Brachytherapy and continuous infusion 5-fluorouracil for the treatment of locally advanced, lymph node negative, prostate cancer: A phase I trial

See, William A.; Dreicer, Robert; Wheeler, James; Forest, Paula K.; Loening, Stefan A.

doi:10.1002/(sici)1097-0142(19960301)77:5<924::aid-cncr18>3.0.co;2-5

Cited by 6 publications

(2 citation statements)

References 27 publications

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“…The rectum is at increased risk of injury when high doses are delivered by intraprostatic implants in addition to external radiation. Radioactive gold seeds placed into the prostate can deliver doses that exceed 70 cGy to portions of the rectum [18]. With external beam alone, acute gastrointestinal effects occur in 30% to 40% of patients and usually develop within four weeks of therapy.…”

Section: Radiation Protocols Causing Anorectal Damagementioning

confidence: 99%

See 1 more Smart Citation

Radiation damage to the rectum and anus: pathophysiology, clinical features and surgical implications

2002

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Radiation kills cancer cells by inducing various degrees of deoxyribonucleic acid fragmentation and disruption of intracellular membranes that lead to either immediate or delayed cell death. Although radiation can be effective in destroying cancer, its usefulness is limited by damage to normal tissues that surround the target tumour or those in the path of the radiation beam. The rectum and anus are damaged frequently during radiotherapy for abdominopelvic malignancy, including preresection therapy for rectal cancer. Such damage is often associated with lesions in the perineal skin, genitourinary tract, colon, and small intestine. Surgical intervention often is required for the most severe forms of these complications.

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Section: Radiation Protocols Causing Anorectal Damagementioning

confidence: 99%

“…The likelihood of radiation damage may be increased by radiosensitizers, such as Doxorubicin, 5‐fluorouracil, and oxygenation [17,18]. Conversely, agents such as 2‐mercaptopropionyl, vitamin E, and glutamine, appear to have radioprotectant properties [19–22].…”

Section: Predisposing Factorsmentioning

confidence: 99%