Bovine viral diarrhoea virus (BVDV) subgenotypes in diagnostic laboratory accessions: Distribution of BVDV1a, 1b, and 2a subgenotypes

Fulton, Robert W.; Ridpath, Julia F.; Ore, Sharon; Confer, Anthony W.; Saliki, Jeremiah T.; Burge, Lurinda J.; Payton, Mark E.

doi:10.1016/j.vetmic.2005.10.002

Cited by 79 publications

(76 citation statements)

References 24 publications

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“…Factors associated with host, the environment and agent can influence the clinical outcome of BVDV (Baker 1995, Hamers et al 2001) and despite Jones et al (2004) and Baule et al (2001) related to subgenotypes BVDV-1b and BVDV-1d with respiratory disease, a correlation between BVDV genotypes and subgenotypes and clinical signs has not yet been evidenced (Ripath et al 1994, Lettelie et al 1999, Fulton et al 2005.…”

Section: Discussion Discussion Discussion Discussionmentioning

confidence: 99%

Genetic characterization of Brazilian bovine viral diarrhea virus isolates by partial nucleotide sequencing of the 5'-UTR region

et al. 2006

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As amostras foram agrupadas em BVDV-1 (11/19), BVDV-2 (6/19) e num terceiro grupo de amostras denominadas "atípicas" (2/ 19). Das onze amostras genotipadas como BVDV-1, oito amostras foram sub-genotipadas como BVDV-1a, enquanto que a maioria (4/6) das amostras de BVDV-2 foi agrupada como BVDV2b. Duas amostras provenientes de fetos bovinos abortados foram classificadas como atípicas, não BVDV-1 e 2. A presença da diversidade genética de BVDV detectada nas amostras estudadas pode ser responsável por falhas vacinais e de diagnóstico e deve influenciar nas estratégias de controle do BVDV aplicadas nas diferentes regiões brasileiras.TERMOS DE INDEXAÇÃO: BVDV-1, BVDV-2, Pestivirus, Brazil, análise filogenética. INTRODUCTION INTRODUCTION INTRODUCTION INTRODUCTION INTRODUCTIONInfections of cattle by bovine viral diarrhea virus (BVDV) are widespread cause of major economic losses to the cattle industry (Houe 1999). Clinical symptoms may involve the reproductive, respiratory, immune, and gastrointestinal systems, with signs that may range from disease with high mortality rates to asymptomatic infections. The latter is observed in most cases (Pellerin et al. 1994, Ridpath et al.1994, Baker 1995, Fray et al. 2000.BVDV is an enveloped RNA virus that belongs to family Flaviviridae, genus Pestivirus. The viral positive single stranded genome of approximately 12.5 kb in size contains a single open reading frame (ORF) flanked by two non-translating terminal regions, named 5' and 3'-UTR. The single ORF is directly translated and gives rise to a long polyprotein which is co-translationally cleaved, originating 10 to 12 mature viral proteins (Collet et al. 1988, Meyer et al. 1989.Isolates have been subdivided in genotypes BVDV-1 and BVDV-2. These were further split into subgenotypes.

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Section: Discussion Discussion Discussion Discussionmentioning

confidence: 99%

Genetic characterization of Brazilian bovine viral diarrhea virus isolates by partial nucleotide sequencing of the 5'-UTR region

et al. 2006

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“…In 2013 a BVDV-1q subgroup was isolated from a Bactrian camel in China (Gao et al 2013). There is less diversity between BVDV-2 isolates, with two subtypes, 2a and 2b, identified (Fulton et al 2005;Flores et al 2002), although, a third subtype, 2c has been proposed (Tajima et al 2001). This subtype was found to be the cause of a severely virulent BVD outbreak in Germany during 2012 and 2013 (Doll and Holsteg 2013).…”

Section: Figure 12: Structure Of the Bvdv Genomementioning

confidence: 99%

“…This specialised technique is relatively expensive however, and may take up to 14 days to achieve a definitive result. BVDV grows particularly well in bovine turbinate cells (BT-), bovine testicle cells (Btest-) and Madin Darby bovine kidney cells (MDBK) (Dubovi 2013;Fulton et al 2005). Certain strains of BVDV can be identified in a cell culture by their cytopathic effect on cells (cp biotype) but in the majority of isolates (ncp biotype) fluoresced labelled or enzyme-marked monoclonal or polyclonal antibodies against viral antigens must be used to detect virus replication (Sandvik, 1999).…”

Section: Laboratory Diagnosismentioning

confidence: 99%

“…classified as BVDV-1a while the remaining 26% were identified as BVDV-2a (Fulton et al 2005). In Brazil, a large scale search for ruminant Pestiviruses in 2010 identified 33 viruses which were amplified and subsequently genotyped.…”

Section: Prevalence Of Bvdv Genotypes and Sub-genotypesmentioning

confidence: 99%

“…The sub-division of both species of BVDV has been documented with the more genetically diverse, BVDV-1, containing 17 subgenotypes (Gao et al 2013). Two subgenotypes of BVDV-2 (BVDV type 2a and BVDV type 2b) have also been demonstrated in a number of studies (Fulton et al 2005;Flores et al 2002). A third subtype was tentatively suggested in 2001 (Tajima et al 2001) prior to a German outbreak of BVDV in 2012…”

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Genetic typing of bovine viral diarrhoea virus in cattle on Irish farms

O’Brien

Garvey

Walsh

et al. 2017

Research in Veterinary Science

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The genotype and subgenotype was established for 325 field viruses and one commercial vaccine viral strain based on the analysis of at least one genomic region. BVDV-1a was the prominent subgenotype (n=317) with BVDV-1b (n=6), BVDV-1d (n=1) and BVDV-1e (n=1) also observed. A number of nucleotide sequence alignments and phylogenetic trees were constructed to represent the relationship between Irish field viruses and reference strains representative of all known BVDV genotypes and subgenotypes. Evidence of both herd specific clustering and circulation of multiple strains within herds was observed; however no evidence of county specific clustering was observed. A number of completely conserved nucleotide regions were observed and the 5'UTR was found to be more conserved than the N pro fragment analysed. The results of this study provide a detailed and comprehensive insight into the genetic diversity of BVDV in circulation within Irish cattle herds and will act as a baseline reference for future BVDV genotyping studies.

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Infectious Agents

Passler

2014

Bovine Reproduction

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Bovine viral diarrhoea virus (BVDV) subgenotypes in diagnostic laboratory accessions: Distribution of BVDV1a, 1b, and 2a subgenotypes

Cited by 79 publications

References 24 publications

Genetic characterization of Brazilian bovine viral diarrhea virus isolates by partial nucleotide sequencing of the 5'-UTR region

Genetic characterization of Brazilian bovine viral diarrhea virus isolates by partial nucleotide sequencing of the 5'-UTR region

Genetic typing of bovine viral diarrhoea virus in cattle on Irish farms

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