Brain dendritic cells: biology and pathology

D’Agostino, Paul M.; Gottfried-Blackmore, Andrés; Anandasabapathy, Niroshana; Bulloch, Karen

doi:10.1007/s00401-012-1018-0

Cited by 158 publications

(140 citation statements)

References 164 publications

(197 reference statements)

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“…Aside from the splenic hemophagocytic variant, HS in dogs is believed to arise primarily from interstitial dendritic cells 1. Within the CNS, these cells are considered to be restricted to the meninges and choroid plexus 19. Our data are consistent with these views as tumors in all dogs were observed to have some contact with the meninges on histologic examination, even those that appeared to be in an intramedullary location based on diagnostic imaging studies.…”

Section: Discussionsupporting

confidence: 84%

Histiocytic Sarcoma with Central Nervous System Involvement in Dogs: 19 Cases (2006–2012)

Mariani

Jennings

Olby

et al. 2015

Veterinary Internal Medicne

100

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BackgroundReports of histiocytic sarcoma (HS) involving the central nervous system (CNS) are sparse and consist mainly of case reports describing 1–3 animals.ObjectiveThe objective of this study was to report the signalments, clinical signs, clinicopathologic and diagnostic imaging findings, treatment, and outcome of a series of dogs with HS and CNS involvement.AnimalsNineteen dogs with HS examined at veterinary referral hospitals.MethodsRetrospective case series. Medical records were reviewed and cases with a histopathological diagnosis of CNS HS were included in the study. Diagnostic imaging studies of the CNS were evaluated and histopathologic samples were reviewed to confirm the diagnosis.ResultsRetrievers and Pembroke Welsh Corgis were overrepresented in this cohort of dogs. Tumors involved the brain in 14 dogs and the spinal cord in 5. In 4 dogs, HS was part of a disseminated, multiorgan process whereas it appeared confined to the CNS in 15 dogs. Diagnostic imaging had variable appearances although extraaxial masses predominated in the brain. There was meningeal enhancement in all dogs that was often profound and remote from the primary mass lesion. Pleocytosis was present in all dogs with CSF evaluation. Median survival was 3 days.Conclusions and Clinical ImportanceBreed predispositions appear to vary from reports of HS in other organ systems. Some unique imaging and clinicopathologic characteristics, particularly brain herniation, profound meningeal enhancement, and pleocytosis in combination with 1 or more mass lesions, might help to differentiate this neoplasm from others involving the CNS, although this requires further study.

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Section: Discussionsupporting

confidence: 84%

Histiocytic Sarcoma with Central Nervous System Involvement in Dogs: 19 Cases (2006–2012)

Mariani

Jennings

Olby

et al. 2015

Veterinary Internal Medicne

100

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“…Indirect evidences also indicate that DC constitute another subgroup of candidate APC to migrate from the brain to lymph nodes (35,36); CCR7-mediated chemotaxis of DC facilitates lymph node entry through the high endothelial venules, promoted by a CCL21 chemokine gradient (22).…”

Section: Cns Resident Immune Cellsmentioning

confidence: 98%

Tumor infiltrating immune cells in gliomas and meningiomas

Domingues

González-Tablas

Otero

et al. 2016

Brain, Behavior, and Immunity

252

244

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“…43,87 Also, dendritic cells are located in the meninges and choroid plexi but not in the brain. 19 Hence, the apparent site of initiation of CNS HS does have a resident population of interstitial DCs from which HS could develop.…”

Section: Distinctive Histiocytic Sarcoma Syndromesmentioning

confidence: 99%

A Review of Histiocytic Diseases of Dogs and Cats

2014

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Histiocytic proliferative disorders are commonly observed in dogs and less often cats. Histiocytic disorders occur in most of the dendritic cell (DC) lineages. Canine cutaneous histiocytoma originates from Langerhans cells (LCs) indicated by expression of CD1a, CD11c/CD18, and E-cadherin. When histiocytomas occur as multiple lesions in skin with optional metastasis to lymph nodes and internal organs, the disease resembles cutaneous Langerhans cell histiocytosis of humans. Langerhans cell disorders do not occur in feline skin. Feline pulmonary LCH has been recognized as a cause of respiratory failure due to diffuse pulmonary infiltration by histiocytes, which express CD18 and E-cadherin and contain Birbeck's granules. In dogs and cats, histiocytic sarcomas (HS) arise from interstitial DCs that occur in most tissues of the body. Histiocytic sarcomas begin as localized lesions, which rapidly disseminate to many organs. Primary sites include spleen, lung, skin, brain (meninges), lymph node, bone marrow, and synovial tissues of limbs. An indolent form of localized HS, progressive histiocytosis, originates in the skin of cats. Hemophagocytic HS originates in splenic red pulp and bone marrow macrophages in dogs and cats. In dogs, histiocytes in hemophagocytic HS express CD11d/CD18, which is a leuko-integrin highly expressed by macrophages in splenic red pulp and bone marrow. Canine reactive histiocytic diseases, systemic histiocytosis (SH) and cutaneous histiocytosis, are complex inflammatory diseases with underlying immune dysregulation. The lesions are dominated by activated interstitial DCs and lymphocytes, which invade vessel walls and extend as vasocentric infiltrates in skin, lymph nodes, and internal organs (SH).

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Brain dendritic cells: biology and pathology

Cited by 158 publications

References 164 publications

Histiocytic Sarcoma with Central Nervous System Involvement in Dogs: 19 Cases (2006–2012)

Histiocytic Sarcoma with Central Nervous System Involvement in Dogs: 19 Cases (2006–2012)

Tumor infiltrating immune cells in gliomas and meningiomas

A Review of Histiocytic Diseases of Dogs and Cats

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