Effect of &lt;i&gt;Veratrum maackii&lt;/i&gt; on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats

Park, Hee-Seon; Seo, Chang‐Seob; Wijerathne, Charith Ub; Jeong, Hye-Yun; Moon, Og-Sung; Seo, Young-Won; Won, Young‐Suk; Son, Hwa–Young; Lim, Jong-Hwan; Kwon, Hyo Jung

doi:10.1248/bpb.b18-00313

Cited by 15 publications

(4 citation statements)

References 43 publications

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“…In this study, TP administration significantly increased the serum levels of testosterone and DHT, as well as AR expression in the prostate, in the control group compared to the sham group. These findings are consistent with the results of previous studies [ 25 , 44 ]. TH extract significantly decreased serum testosterone and DHT levels and reduced the protein expression of AR in the prostate.…”

Section: Discussionsupporting

confidence: 94%

Effects of Taraxaci Herba (Dandelion) on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats

Lee,

Song

2024

Nutrients

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Benign prostatic hyperplasia (BPH) is the non-malignant enlargement of the prostate, associated with lower urinary tract symptoms (LUTSs). Taraxaci Herba (TH), commonly known as dandelion, has traditionally been utilized in East Asia to treat symptoms related to LUTSs. Based on this traditional use, our study aimed to explore the inhibitory effects of TH on BPH progression using a testosterone propionate-induced rat model. To induce BPH, male Sprague Dawley rats were castrated and injected subcutaneously with testosterone propionate (3 mg/kg/day) for 28 days. Concurrently, TH extract was administered orally at doses of 100 and 300 mg/kg/day throughout the four-week period of testosterone propionate injections. The TH extract significantly reduced both the absolute and relative weights of the prostate, along with histopathological changes in the gland. Moreover, it lowered serum levels of testosterone and dihydrotestosterone and reduced the expression of the androgen receptor in the prostate. Additionally, the TH extract modulated the protein expressions of Bax and Bcl-2, which are key regulators of apoptosis in prostate cells. Collectively, our findings suggest that TH inhibits BPH development partially by modulating androgen signaling and inducing apoptosis within the prostate.

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Section: Discussionsupporting

confidence: 94%

Effects of Taraxaci Herba (Dandelion) on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats

Lee,

Song

2024

Nutrients

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“…Here, we showed that finasteride (positive control) decreased the serum level of testosterone and DHT. These findings are consistent with those of a previous study [43,44]. In addition, PD decreased the levels of testosterone and DHT in the serum and prostatic mRNA expression of 5α-reductase.…”

Section: Discussionsupporting

confidence: 93%

Protective Effect of Panicum dichotomiflorum in a Rodent Model of Testosterone-Induced Benign Prostatic Hyperplasia

Baek,

Hong,

Kim

et al. 2024

Sci. Pharm.

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Benign prostatic hyperplasia (BPH) is a common disease in aging men. Panicum dichotomiflorum (PD) is an annual grass species of Poaceae that is distributed worldwide. The present study examined whether PD has a protective effect against BPH. BPH was generated in rats by daily subcutaneous administration of testosterone for four weeks. During this period, the rats were also given daily oral gavages of an extract of PD (150 mg/kg). After the final treatment, all animals were euthanized and their prostates were collected and weighed. In BPH model rats, the prostate weight and levels of dihydrotestosterone (DHT) and 5α-reductase expression were inhibited following treatment with PD extract. Testosterone-induced increases in prostate gland epithelial thickness and expression of cyclin D1 and proliferating cell nuclear antigen (PCNA) were markedly suppressed in PD-treated rats, whereas cleaved caspase-3 levels were increased. PD administration also decreased the expression of transforming growth factor (TGF)-β and vascular endothelial growth factor (VEGF), the phosphorylation of Akt, and inflammatory cytokines levels. Taken together, these results show that PD extract protects against testosterone-induced BPH progression by alleviating prostate cell growth and reducing levels of growth factors and inflammatory cytokines, indicating that PD extract may have potential in protecting against BPH.

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“…1 In our previous reports, several extracts inhibited expressions of AR and PSA induced by testosterone and these extract showed therapeutic effect in BPH rat model. 38,39 Consistently, in this study, testosterone increased expression of AR and PSA in LNCaP cells. Notably, EV treatment attenuated expression of AR and PSA.…”

Section: Discussionsupporting

confidence: 87%

Eriochloa villosa Alleviates Progression of Benign Prostatic Hyperplasia in vitro and in vivo

Baek¹,

Hwang²,

Park³

et al. 2022

RRU

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Introduction Benign prostatic hyperplasia (BPH) is a non-neoplastic proliferative disease of the prostate. Eriochloa villosa (EV) reportedly possesses various pharmacological activities, including anti-lipase activity and modulation of various antioxidative enzymes. In this study, we investigate the therapeutic potential of EV against BPH in a testosterone-induced BPH rat model. Methods Rats were subjected to a daily subcutaneous injection of testosterone (3 mg kg −1 ) for 4 weeks to induce BPH. Along with testosterone, rats in the treatment group were administered finasteride (10 mg kg −1 ) or EV (150 mg kg −1 ) via oral gavage. Prostatic cancer (LNCaP) cell line was used to examine the effect of EV. Results Finasteride and EV significantly decrease the relative prostate weight, serum levels of dihydrotestosterone and testosterone, and prostate epithelial thickness. Testosterone injection induced prostatic hyperplasia and proliferating cell nuclear antigen expression; however, EV treatment significantly attenuated these effects. Moreover, finasteride- and EV-treated rats exhibit an increase in the number of TUNEL-positive cells and reduced Bcl-2 expression in the prostate tissues compared with the testosterone-treated animals. Furthermore, EV suppresses inflammatory cytokines, including interleukin (IL)-6 and IL-8, in the prostate tissues. Meanwhile, the expression of inflammatory mediator cyclooxygenase-2 is consistently upregulated in testosterone-treated rats, whereas EV treatment significantly reverses this effect. Notably, EV treatment suppresses malondialdehyde (MDA) levels and upregulates testosterone-induced catalase (CAT) expression. In addition, EV suppresses expression of androgen receptor (AR) and prostate-specific antigen (PSA) induced by testosterone in LNCaP cells. Conclusion The present study results suggest that EV regulates prostatic proliferation, apoptosis, response to inflammation, and oxidative stress in the BPH rat model, and may, therefore, serve as a useful therapeutic agent for BPH.

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Effect of <i>Veratrum maackii</i> on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats

Cited by 15 publications

References 43 publications

Effects of Taraxaci Herba (Dandelion) on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats

Effects of Taraxaci Herba (Dandelion) on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats

Protective Effect of Panicum dichotomiflorum in a Rodent Model of Testosterone-Induced Benign Prostatic Hyperplasia

Eriochloa villosa Alleviates Progression of Benign Prostatic Hyperplasia in vitro and in vivo

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