Bradycardia During Induction of Anesthesia with Sevoflurane in Children with Down Syndrome

Abstract

Bradycardia during anesthetic induction with sevoflurane was common in children with Down syndrome, with and without a history of congenital heart disease.

Do small doses of atropine (<0.1 mg) cause bradycardia in young children?

“…Nonetheless, some specific populations have incurred arrhythmias during sevoflurane anaesthesia. For example, up to 57% of children with Down syndrome develop bradycardia during sevoflurane anaesthesia 24. Additionally, sevoflurane prolongs the QT interval, but this is of limited clinical significance since it does not increase the dispersion of repolarisation 25.…”

Phenylephrine as a simulated intravascular epidural test dose in pediatrics: a pilot study

“…have reported that HR increases in children older than 3 years and remains unchanged in younger children and infants at 1 MAC of sevoflurane , Kraemer et al . have noticed a 12% incidence of bradycardia following sevoflurane induction in healthy children with the time to the HR nadir of 196 ± 116 s . Our study showed that two patients in the placebo group (#8 and # 9) responded with a decrease in HR at two MAC of sevoflurane with a nadir approximately at 1 min following the anesthetic induction (Table ).…”

El niño con Síndrome de Down en la Unidad de Cuidados Intensivos

“…Se ha descrito una mayor frecuencia de bradicardia en estos niños al recibir inducción anestésica con sevoflurano, independiente de la coexistencia de cardiopatía 38 . Habitualmente ésta es de fácil corrección y no se asocia a un peor pronóstico 39 .…”