Brain actin demonstrated by immunofluorescence

Toh, Ban‐Hock; Cragg, B.G.; Singh, Surindar C.; Koh, Sharlynn

doi:10.1016/0014-4886(78)90098-5

Cited by 8 publications

(2 citation statements)

References 20 publications

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“…Phalloidin did not exhibit any differential expression across the ONLo and ONLi border established by the γ-catenin staining. The most intense staining for phalloidin was present in glomeruli, possibly reflecting the density of synapses in this neuropil (Toh et al, 1978;Kasowski et al, 1999;Rossler et al, 2002).…”

Section: Cytoskeletal Organization In the Onlmentioning

confidence: 92%

Cytoskeletal organization of the developing mouse olfactory nerve layer

Akins

Greer

2005

J of Comparative Neurology

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Olfactory sensory neuron (OSN) axonal extension and targeting occurs within the olfactory nerve layer (ONL) of the olfactory bulb (OB). The ONL can be differentiated into sublaminae: the outer (ONLo), where axons broadly target regions of the OB in tight fascicles, and inner (ONLi), where axons perform final targeting in loosely organized fascicles. During perinatal development cadherin-2 and its binding partner, gamma-catenin, are preferentially expressed by OSN axons in the ONLo versus the ONLi. Given the expression of these cytoskeletal associated molecules, we hypothesized that cytoskeletal elements of OSN axons may be differentially expressed across the ONL. We therefore examined cytoskeletal organization of OSN axons in the ONL, focusing on the day of birth (P0). We show that microfilaments, microtubules, and the intermediate filament (IF) vimentin are homogeneously expressed across the ONL at P0. In contrast, the IFs peripherin and alpha-internexin are preferentially localized to the ONLo at P0, with alpha-internexin expressed by a restricted subset of OSNs. We also show that OSN axons in the ONLo are significantly smaller than those in the ONLi. The data demonstrate that as OSN axons begin to exit the ONLo and target a specific region of the OB there is a down-regulation of cytoskeletal elements and bound extracellular adhesion molecules. The increase in axon diameter may reflect additional mechanisms involved in glomerular targeting or the formation of the large terminal boutons of OSN axons within glomeruli.

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Section: Cytoskeletal Organization In the Onlmentioning

confidence: 92%

Cytoskeletal organization of the developing mouse olfactory nerve layer

Akins

Greer

2005

J of Comparative Neurology

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“…ASMA are a heterogeneous group of autoantibodies which react with protein subunits of cytoplasmic filaments and therefore bind to a variety of cells in addition to smooth muscle, including platelets and vascular endothelium. 19, [24][25][26][27][28] The ASMA could therefore, have a primary role in symptom production through their ability to bind to vascular endothelium and/or platelets. Alternatively, or additionally, they could represent evidence of immune complex disease arising from a persistent antigenic stimulus as suggested by Vanast et al 10 for EB virus exposure in chronic benign daily headache.…”

Section: Discussionmentioning

confidence: 99%

Migraine Headaches, Migraine Equivalents and Anti‐Smooth Muscle Antibodies

Ludwig

Stiller²,

Burns³

et al. 1988

Headache

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SYNOPSIS We describe 20 patients with migraine headaches and/or migraine equivalents who had positive antinuclear antibodies (ANA) on routine laboratory screening: 17 of the 20 (85%) had elevated anti‐smooth muscle antibodies (ASMA) that were cytotoxic on Cr51 studies. No patient met criteria for defined autoimmune disorders and the remainder of an extensive autoantibody screen was unremarkable. Details of the clinical features and immunology of these patients are presented. The cytotoxicity of the ASMA suggests that they are capable of producing tissue damage and inflammation and could play a pathogenic role in the production of vascular headaches and/or central nervous system symptoms in these patients.

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