Brain age gap in neuromyelitis optica spectrum disorders and multiple sclerosis

Abstract

ObjectiveTo evaluate the clinical significance of deep learning-derived brain age prediction in neuromyelitis optica spectrum disorder (NMOSD) relative to relapsing-remitting multiple sclerosis (RRMS).MethodsThis cohort study used data retrospectively collected from 6 tertiary neurological centres in China between 2009 and 2018. In total, 199 patients with NMOSD and 200 patients with RRMS were studied alongside 269 healthy controls. Clinical follow-up was available in 85 patients with NMOSD and 124 patients with RRMS (mean duration NMOSD=5.8±1.9 (1.9–9.9) years, RRMS=5.2±1.7 (1.5–9.2) years). Deep learning was used to learn ‘brain age’ from MRI scans in the healthy controls and estimate the brain age gap (BAG) in patients.ResultsA significantly higher BAG was found in the NMOSD (5.4±8.2 years) and RRMS (13.0±14.7 years) groups compared with healthy controls. A higher baseline disability score and advanced brain volume loss were associated with increased BAG in both patient groups. A longer disease duration was associated with increased BAG in RRMS. BAG significantly predicted Expanded Disability Status Scale worsening in patients with NMOSD and RRMS.ConclusionsThere is a clear BAG in NMOSD, although smaller than in RRMS. The BAG is a clinically relevant MRI marker in NMOSD and RRMS.

In patients with mild disability NMOSD: is the alteration in the cortical morphological or functional network topological properties more significant

“…The increased node degree of left SMA side predicts the EDSS worsening, further indicating the presence of pseudoadaptive compensation of supplementary motor area, which is consistent with the hypothesis of the increase of node attributes discussed above. In a recent study of deep learning-derived brain age gap base on morphological MRI, the authors reported brain age gap (5.4 (95% CI 4.3 to 6.5) years) significantly predicted EDSS worsening in patients with NMOSD in the 6 tertiary neurological centers of China cohort ( 39 ). Future studies are required to determine the possible causative EDSS worsening factors in individual-scale parameters.…”