Brain-derived neurotrophic factor correlated with muscle strength in subjects undergoing stationary bicycle exercise training

Relationship between body weight and the increment in serum brain-derived neurotrophic factor after oral glucose challenge in men with obesity and metabolic syndrome

“…[ 33 53 54 ] Second, all subjects with obesity underwent both diet restriction and exercise promotion. We previously reported that an increase in muscle power after aerobic exercise promotion, independent of body-weight change, could increase fasting serum BDNF [37] . However, in the current study we could not determine which type of life-style change provided the greater effect in reducing the BDNF AUC index.…”

“…However, fasting BDNF concentration was not significantly associated with body-fat mass, and did not significantly correlate with body-weight change in our previous studies. [ 32 37 ] As BDNF concentration responded to the stimulation of food intake, our findings together suggested that the postprandial elevation of circulating BDNF, but not the fasting level, might be responsible for obesity in men.…”

The influence of aging on the methylation status of brain‐derived neurotrophic factor gene in blood

“…A wide body of evidences indicates the exposure to stressful events in adulthood changes DNAm in rodent brains. Several clinical studies have suggested the possibility that stressful events can alter DNAm of the BDNF gene in blood or brain . For example, we previously reported that DMRs in 28 of 35 CpG units at CpG I of the BDNF gene in blood were changed in unmedicated patients with major depression as compared with healthy subjects .…”

“…In fact, there was no correlation between DMRs and serum BDNF levels in this study. In addition, although Pan and colleagues showed the transport of BDNF across the blood‐brain barrier, it is known that plasma BDNF is, at least in part, derived from the muscle . In this context, plasma BDNF is derived from both the brain and muscle.…”

Fueling Up Skeletal Muscle to Reduce Obesity: A TrkB Story

“…BNDF administration is known to increase insulin production in pancreatic beta cells, improve insulin sensitivity in skeletal muscle, decrease glucose production in hepatocytes, and enhance glucose uptake in muscle and liver (Marosi and Mattson, 2014). Moreover, local production of BDNF can be induced by exercise stimulation in skeletal muscle, indicating a role of BDNF in neuro-muscluar axis (Tsai et al, 2015). Furthermore, BDNF stimulates activation of AMPK, which is a key sensor for energy metabolism and exercise endurance in skeletal muscle (Matthews et al, 2009).…”