2013
DOI: 10.1186/1471-2318-13-98
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Brain aging and dementia during the transition from late adulthood to old age: design and methodology of the “Invece.Ab” population-based study

Abstract: BackgroundDeveloped countries are experiencing an unprecedented increase in life expectancy that is accompanied by a tremendous rise in the number of people with dementia. The purpose of this paper is to report on the study design and methodology of an Italian population-based study on brain aging and dementia in the elderly. This multi-domain study is structured in two phases. Our goal is to gather sufficient data to estimate the prevalence (phase I: cross-sectional study), the incidence and the progression o… Show more

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Cited by 49 publications
(69 citation statements)
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“…The participants were drawn from the 1321 responders in the cross-sectional phase of InveCe.Ab (Invecchiamento Cerebrale in Abbiategrasso, Brain Aging in Abbiategrasso ), an ongoing longitudinal population-based study of brain aging and dementia [14], which began on November 1, 2009 (ClinicalTrials.gov, NCT01345110). InveCe.Ab had a response rate of 80.4%, and no differences in age, birth area, or level of education were found between the responders and the nonresponders [15].…”
Section: Methodsmentioning
confidence: 99%
“…The participants were drawn from the 1321 responders in the cross-sectional phase of InveCe.Ab (Invecchiamento Cerebrale in Abbiategrasso, Brain Aging in Abbiategrasso ), an ongoing longitudinal population-based study of brain aging and dementia [14], which began on November 1, 2009 (ClinicalTrials.gov, NCT01345110). InveCe.Ab had a response rate of 80.4%, and no differences in age, birth area, or level of education were found between the responders and the nonresponders [15].…”
Section: Methodsmentioning
confidence: 99%
“…As already specified (Guaita et al, 2013), the InveCe.Ab study protocol was approved by the Ethics Committee of the University of Pavia. All the participants gave their written informed consent to the use of their personal data and agreed to provide a blood sample for biological analyses and DNA extraction.…”
Section: Methodsmentioning
confidence: 97%
“…The presence of cognitive impairment was established on the basis of neuropsychological and clinical examinations as described elsewhere (Guaita et al, 2013). Briefly, participants were administered nine tests covering five domains (memory, attention, language, executive and visuospatial function), the MMSE and the Clock Drawing Test.…”
Section: Endpoints and Diagnostic Criteriamentioning
confidence: 99%
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“…These subjects included 17 elderly subject (age range 77–79; 7 women and 10 men) and 8 young subjects (age range 25–34, 4 women and 4 men). All elderly subjects were community dwelling, functionally independent and participating to the InVeCe Ab population based study [26]. Healthy subjects were selected according to the guidelines of the Italian Health authorities and to the Declaration of Helsinki principles and signed an informed consent.…”
Section: Methodsmentioning
confidence: 99%