BPH Importance of prostate volume and urinary flow rate in prediction of bladder outlet obstruction in men with symptomatic benign prostatic hyperplasia

Trumbeckas, Darius; Milonas, Daimantas; Jievaltas, Mindaugas; Matjošaitis, Aivaras Jonas; Kinčius, Marius; Grybas, Aivaras; Kopustinskas, Vytis

doi:10.5173/ceju.2011.02.art5

Cited by 15 publications

(5 citation statements)

References 11 publications

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“…Secondly, the UFR data available in the NHANES database do not include peak UFR values or the systolic and diastolic values of the detrusor muscle, which directly reflect bladder contractile function. Nonetheless, the mean UFR data provided by NHANES can still serve as a valid reference indicator for assessing bladder function (16,17,55).…”

Section: Discussionmentioning

confidence: 99%

Sex-specific associations between nine metal mixtures in urine and urine flow rate in US adults: NHANES 2009–2018

Zhang

Tang

Zhou

2023

Front. Public Health

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BackgroundThe urinary system serves as a crucial pathway for eliminating metallic substances from the body, making it susceptible to the effects of metal exposure. However, limited research has explored the association between metal mixtures and bladder function. This study aims to investigate the relationship between urinary metal mixtures (specifically barium, cadmium, cobalt, cesium, molybdenum, lead, antimony, thallium, and tungsten) and urine flow rate (UFR) in the general population, utilizing multiple mixture analysis models.MethodsThis study utilizes data obtained from the National Health and Nutrition Examination Survey. After adjusting for relevant covariates, we assessed the correlations between metal mixtures and UFR using three distinct analysis models: weighted quantile sum (WQS), quantile g-computation (qgcomp), and Bayesian kernel machine regression (BKMR). Additionally, a gender-stratified analysis was conducted. Finally, we also performed sensitivity analyses.ResultsA total of 7,733 subjects were included in this study, with 49% being male. The WQS regression model, when fitted in the positive direction, did not yield any significant correlations in the overall population or in the male and female subgroups. However, when analyzed in the negative direction, the WQS index exhibited a negative correlation with UFR in the overall group (β = −0.078; 95% CI: −0.111, −0.045). Additionally, a significant negative correlation between the WQS index and UFR was observed in the female group (β = −0.108; 95% CI: −0.158, −0.059), while no significant correlation was found in the male group. The results obtained from the qgcomp regression model were consistent with those of the WQS regression model. Similarly, the BKMR regression model revealed a significant negative correlation trend between metal mixtures and UFR, with cadmium and antimony potentially playing key roles.ConclusionOur study revealed a significant negative correlation between urinary metal mixture exposure and mean UFR in US adults, with notable gender differences. Specifically, higher urinary levels of cadmium and antimony were identified as potential key factors contributing to the decrease in mean UFR. These findings significantly contribute to the existing knowledge on the impact of metal mixtures on bladder function and provide valuable insights for safeguarding bladder health and preventing impaired bladder function.

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Section: Discussionmentioning

confidence: 99%

Sex-specific associations between nine metal mixtures in urine and urine flow rate in US adults: NHANES 2009–2018

Zhang

Tang

Zhou

2023

Front. Public Health

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“…TURP has been performed in prostates of between 30 and 80 mL in approximately 95% of the cases (2). However, there is no strong evidence in the literature regarding the upper size limit of a prostate suitable for TURP (2,4). OP should be considered when the prostate is estimated to have a volume of more than 80 mL, as well as in some mandatory situations related to patients' co-morbidities, such as ankylosis of the hip or other orthopedic conditions preventing proper positioning for TURP, and in men with recurrent or complex urethral conditions, such as urethral stricture or previous hypospadias repair, in order to avoid urethral trauma associated with TURP (3,4).…”

Section: Discussionmentioning

confidence: 99%

“…About 30% of patients suffering from LUTS require surgery either because of insufficient palliative treatment with medication and/or disease progression (1). BPH is present in up to 50% of men over 60 years of age and nearly 88% of those 80 and older (2). Treatment options for BPH have expanded dramatically over the past two decades with the development of new strategies, including medical and minimally invasive treatments.…”

Section: Introductionmentioning

confidence: 99%

Abdominal or Transrectal Ultrasonographic Prostate Volume and Cystoscopic Prostatic Urethral Length Measurements to Determine the Surgical Technique for Prostatectomy in Patients with Benign Prostate Hyperplasia

