Boysenberry Polyphenols Suppressed Elevation of Plasma Triglyceride Levels in Rats

Mineo, Shigeru; Noguchi, Akane; Nagakura, Yuta; Kobori, Kinji; Ohta, Tatsuo; Sakaguchi, Ei; Ichiyanagi, Tsuyoshi

doi:10.3177/jnsv.61.306

Cited by 22 publications

(16 citation statements)

References 25 publications

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“…Thus the sterols in D. indica fruit extract in ethanol may inhibit lipase, thereby ameliorating fat malabsorption in the intestinal lumen by forming an irreversible bond with fat molecules and ultimately leading to fecal excretion without degradation. Moreover, it has been reported that polyphenols in boysenberry and okra extract suppressed enhancement of TG in plasma [80, 81]; this is consistent with our study, where polyphenol in D. indica fruit may lower TG levels in hypercholesterolemic rats. Diacylglycerol acyltransferase 2 (DGAT2) catalyzes the last step of TG biosynthesis in rodents [82].…”

Section: Discussionsupporting

confidence: 93%

Dillenia indica fruit extract has Glucose and Cholesterol Lowering effects

Khan

Bhowmik

Rhaman

et al. 2019

Preprint

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27 Background: Dillenia indica (D. indica) can suppress carbohydrates 28 hydrolysis by inhibiting α-amylase and α-glucosidase. However, there is a lack 29 of understanding of its therapeutic potential as an antidiabetic and anti-30 hyperlipidemic agent. 31Methods and findings: Type 2 diabetes (T2D) was induced by a single 32 intraperitoneal injection of Streptozotocin (STZ; 90mg/kg) and hyperlipidemia 33 by feeding with 1% cholesterol, 5% coconut oil and 5% cow fat diet. 34Administration of D. indica extracts in water for four weeks triggered a 35 significant (p≤0.05) reduction in fasting serum glucose (FSG) levels with 36 concomitant improvement in serum insulin levels. Both the water-and 37 ethanol-extract of D. indica treated groups showed significant (p≤0.01) 38 reduction in total cholesterol levels by 25% and 19%, respectively. HDL-39 cholesterol was also augmented (by 14%) in ethanol-extract treated group. 40Liver glycogen content was higher in the water-extract treated group. 41Histopathological examination revealed that there was no tubular epithelial 42 cell degeneration or necrosis in the renal tissues or hepatocyte degeneration 43 and sinusoidal dilation in liver tissues in animals that received the water-44 extract. On the other hand, consumption of D. indica extract with 1% 45 cholesterol, 5% coconut oil diet or with a 5% cow fat diet for 14 days 46 significantly reduced serum cholesterol levels in group-lll (60→45 mg/dl; 47 p≥0.05) and -IV (85→66 mg/dl; p≥0.05) hypercholesterolemic model rats. D. 48 indica fruit extract also reduced serum TG levels (Group-III: 87→65 mg/dl; 49 Group-IV: 40→90 mg/dl; p≥0.05). Interestingly, treatment with D. indica Page 3 of 52 50 prevented a reduction in serum HDL levels in those hypercholesterolemic 51 model rats. Serum LDL levels were significantly lower in group-III (47→39 52 mg/dl; p≥0.05) and group-IV (57→44 mg/dl; p≥0.05) hypercholesterolemic 53 model rats after D. indica treatment. 54 Conclusion: D. indica fruit ameliorates FSG, insulin secretion, glycogen 55 synthesis, and serum lipid profile. Therefore, D. indica fruit can be a potential 56 therapeutic agent for diabetic and hyperlipidemia. Introduction 75 Diabetes mellitus is a chronic metabolic disorder characterized by on-going 76 hyperglycemia. Insulin resistance and decreased insulin secretion are the two 77 cardinal features of type 2 diabetes mellitus (T2DM). T2DM is typically 78 diagnosed based on glucose levels, either a fasting plasma glucose (FPG) ≥ 79 7.0 or a 2-hour 75 g oral glucose tolerance test (OGTT) ≥ 11.1 mmol/L levels. 80 Pre-diabetic classifications include a fasting blood glucose (FBG) of 5.6-81 6.9 mmol/L or a 2-hour blood glucose level of ≥7.8 and < 11.1 mmol/L [1]. 82 T2DM is often accompanied by cardiovascular disease, diabetic neuropathy, 83 nephropathy, and retinopathy. An altered lipid profile is common in T2DM 84 patients. Furthermore, reduced hepatic glycogen storage is also observed in 85 diabetes [2-4]. Advancements in the modern lifestyle over the last century 86 have contr...

