Brain activation during the perception of distorted body images in eating disorders

Brain structure alterations associated with weight changes in young females with anorexia nervosa: a case series

“…Reduced volume of the amygdala in patients with AN compared to controls has also been reported in previous studies (Friederich et al, 2012;Giordano et al, 2001). In addition, functional magnetic resonance imaging (fMRI) studies have repeatedly reported abnormal activation in this region in patients with AN (Ellison et al, 1998;Miyake et al, 2010Miyake et al, , 2012Seeger, Braus, Ruf, Goldberger, & Schmidt, 2002;Vocks et al, 2010;Vocks, Herpertz, Rosenberger, Senf, & Gizewski, 2011). Further, pallidum increase was associated with weight gain.…”

Body image distortions in bulimia nervosa: Investigating body size overestimation and body size satisfaction by fMRI

“…Miyake et al (2010) reported for bulimic patients in contrast to healthy controls and patients with anorexia nervosa less activation of the right amygdala and the left medial prefrontal cortex during the processing of the participants' own fat images. Different results were reported by Uher et al (2005), who found that activations to drawn body images in the posterior parietal and lateral occipitotemporal cortex were less strong in eating disorder patients (anorexia nervosa and bulimia nervosa) compared to control subjects, whereas activities in these areas were significantly higher for bulimic patients compared to patients with anorexia nervosa.…”

Metabolic Imaging of Deep Brain Stimulation in Anorexia Nervosa

“…The 2 studies showed that the activation of the amygdala may be involved in fearful emotional processing of negative words concerning body image 20 and their own fat image. 21 Moreover, the amygdala has connections to the hypothalamus and is also involved in food intake. 4 A food stimulus that is pleasurable when one is hungry may be unpleasant after satiation.…”