Brain-Derived Neurotrophic Factor as a Biomarker in Primary Open-Angle Glaucoma

Ghaffariyeh, Alireza; Honarpisheh, Nazafarin; Heidari, Mohammad Hossein; Puyan, Sadollah; Abasov, Fuad

doi:10.1097/opx.0b013e3181fc329f

Cited by 59 publications

(45 citation statements)

References 41 publications

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“…[26][27][28] In the only study investigating serum BDNF levels in AMD, serum BDNF levels were found to be significantly higher in AMD patients compared to controls. 29 The authors concluded that BDNF release from the CNS may be increased in response to degenerative process in the retina and confounding factors such as stress and exercise might affect their outcome.…”

Section: Discussionmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor in Patients With Age-Related Macular Degeneration and Its Correlation With Retinal Layer Thicknesses

Tekin

Şekeroğlu

Demirtaş

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To determine brain-derived neurotrophic factor (BDNF) levels in serum and aqueous humor (AH) and to assess the relationship between BDNF levels and retinal layer thicknesses in age-related macular degeneration (AMD). METHODS.A total of 48 AMD patients (AMD group) that was composed of twenty-three nonexudative and 25 exudative patients and 26 control subjects (control group) were included in the study. Serum and AH BDNF levels were assessed by ELISA method. Retinal layer thicknesses were calculated by segmentation analysis of optical coherence tomography. RESULTS.The mean BDNF levels in AH were found to be significantly lower in both the nonexudative and exudative AMD groups than in the control group (P ¼ 0.003 and P < 0.001, respectively). Optical coherence tomography segmentation analysis revealed that the total average retina pigment epithelium thickness was statistically significantly thinner in the nonexudative AMD group compared with the exudative AMD and control groups (P ¼ 0.001 and P ¼ 0.040, respectively). The total average outer nuclear layer (ONL) thicknesses of nonexudative and exudative AMD cases were reduced compared to control group; however, the decrement was statistically significant only in the nonexudative AMD group (P ¼ 0.009). In the correlation analysis of BDNF levels with retinal layer thicknesses, statistically significant correlations exist between BDNF levels of AH with ONL thicknesses in cases of AMD and with retina pigment epithelium thicknesses in the nonexudative AMD group.CONCLUSIONS. BDNF concentrations in AH decreased in the AMD group and this decrease correlates with outer retinal layer thicknesses. Low BDNF levels detected in the AMD group may be insufficient to protect the photoreceptors, resulting in thinning of ONL.

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Section: Discussionmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor in Patients With Age-Related Macular Degeneration and Its Correlation With Retinal Layer Thicknesses

Tekin

Şekeroğlu

Demirtaş

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…BDNF is transported to the retinal ganglion cell bodies through a retrograde axonal transportation system and the synaptic connections within (45) . BDNF in the tears of normal tension glaucoma patients is signifi cantly less than normal, and this may be a potential diagnostic biomarker for early detection of normal tension glaucoma.…”

Section: Bdnfmentioning

confidence: 99%

“…BDNF crosses the blood-brain barrier and as a result, the level of this factor in the blood can relatively refl ect its concentration in the brain. BDNF levels in serum were determined in POAG patients and controls by ELISA (45) . The authors concluded that BDNF in the serum might be a useful biochemical marker for early detection of POAG.…”

Section: Bdnfmentioning

confidence: 99%

Biomarkers in primary open angle glaucoma

Kokotas

Kroupis

Chiras

et al. 2012

Clinical Chemistry and Laboratory Medicine (CCLM)

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Glaucoma, a leading cause of blindness worldwide, is currently defi ned as a disturbance of the structural or functional integrity of the optic nerve that causes characteristic atrophic changes in the optic nerve, which may lead to specifi c visual fi eld defects over time. This disturbance usually can be arrested or diminished by adequate lowering of intraocular pressure (IOP). Glaucoma can be divided roughly into two main categories, ' open angle ' and ' closed angle ' glaucoma. Open angle, chronic glaucoma tends to progress at a slower rate and patients may not notice loss of vision until the disease has progressed signifi cantly. Primary open angle glaucoma (POAG) is described distinctly as a multifactorial optic neuropathy that is chronic and progressive with a characteristic acquired loss of optic nerve fi bers. Such loss develops in the presence of open anterior chamber angles, characteristic visual fi eld abnormalities, and IOP that is too high for the healthy eye. It manifests by cupping and atrophy of the optic disc, in the absence of other known causes of glaucomatous disease. Several biological markers have been implicated with the disease. The purpose of this study was to summarize the current knowledge regarding the non-genetic molecular markers which have been predicted to have an association with POAG but have not yet been validated.

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“…BDNF has been found significantly decreased in the tears of normal tension glaucoma patients and open angle glaucoma patients in comparison to controls (Ghaffariyeh et al, 2011).…”

Section: Molecular Biomarkers In Glaucomamentioning

confidence: 98%