Brain barrier dysfunction in Cuban Epidemic Optic Neuropathy

Abstract

The possible association of increased permeability of the B-CSF B with oxidative stress, which lies on the basis of this epidemic outbreak, is discussed.

Interrelationships of undernutrition and neurotoxicity: Food for thought and research attention

“…Myelopathy lesions combined dorsal column deficits and pyramidal involvement of the lower limbs with spastic bladder (Román, 1994). Those with severe neurological impairment had increased permeability of the blood-cerebrospinal fluid regulatory interface, but this was not related to the severity of the visual deficits (González-Quevedo Monteagudo et al, 2008). …”

Reply to the Letter to the Editor ‘Cuban Epidemic Optic Neuropathy (CEON) and actual methods to measure immune response in central nervous system’

“…We appreciate Dr Dorta‐Contreras′ interest in our study and his insightful comments. As we pointed out in our original report [1], several hypotheses concerning the pathogenesis of CEON were suggested: toxic, nutritional, genetic and infectious. In general, the causes of tropical myeloneuropathic syndromes have been considered multifactorial, and this was also the case for CEON [2,3].…”

Cuban epidemic optic neuropathy (CEOP) and actual methods to measure immune response in CNS

“…I congratulate the authors of the paper about brain barrier dysfunction in Cuban epidemic optic neuropathy (CEOP) [1], the most devastating neurological outbreak in the world of the last century.…”