Brain atrophy and lesion load in a large population of patients with multiple sclerosis

Tedeschi, Gioacchino; Lavorgna, Luigi; Russo, Pierluigi; Prinster, Anna; Dinacci, Daria; Savettieri, Giovanni; Quattrone, Aldo; Livrea, Paolo; Messina, C; Reggio, A.; Morra, V. Brescia; Orefice, G; Paciello, M.; Brunetti, Arturo; Coniglio, Gabriella; Bonavita, Simona; Costanzo, Alfonso Di; Bellacosa, A.; Valentino, Paola; Quarantelli, Mario; Patti, Francesco; Salemi, Giuseppe; Cammarata, E.; Simone, I. L.; Salvatore, Marco; Bonavita, V.; Alfano, Bruno

doi:10.1212/01.wnl.0000168837.87351.1f

Cited by 145 publications

(146 citation statements)

References 23 publications

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“…Consequently, future research should directly identify possible links between underlying MS-related neuropathology, not only with facial affect recognition, but also with ToM. This seems particularly important given that, although white matter pathology is the primary neurological feature of MS, demyelination in cortical gray matter is also observed to a variable extent, and the focality of demyelinating lesions in MS can vary widely (Filley 2005 ;Tedeschi et al, 2005 ).…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

Evidence for deficits in facial affect recognition and theory of mind in multiple sclerosis

Henry

Phillips

Beatty³

et al. 2009

J Int Neuropsychol Soc

127

137

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Multiple sclerosis (MS) is a white matter disease associated with neurocognitive diffi culties. More recently the potential for white matter pathology to also disrupt important aspects of emotion understanding has been recognized. However, no study to date has assessed whether capacity for facial affect recognition and theory of mind (ToM) is disrupted in MS, or whether any observed defi cits are related to more general cognitive impairment. In the present study MS participants ( n = 27) and nonclinical controls ( n = 30) were administered measures of facial affect recognition, ToM, and cognitive functioning. MS participants were signifi cantly impaired on the ToM task, and also presented with specifi c defi cits decoding facial emotions of anger and fear. Performance on the measures of facial affect recognition and ToM were related to general cognitive functioning, and in particular, measures sensitive to executive dysfunction and information processing speed. These data highlight the need for future research to more fully delineate the extent and implications of emotion understanding diffi culties in this population. ( JINS , 2009, 15 , 277-285 .)

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Section: Limitations and Future Directionsmentioning

confidence: 99%

Evidence for deficits in facial affect recognition and theory of mind in multiple sclerosis

Henry

Phillips

Beatty³

et al. 2009

J Int Neuropsychol Soc

127

137

View full text Add to dashboard Cite

show abstract

“…Although being male has been proposed as a risk factor for cognitive impairment in MS patients [5], the results on brain neuropathological MS indices are conflicting, some studies have suggested a higher degree of brain damage in males [6][7][8], while others have failed to replicate these findings [9,10]. As these conflicting results might derive from gender interacting with other relevant demographic and clinical variables, we explored whether female and male MS patients, carefully matched for age, years of disease, level of education, intelligence quotient (IQ), neuropsychological performance and physical disability, differed in two indices of MS progression: gray matter (GM) atrophy and resting state functional connectivity (FC) changes.…”

Section: Introductionmentioning

confidence: 99%

Increased regional gray matter atrophy and enhanced functional connectivity in male multiple sclerosis patients

Sanchis‐Segura

Cruz-Gómez

Belenguer

et al. 2016

Neuroscience Letters

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“…Recently, the extension and pathological basis of GM pathology have been highlighted from pathological and neuroimaging studies [8]. GM atrophy, extensively reported in MS, begins early and evolves over the course of the disease, and GM tissue volumes are lower in MS patients than in control subjects [9][10][11][12][13][14][15]. The study of GM damage is of critical importance since axonal and neuronal damage are the main factors responsible for long-term disability in MS.…”

Section: Introductionmentioning

confidence: 99%

Fractal dimension analysis of grey matter in multiple sclerosis

Esteban

Sepulcre

Miras

et al. 2009

Journal of the Neurological Sciences

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The fractal dimension (FD) is a quantitative parameter that characterizes the morphometric variability of a complex object. Among other applications, FD has been used to identify abnormalities of the human brain in conventional magnetic resonance imaging (MRI), including white matter abnormalities in patients with Multiple Sclerosis (MS). Extensive grey matter (GM) pathology has been recently identified in MS and it appears to be a key factor in long-term disability. The aim of the present work was to assess whether FD measurement of GM in T1 MRI sequences can identify GM abnormalities in patients with MS in the early phase of the disease. A voxel-based morphometry approach optimized for MS was used to obtain the segmented brain, where we later calculated the three-dimensional FD of the GM in MS patients and healthy controls. We found that patients with MS had a significant increase in the FD of the GM compared to controls. Such differences were present even in patients with short disease durations, including patients with first attacks of MS. In addition, the FD of the GM correlated with T1 and T2 lesion load, but not with GM atrophy or disability. The FD abnormalities of the GM here detected differed from the previously published FD of the white matter in MS, suggesting that different pathological processes were taking place in each structure. These results indicate that GM morphology is abnormal in patients with MS and that this alteration appears early in the course of the disease.

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Brain atrophy and lesion load in a large population of patients with multiple sclerosis

Cited by 145 publications

References 23 publications

Evidence for deficits in facial affect recognition and theory of mind in multiple sclerosis

Evidence for deficits in facial affect recognition and theory of mind in multiple sclerosis

Increased regional gray matter atrophy and enhanced functional connectivity in male multiple sclerosis patients

Fractal dimension analysis of grey matter in multiple sclerosis

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