Brain Abscesses Caused by Clostridium Septicum as a Complication of Hemolyticuremic Syndrome

Chiang, Vincent W.; Adelson, P. David; Poussaint, Tina Young; Hand, Matthew; Churchwell, Kevin B.

doi:10.1097/00006454-199501000-00019

Cited by 18 publications

(5 citation statements)

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“…These devitalised and anaerobic areas of brain tissue are ideal environments for C septicum to settle and hence allow CNS infection. Four of the six published cases of HUS and C septicum infection have a neurological focus; however, unlike our case, the majority are described as meningitis or cerebritis5–7 with only one previous case described as having focal brain abscess 8. The other cases were myonecrosis9 and septicaemia 2…”

Section: Discussionmentioning

confidence: 46%

A microbiological hazard of rural living:Clostridium septicumbrain abscess in a child withE coli0157 associated haemolytic uraemic syndrome: Figure 1

Williams¹,

Mitchell

Mitra

et al. 2012

BMJ Case Reports

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SummaryClostridium septicum infection in humans is rare and this is the second case report of focal C septicum brain abscesses associated with Escherichia coli 0157 haemolytic uraemic syndrome (HUS). The case presented in a child who lived on a rural farm. The abscesses initially progressed despite 7 months of appropriate antibiotic therapy and repeated image-guided aspiration. After definitive resection and prolonged antibiotic therapy, there was no recurrence. This case reminds us of this rare but important neurological complication of HUS and supports consideration of early definitive neurosurgical intervention in similar unusual cases. BACKGROUND

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Section: Discussionmentioning

confidence: 46%

A microbiological hazard of rural living:Clostridium septicumbrain abscess in a child withE coli0157 associated haemolytic uraemic syndrome: Figure 1

Williams¹,

Mitchell

Mitra

et al. 2012

BMJ Case Reports

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“…Only a single survivor has been previously reported (Table 1) [23]. In only one case did the manifestations of C. septicum develop more than 2 days into hospitalization for HUS.…”

Section: Discussionmentioning

confidence: 94%

“…In one case, the patient died on the first day of hospitalization of C. septicum-related sepsis and meningitis [24]. Four of the five previously reported C. septicum infections in children with HUS have involved the CNS, with radiologically evident gas in most of these children [23][24][25][26]. Another child had abdominal wall spread of C. septicum from the gut [13].…”

Section: Discussionmentioning

confidence: 99%

Clostridium septicum myonecrosis complicating diarrhea-associated hemolytic uremic syndrome

et al. 2008

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We report the case of a 19-month-old male child with diarrhea-associated hemolytic uremic syndrome (HUS) who developed swelling of the right arm at the site of a peripherally inserted central venous catheter (PICC), fever, and later, ecchymosis. Wound cultures at the time of surgical debridement grew Clostridium septicum. The child subsequently required amputation of the right arm and prolonged therapy with parenteral penicillin and clindamycin. Clostridium septicum infections in children with HUS have been associated with a high rate of mortality. Along with colon cancer, diarrhea-associated HUS comprises a clinical entity which appears to predispose to atraumatic C. septicum infection, where acidic and anaerobic conditions in the diseased colon favor C. septicum invasion. Though not well recognized among pediatric nephrologists, C. septicum infection constitutes a severe, albeit rare, complication of diarrhea-associated HUS, but one in which a high index of suspicion is warranted as aggressive surgical and antibiotic therapy may be life-saving.

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“…In infants with C. septicum sepsis and meningitis, the predisposing condition was typically hemolytic uremic syndrome and hemorrhagic colitis secondary to E. coli O157: H7. 4,[6][7][8][9] Gastrointestinal tract colonization rates of neonates with clostridial species range from 7% to 70%. However, C. septicum is only grown from feces in 2-3% of healthy individuals.…”

confidence: 99%

“…3,4 C. septicum-related CNS complications have been reported in association with neutropenic enterocolitis and hemolytic uremic syndrome in children. [4][5][6][7][8][9] C. septicum bacteremia is associated with a high case-fatality rate, which is increased with CNS involvement. 4 We present a case of C. septicum brain abscesses in a neonate following suspected necrotizing enterocolitis, describe the patient's clinical course and management and review the literature regarding invasive C. septicum infections.…”

mentioning

confidence: 99%

Clostridium Septicum Brain Abscesses in a Premature Neonate

Sadarangani

Batdorf

Buchhalter

et al. 2014

Pediatric Infectious Disease Journal

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Brain Abscesses Caused by Clostridium Septicum as a Complication of Hemolyticuremic Syndrome

Cited by 18 publications

References 0 publications

A microbiological hazard of rural living:Clostridium septicumbrain abscess in a child withE coli0157 associated haemolytic uraemic syndrome: Figure 1

A microbiological hazard of rural living:Clostridium septicumbrain abscess in a child withE coli0157 associated haemolytic uraemic syndrome: Figure 1

Clostridium septicum myonecrosis complicating diarrhea-associated hemolytic uremic syndrome

Clostridium Septicum Brain Abscesses in a Premature Neonate

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