Demir¹,

Karadağ²,

Çeçen³

et al. 2016

jus

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What's known on the subject? and What does the study add? ÖZ AmaçBiz bu çalışmada, prostatektomi açısından en uygun cerrahi yaklaşıma -endoskopik veya açık-karar vermek için, görüntüleme teknikleri ve rezeke edilen doku ağırlığı arasındaki ilişkiyi kullanarak, prostat hacim ölçümleri için en uygun tekniği belirlemeyi amaçladık. Gereç ve YöntemTransüretral rezeksiyon planlanan, alt üriner sistem yakınmaları bulunan, 49-95 yaşlarında 60 hasta çalışmamıza dahil edildi. Rezeke edilen doku ağırlığı, abdomimal ve cerrahi öncesi masada ölçülen transrektal ultrasonografi (TRUS) prostat boyutları ve sistoskopi esnasında ölçülen prostatik üretral uzunluk arasındaki ilişki incelendi. Prostat hacimleri açısından, 75 cc'den küçük eşit ve büyük ve de prostatik uzunluk ölçümlerine gore de 2,5 cm'den kısa ve uzun olmak üzere 2 grup oluşturuldu. Bu iki grup arasında, rezeke edilen doku ağırlığı ve cerrahi öncesi hacim ölçüm yöntemleri arasında en iyi ilişki belirlemek için istatistiksel analiz yapıldı. BulgularRezeke edilen doku ağırlığı ile prostatik hacim ölçümleri arasındaki en güçlü ilişki TRUS ölçümleri ile olanla saptandı (r=0,79; p<0,001). Abdominal ve TRUS prostat hacimleri ve prostatik üretra uzunluk katsayıları, sırasıyla, 0,127, 0,287 ve 0,219 idi. ObjectiveWe aimed to determine the most suitable technique for prostate volume (PV) measurement to decide for the most appropriate surgical approach -endoscopic or open -by establishing the relationship between imaging techniques and the resected tissue weight (RTW). Materials and MethodsSixty men aged 49-95 years with lower urinary tract symptoms, who were scheduled for transurethral resection, were enrolled. The relationship of RTW with PV determined by preoperative abdominal ultrasonography as well as transrectal ultrasonography (TRUS) performed at the table just before surgery, and prostatic urethral length (PUL) measured at the time of cystoscopy was analyzed. Two groups were established with respect to PV, (less than or equal to 75 cc and greater than 75 cc, respectively), and according to PUL (less than or equal to 2.5 cm and longer than 2.5 cm, respectively). Statistical analyses were performed between the groups to identify the best correlation between resected tissue weight and presurgical volume determination methods. ResultsThe strongest correlation between RTW and prostatic volume measurements was established for the TRUS measurements (r=0.79; p<0.001). The coefficients of the abdominal and transrectal ultrasonographic volume and PUL were 0.127, 0.287 and 0.219, respectively.The prostate volume (PV) is the most important parameter while taking a decision about surgical technique in case of needed. The aim of this work is to determine the most accurate technique about PV between 3 techniques that we used. If succeded this, it can be gave more information about surgical technique and hospitalization process to the patients, and also the preparation of the operation room to the operation team.

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“…2) BPH is characterized by the progressive growth of prostatic glandular epithelial and stromal elements, culminating in uncontrolled hyperplasia. 3) As the prostate enlarges, it tightens the urethra, prompting a weak urinary stream, incomplete bladder emptying, dysuria, nocturia, and bladder outlet obstruction. 4) Although the pathogenesis of BPH has not yet been totally explained, aging and elevated androgens are established risk factors for BPH.…”

Section: Introductionmentioning

confidence: 99%

Effect of <i>Veratrum maackii</i> on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats

Park

Seo

Wijerathne

et al. 2019

Biological & Pharmaceutical Bulletin

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Veratrum maackii (VM), a perennial plant in the Melanthiaceae family, has anti-hypertensive, anticholinergic, anti-asthmatic, anti-tussive, anti-fungal, anti-melanogenesis, and anti-tumor activities. Here, we investigated the therapeutic effect of VM on benign prostatic hyperplasia (BPH) in human normal prostate cell line (WPMY-1) and a testosterone propionate-induced BPH animal model. WPMY-1 cells were treated with VM (1-10 µg/mL) and testosterone propionate (100 nM). BPH in rats was generated via daily subcutaneous injections of testosterone propionate (3 mg/kg) dissolved in corn oil, for 4 weeks. VM (150 mg/kg) was administered daily for 4 weeks by oral gavage concurrently with the testosterone propionate. All rats were sacrificed and the prostates were dissected, weighed, and subjected to histological, immunohistochemical, and biochemical examinations. Immunoblotting experiments indicated that WPMY-1 cells treated testosterone propionate had increased expression of prostate specific antigen (PSA) and androgen receptor (AR), and treatment with VM or finasteride blocked this effect. In rat model, VM significantly reduced prostate weight, prostatic hyperplasia, prostatic levels of dihydrotestosterone (DHT), and expression of proliferation markers such as proliferating cell nuclear antigen (PCNA) and cyclin D1, but increased the expression of pro-apoptotic Bcl-2-associated X protein (Bax) and the cleavage of caspase-3. VM administration also suppressed the testosterone propionate-induced activation of nuclear factor-kappaB (NF-κB). Our results indicate that VM effectively represses the development of testosterone propionateinduced BPH, suggesting it may be a useful treatment agent for BPH.

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BPH Importance of prostate volume and urinary flow rate in prediction of bladder outlet obstruction in men with symptomatic benign prostatic hyperplasia

Cited by 15 publications

References 11 publications

Sex-specific associations between nine metal mixtures in urine and urine flow rate in US adults: NHANES 2009–2018

Sex-specific associations between nine metal mixtures in urine and urine flow rate in US adults: NHANES 2009–2018

Abdominal or Transrectal Ultrasonographic Prostate Volume and Cystoscopic Prostatic Urethral Length Measurements to Determine the Surgical Technique for Prostatectomy in Patients with Benign Prostate Hyperplasia

Effect of <i>Veratrum maackii</i> on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats

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