than 2,338 m above sea level; 2.33; CI(95%), 1.4-3.9) are potential risk factors associated with BVDV infection.

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“…Although the efficiency of inactivated vaccines is strongly and directly related to antigen concentration, the number and route of administration, individual immunity discrepancies, specificity of detection methods, type of adjuvant, and strains of virus selected for vaccination are also critical factors for the level of antibodies detected after BVDV immunization (16)(17)(18)(19)(20)(21). In previous studies, effects of vaccine types on the level of immune response (22), differences in cross-protective immune response between different BVDV subgenotypes (23), or adverse effect, i.e.…”

Section: Discussionmentioning

confidence: 99%

Neutralizing antibody titers against field strains of bovine viral diarrhea virus after vaccination with three commercial vaccines

Alpay¹,

Yeşilbağ²

2019

Turk J Vet Anim Sci

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Modified killed vaccines against bovine viral diarrhea virus (BVDV) are used worldwide. In the present study, the crossneutralization antibody responses against field strains from seven subgenotypes of BVDV-1 and one subgenotype of BVDV-2 were evaluated using sera obtained by three inactivated commercial vaccines. One vaccine contained both BVDV-1 and BVDV-2 strains, while the others contained only BVDV-1a. Three vaccine groups, each containing five calves, were vaccinated two times with 30day intervals. The antibody titers were evaluated by virus neutralization assay. The monovalent vaccine induced the highest antibody titers. Significant levels of neutralizing antibody titers were maintained up to the last sampling time. Although one vaccine contained the BVDV-2 strain, the lowest antibody titers were detected against field strains from BVDV-2, BVDV-1b, and BVDV-1r. This study indicated that cross-protective immune responses with the most common international BVDV vaccine strains need to be evaluated with challenge experiments against field strains for efficient protection.

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Bovine viral diarrhoea virus (BVDV) diversity and vaccination. A review

Cited by 37 publications

References 77 publications

Transplacental Infection and Apparently Immunotolerance Induced by a Wild-type Bluetongue Virus Serotype 8 Natural Infection

Transplacental Infection and Apparently Immunotolerance Induced by a Wild-type Bluetongue Virus Serotype 8 Natural Infection

Seroprevalence and risk factors associated with bovine viral diarrhea virus (BVDV) infection in non-vaccinated dairy and dual purpose cattle herds in Ecuador

Neutralizing antibody titers against field strains of bovine viral diarrhea virus after vaccination with three commercial vaccines

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