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Section: Discussionsupporting

confidence: 93%

Dillenia indica fruit extract has Glucose and Cholesterol Lowering effects

Khan

Bhowmik

Rhaman

et al. 2019

Preprint

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“…Green tea catechins, cacao oligomeric procyanidins, and glucomannan have been shown to reduce lipid absorption [5][6][7][8]. Resveratrol, a natural polyphenolic compound found in berries, has been shown to regulate lipid metabolism through AMP-activated protein kinase α (AMPKα), silent information regulator 2 homolog 1 (Sirt1), and the peroxisome proliferator-activated receptor γ (PPARγ) pathway in zebrafish [9].…”

mentioning

confidence: 99%

Daily consumption of monoglucosyl-rutin prevents high-fat diet-induced obesity by suppressing gastric inhibitory polypeptide secretion in mice

Yokoyama¹,

Tanaka²,

Hashizume³

et al. 2018

FFHD

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Citation: Yokoyama D., Tanaka W., Hashizune Y., Tandia M., Sakono M., Shimoi K., Sakakibara H. Daily consumption of monoglucosyl-rutin prevents high-fat diet-induced obesity by suppressing gastric inhibitory polypeptide secretion in mice. ABSTRACTBackground: Alpha monoglucosyl-rutin (4 G -α-D-glucopyranosyl rutin, αMR) has been shown to stimulate antioxidant defenses and anti-glycation. We evaluated the effects of αMR on body weight gain in mice. Methods:Male C57BL/6J mice were divided into four groups: Control low-fat diet, low-fat Page 354 of 371 diet + 0.5% αMR, high-fat diet, and high-fat diet + 0.5% αMR. Blood chemistry, hepatic lipids, and serum metabolic hormones and cytokines were evaluated after 4 and 13 weeks.Results: After 6 weeks, the high-fat diet group gained more weight than the low-fat diet group. Supplementing the high-fat diet with αMR suppressed weight gain by week 13.Visceral fat weight was higher in the high-fat diet group on weeks 4 and 13, while αMR supplementation inhibited increase on week 13 but not on week 4. Serum levels of gastric inhibitory polypeptide were higher in the high-fat-diet group than in the low-fat-diet group.αMR supplementation inhibited this elevation and regulated levels of serum leptin and hepatic triglycerides. Conclusion:For the first time, we demonstrated how daily consumption of αMR inhibits diet-induced visceral fat accumulation by regulating the secretion of gastric inhibitory polypeptide, which thereby prevents excess weight gain. Therefore, αMR may be a promising potential functional food. BACKGROUNDThe analysis of life insurance data reveals how obesity is associated with increased death rates, as obesity involves highly elevated risks of adverse health outcomes such as type 2 diabetes mellitus and cardiovascular disease [1,2]. Obesity can be categorized either as total obesity (body mass index ≥ 25.0 kg/m 2 ) and severe obesity (body mass index ≥ 30.0 kg/m 2 ).The prevalence of obesity worldwide has been estimated to reach 18% for men and surpass 21% for women by 2025, with severe obesity surpassing 6% in men and 9% in women in developed countries [3]. The economic burden of obesity-related diseases has been estimated to be around $48-66 billion/year in the US and £1.9-2 billion/year in the UK by 2030 [4]. Therefore, prevention of excess body weight gain and obesity is a high research priority.Weight gain results from a chronic positive energy balance, occurring when energy expenditure is lower than energy intake. Consequently, management of daily food αMR, α-monoglucosyl rutin; LFD, low-fat diet (control); HFD, high-fat diet. 1 Energy values were calculated using Atwater factors; 4 kcal/g for soluble nitrogen-free products and crude protein, and 9 kcal/g for crude lipid.

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“…We hypothesized that the inhibitory effect of AE on pancreatic lipase was attributable to polyphenol or SDF present in the AE. As previously reported, SDF and polyphenol have lipase-inhibiting activity (24,30). Slanc et al reported that methanol extracts from Pisum sativum inhibited pancreatic lipase activity in vitro, and the removal of polyphenol from the extract decreased its inhibitory activity to less than 40% of the control (31).…”

Section: Discussionmentioning

confidence: 58%

Hypolipidemic Effect of the Autoclaved Extract Prepared from Pea (<i>Pisum sativum</i> L.) Pods In Vivo and In Vitro

Inagaki

Nishimura

Iwata

et al. 2016

J Nutr Sci Vitaminol

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Summary By autoclaving, we obtained a polyphenol and dietary fiber from pea (Pisum sativum L.) pods in parallel without acid or alkali treatment or organic solvent extraction. Rats fed a high-sucrose (HS) diet containing 3% autoclaved extract (AE) for 4 wk exhibited significantly lower serum triglyceride and total cholesterol levels than rats fed a HS diet. AE and soluble dietary fiber (SDF) from AE exhibited pancreatic lipase inhibitory activity at 13.3 mg/mL in vitro. AE and insoluble dietary fiber (IDF) from AE adsorbed cholesterol. In total, 30% and 10% of a cholesterol micelle were significantly adsorbed by 2,000 mg of AE and 100 mg of IDF from AE in 7 mL, respectively. The amount of bifidobacteria in the cecum of the AE group was significantly increased compared with that in the HS group. These results suggest that AE has hypolipidemic, bifidogenic potential.

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Boysenberry Polyphenols Suppressed Elevation of Plasma Triglyceride Levels in Rats

Cited by 22 publications

References 25 publications

Dillenia indica fruit extract has Glucose and Cholesterol Lowering effects

Dillenia indica fruit extract has Glucose and Cholesterol Lowering effects

Daily consumption of monoglucosyl-rutin prevents high-fat diet-induced obesity by suppressing gastric inhibitory polypeptide secretion in mice

Hypolipidemic Effect of the Autoclaved Extract Prepared from Pea (<i>Pisum sativum</i> L.) Pods In Vivo and In Vitro

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