Tumor infiltrating immune cells in gliomas and meningiomas

Domingues, Patrícia H.; González-Tablas, María; Otero, Álvaro; Pascual, Daniel; Miranda, David A.; Ruíz, Laura; Sousa, Pablo; Ciudad, Juana; Gonçalves, Jesús María; Lopes, María Celeste; Órfão, Alberto; Tabernero, María Dolores

doi:10.1016/j.bbi.2015.07.019

Cited by 252 publications

(256 citation statements)

References 133 publications

(175 reference statements)

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“…These immune cells typically include natural killer (NK) cells, T lymphocytes, macrophages, dendritic cells (DC), myeloid-derived suppressor cells (MDSCs), and B cells (7). These cells serve different functions and combine or cancel out each other, thus creating the microenvironment for lung cancer.…”

Section: Introductionmentioning

confidence: 99%

The paradoxical role of tumor-infiltrating immune cells in lung cancer

Zheng

Yao

2017

IRDR

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Section: Introductionmentioning

confidence: 99%

The paradoxical role of tumor-infiltrating immune cells in lung cancer

Zheng

Yao

2017

IRDR

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“…In contrast, when MWCNTs were administrated within tumoral tissue, we observed diffusion of the MWCNTs that could be explained by the increased capacity of tumor cells to endocytose either the CNTs or the macrophages and immune cells infiltrating the tumor (Figure 14). 52,63 To know whether the MWCNTs were able to induce cell death and increase the survival of rats implanted with intracerebral GBM, four types of MWCNTs were intratumorally injected. The results showed a significant increase in survival in animals treated with N-MWCNTs-ox (38 vs 27 days, P=0.015) compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity induced by carbon nanotubes in experimental malignant glioma

Romano-Feinholz¹,

Salazar-Ramiro

Muñoz‐Sandoval³

et al. 2017

IJN

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Despite multiple advances in the diagnosis of brain tumors, there is no effective treatment for glioblastoma. Multiwalled carbon nanotubes (MWCNTs), which were previously used as a diagnostic and drug delivery tool, have now been explored as a possible therapy against neoplasms. However, although the toxicity profile of nanotubes is dependent on the physicochemical characteristics of specific particles, there are no studies exploring how the effectivity of the carbon nanotubes (CNTs) is affected by different methods of production. In this study, we characterize the structure and biocompatibility of four different types of MWCNTs in rat astrocytes and in RG2 glioma cells as well as the induction of cell lysis and possible additive effect of the combination of MWCNTs with temozolomide. We used undoped MWCNTs (labeled simply as MWCNTs) and nitrogen-doped MWCNTs (labeled as N-MWCNTs). The average diameter of both pristine MWCNTs and pristine N-MWCNTs was ~22 and ~35 nm, respectively. In vitro and in vivo results suggested that these CNTs can be used as adjuvant therapy along with the standard treatment to increase the survival of rats implanted with malignant glioma.

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“…1B). Higher grade brain tumors lead to exacerbated irregular vascularization, BBB disruption, tumor necrosis, and antigen expulsion [27–30] (Fig. 1A).…”

Section: Neuro-onco-immunologymentioning

confidence: 99%

“…However, T-cell function overall is paralyzed by common cytokines expressed in the tumor microenvironment (e.g., VEGF, TGFβ, IL10, PGE2, etc.) [30,32,41]. Impaired T-cells have lower proliferation and an overall attenuated response to pro-inflammatory signals, leading to overall down-regulation of major histocompatibility complexes (MHCs) and DC maturation [32,49].…”

Section: Neuro-onco-immunologymentioning

confidence: 99%

Engineering challenges for brain tumor immunotherapy

Lyon

Mokarram

Saxena

et al. 2017

Advanced Drug Delivery Reviews

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Malignant brain tumors represent one of the most devastating forms of cancer with abject survival rates that have not changed in the past 60 years. This is partly because the brain is a critical organ, and poses unique anatomical, physiological, and immunological barriers. The unique interplay of these barriers also provides an opportunity for creative engineering solutions. Cancer immunotherapy, a means of harnessing the host immune system for anti-tumor efficacy, is becoming a standard approach for treating many cancers. However, its use in brain tumors is not widespread. This review discusses the current approaches, and hurdles to these approaches in treating brain tumors, with a focus on immunotherapies. We identify critical barriers to immunoengineering brain tumor therapies and discuss possible solutions to these challenges.

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Tumor infiltrating immune cells in gliomas and meningiomas

Cited by 252 publications

References 133 publications

The paradoxical role of tumor-infiltrating immune cells in lung cancer

The paradoxical role of tumor-infiltrating immune cells in lung cancer

Cytotoxicity induced by carbon nanotubes in experimental malignant glioma

Engineering challenges for brain tumor immunotherapy

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