Interrelationships of undernutrition and neurotoxicity: Food for thought and research attention

Spencer, Peter S.; Palmer, Valerie S.

doi:10.1016/j.neuro.2012.02.015

Cited by 40 publications

(25 citation statements)

References 146 publications

(145 reference statements)

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“…Therefore, the more obese respondents who are exposed to toluene will have a higher health risk due to toluene exposure. The results of this study were similar to study which states that neurological diseases have a relationship with the condition of undernutrition or malnutrition which can cause nerve damage, especially in the peripheral nervous system (Spencer & Palmer, 2012).…”

Section: Correlation Between Characteristics Of Respondents With Neursupporting

confidence: 87%

Association Between Toluene Inhalation Exposure and Demography Towards Risk of Neurotoxic: A Cross-Sectional Study at Plastic Sack Industry Workers in Indonesia

Tualeka¹,

Wibrata²,

Ilmi³

et al. 2019

GJHS

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Toluene as a chemical often used by industry has effects that are harmful to the human body. One known effect was neurotoxic. Plastic industry workers are always exposed to toluene with a neurotoxic risk. Research on toluene exposure towards neurotoxic risk has never been done in Indonesia.The research subjects were printing workers in the PT X plastic sack industry. The design was cross-sectional with simple random sampling obtained 32 workers. Toluene concentration was measured using a gas chromatography device while the neurotoxic risk was measured using Q18 Questionnaire from German. The majority of the study subjects aged range of 36-45 years, worked more than 18 years, sometimes used personal protective equipment (PPE), and had nutritional status with criteria for overweight  (≥ 23.0 - 24.9). Demographic factors such as age, working period, personal protective equipment (PPE) and nutritional status have a significant relationship with neurotoxic risk. Indoor toluene concentration also had a significant relationship with neurotoxic risk. Continuous toluene exposure could cause apoptosis/damage to the myelin sheath in the nerves so that it can cause neurotoxin risks such as difficult to concentrate, emotional, dementia and sleep disturbances. Toluene exposure in plastic bag workers can cause a risk of neurotoxins such as difficult to concentrate, dementia,  and sleep disturbances. Plastic sack workers are required to use PPE regularly (especially masks) to reduce the risk of neurotoxins through toluene inhalation.

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Section: Correlation Between Characteristics Of Respondents With Neursupporting

confidence: 87%

Association Between Toluene Inhalation Exposure and Demography Towards Risk of Neurotoxic: A Cross-Sectional Study at Plastic Sack Industry Workers in Indonesia

Tualeka¹,

Wibrata²,

Ilmi³

et al. 2019

GJHS

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“…Whereas the blood-brain barrier to ivermectin is formed postnatally in rats, it is formed prenatally in humans, [123][124] although its functional integrity in states of human undernutrition is unclear. 125 The lack of evidence for recent ivermectin treatment in our investigation of Nodding Syndrome in Mundri County, South Sudan, coupled with the observation that head nodding was reported (1934) and medically observed (1960s) in Tanzania before the first clinical trials of ivermectin in Africa (1981), argue against ivermectin as a causal or risk factor for Nodding Syndrome.…”

Section: Parasitesmentioning

confidence: 87%

Nodding syndrome in Mundri county, South Sudan: Environmental, nutritional and infectious factors

Spencer¹,

Vandemaele

Richer³

et al. 2013

Afr H. Sci.

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Background: Nodding Syndrome is a seizure disorder of children in Mundri County, Western Equatoria, South Sudan. The disorder is reported to be spreading in South Sudan and northern Uganda. Results: Nodding Syndrome was associated with Onchocerca volvulus and Mansonella perstans infections, with food use of a variety of sorghum (serena) introduced as part of an emergency relief program, and was inversely associated with a history of measles infection. There was no evidence to suggest exposure to a manmade neurotoxic pollutant or chemical agent, other than chemically dressed seed intended for planting but used for food. Food use of cyanogenic plants was documented, and exposure to fungal contaminants could not be excluded. Conclusion: Nodding Syndrome in South Sudan has an unknown etiology. Further research is recommended on the association of Nodding Syndrome with onchocerciasis/mansonelliasis and neurotoxins in plant materials used for food.

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“…From conception to birth, the human egg, then the embryo and the fetus adapt, at a molecular and transcriptional level, to various changes in their cellular environment . Folate and vitamin B12 deficiencies in the periconceptional period contribute to neural tube defects, and low serum levels of B12 have been linked to negative cognitive, motor and growth outcomes, which commonly involve the central and peripheral nervous system . Although the pathogenesis of NTDs is certainly multifactorial, malnutrition after bariatric surgery has to be considered a major risk factor: maternal diet is the source of all the essential elements that are the basic components of transcriptional factors, growth factors and messengers needed for embryological and fetal cell signalling and development.…”

Section: Characteristics Of the Patientsmentioning

confidence: 99%

Fetal neural tube defects in pregnant women previously submitted to bariatric surgery: more attention to a new emerging entity

et al. 2012

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Interrelationships of undernutrition and neurotoxicity: Food for thought and research attention

Cited by 40 publications

References 146 publications

Association Between Toluene Inhalation Exposure and Demography Towards Risk of Neurotoxic: A Cross-Sectional Study at Plastic Sack Industry Workers in Indonesia

Association Between Toluene Inhalation Exposure and Demography Towards Risk of Neurotoxic: A Cross-Sectional Study at Plastic Sack Industry Workers in Indonesia

Nodding syndrome in Mundri county, South Sudan: Environmental, nutritional and infectious factors

Fetal neural tube defects in pregnant women previously submitted to bariatric surgery: more attention to a new emerging entity

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