Brachytherapy for Intracranial Meningioma Using a Permanently Implanted Iodine-125 Seed

Obasi, Patrick C.; Barnett, Gene H.; Suh, John H.

doi:10.1159/000069502

Cited by 14 publications

(2 citation statements)

References 19 publications

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“…This strategy has been employed for both grade 1 (i.e., the classic benign meningioma), and grade 2 and 3 (i.e., atypical and malignant) tumors. In one series, 13 patients with newly diagnosed or recurrent meningioma received I-125 brachytherapy to a total dose of 70–170 Gy as definitive therapy [74]. Of the three patients who received a total dose greater than 100 Gy, all of them had evidence of vasogenic edema and/or radiation necrosis at follow-up.…”

Section: Radiation Treatment Effect In Various Radiation Modalitiesmentioning

confidence: 99%

Postradiation Imaging Changes in the CNS: How can we Differentiate Between Treatment Effect and Disease Progression?

et al. 2014

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A familiar challenge for neuroradiologists and neuro-oncologists is differentiating between radiation treatment effect and disease progression in the CNS. Both entities are characterized by an increase in contrast enhancement on MRI and present with similar clinical signs and symptoms that may occur either in close temporal proximity to the treatment or later in the disease course. When radiation-related imaging changes or clinical deterioration are mistaken for disease progression, patients may be subject to unnecessary surgery and/or a change from otherwise effective therapy. Similarly, when disease progression is mistaken for treatment effect, a potentially ineffective therapy may be continued in the face of progressive disease. Here we describe the three types of radiation injury to the brain based on the time to development of signs and symptoms – acute, subacute and late – and then review specific imaging changes after intensity-modulated radiation therapy, stereotactic radiosurgery and brachytherapy. We provide an overview of these phenomena in the treatment of a wide range of malignant and benign CNS illnesses. Finally, we review the published data regarding imaging techniques under investigation to address this well-known problem.

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Section: Radiation Treatment Effect In Various Radiation Modalitiesmentioning

confidence: 99%

Postradiation Imaging Changes in the CNS: How can we Differentiate Between Treatment Effect and Disease Progression?

et al. 2014

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“…Moreover, the use of SRS and radiotherapy significantly increases the incidence of radiation complications. Brachytherapy has been tried with 125 I sources intraoperatively with mixed results [22] . Complications include a rate of radiation necrosis requiring further surgical resection of 13% in one series.…”

Section: Rhabdoid Meningioma Treatmentmentioning

confidence: 99%